Libby Lab

Richard T. Libby, PhD

  • Assistant Professor - Department of Ophthalmology (SMD) - Primary Appointment
  • Assistant Professor - Department of Biomedical Genetics (SMD)
  • Doctorate in Biology | Boston College (1997)
  • Postdoctoral Fellow (Attended 2001 - 2005)
  • Postdoctoral Scientist (Attended 1998 - 2001)

Research Overview

Glaucoma is a complex group of diseases where many different genetic and environmental factors conspire to cause vision loss. While there are many different causes of glaucoma, the ultimate cause of vision loss in all glaucomas is the death of retinal ganglion cells (RGCs), the output neurons of the retina. Therefore, glaucoma is a neurodegeneration. Our lab focuses on the neurobiology of glaucoma. Primarily, we use mouse models of glaucoma and advanced mouse genetics to probe the pathophysiology of glaucoma.

Specifically, we are interested in understanding the molecular processes that lead to RGC death in glaucoma and why are RGCs more likely to die in some patients than in others.

Recent Publications

Showing 5 of 51 journal articles.

Strazzeri JM; Hunter JJ; Masella BD; Yin L; Fischer WS; Diloreto DA; Libby RT; Williams DR; Merigan WH. "Focal damage to macaque photoreceptors produces persistent visual loss." Experimental eye research.. 2014; 119():88-96. Epub 2013 Dec 05.

Coleman JA; Zhu X; Djajadi HR; Molday LL; Smith RS; Libby RT; John SW; Molday RS. "Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival." Journal of cell science.. 2014; 127(Pt 5):1138-49. Epub 2014 Jan 10.

Harder JM; Libby RT. "Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death." Cell death and differentiation. 2013; 20(1):182. Epub 2012 Sep 21.

Zhou Y; Tanzie C; Yan Z; Chen S; Duncan M; Gaudenz K; Li H; Seidel C; Lewis B; Moran A; Libby RT; Kiernan AE; Xie T. "Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye." Proceedings of the National Academy of Sciences of the United States of America.. 2013; 110(22):8966-71. Epub 2013 May 15.

Howell GR; Libby RT. "Adding metabolomics to the toolbox for studying retinal disease." Investigative ophthalmology & visual science.. 2013; 54(6):4260. Epub 2013 Jun 21.

More articles...

Contact

Richard T. Libby, PhD
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 659
Rochester, NY 14642