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Libby Lab

Richard T. Libby, PhD

• Assistant Professor - Department of Ophthalmology (SMD) - Primary Appointment
• Assistant Professor - Department of Biomedical Genetics (SMD)
• Doctorate in Biology | Boston College (1997)
• Postdoctoral Fellow (Attended 2001 - 2005)
• Postdoctoral Scientist (Attended 1998 - 2001)

Research Bio

Glaucoma is a complex group of diseases where many different genetic and environmental factors conspire to cause vision loss. While there are many different causes of glaucoma, the ultimate cause of vision loss in all glaucomas is the death of retinal ganglion cells (RGCs), the output neurons of the retina. Therefore, glaucoma is a neurodegeneration. Our lab focuses on the neurobiology of glaucoma. Primarily, we use mouse models of glaucoma and advanced mouse genetics to probe the pathophysiology of glaucoma.

Specifically, we are interested in understanding the molecular processes that lead to RGC death in glaucoma and why are RGCs more likely to die in some patients than in others.

Recent Publications

Showing 5 of 41 journal articles.

Howell GR; Soto I; Libby RT; John SW. "Intrinsic axonal degeneration pathways are critical for glaucomatous damage." Experimental neurology. 2012; Epub 2012 Jan 18.

Geng Y; Dubra A; Yin L; Merigan WH; Sharma R; Libby RT; Williams DR. "Adaptive optics retinal imaging in the living mouse eye." Biomedical optics express. 2012; 3(4):715-34. Epub 2012 Mar 15.

Howell GR; Soto I; Zhu X; Ryan M; Macalinao DG; Sousa GL; Caddle LB; Macnicoll KH; Barbay JM; Porciatti V; Anderson MG; Smith RS; Clark AF; Libby RT; John SW. "Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma." The Journal of clinical investigation. 2012; 122(4):1246-61. Epub 2012 Mar 19.

Fernandes KA; Harder JM; Fornarola LB; Freeman RS; Clark AF; Pang IH; John SW; Libby RT. "JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death." Neurobiology of disease. 2012; 46(2):393-401. Epub 2012 Feb 14.

Geng Y; Schery LA; Sharma R; Dubra A; Ahmad K; Libby RT; Williams DR. "Optical properties of the mouse eye." Biomedical optics express. 2011; 2(4):717-38. Epub 2011 Feb 28.

More articles...

Contact

Richard T. Libby, PhD
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 659
Rochester, NY 14642