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Libby Lab

Richard T. Libby, PhD

• Assistant Professor - Department of Ophthalmology (SMD) - Primary Appointment
• Assistant Professor - Department of Biomedical Genetics (SMD)
• Doctorate in Biology | Boston College (1997)
• Postdoctoral Fellow (Attended 2001 - 2005)
• Postdoctoral Scientist (Attended 1998 - 2001)

Research Bio

Glaucoma is a complex group of diseases where many different genetic and environmental factors conspire to cause vision loss. While there are many different causes of glaucoma, the ultimate cause of vision loss in all glaucomas is the death of retinal ganglion cells (RGCs), the output neurons of the retina. Therefore, glaucoma is a neurodegeneration. Our lab focuses on the neurobiology of glaucoma. Primarily, we use mouse models of glaucoma and advanced mouse genetics to probe the pathophysiology of glaucoma.

Specifically, we are interested in understanding the molecular processes that lead to RGC death in glaucoma and why are RGCs more likely to die in some patients than in others.

Recent Publications

Showing 5 of 47 journal articles.

Harder JM; Libby RT. "Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death." Cell death and differentiation. 2013; 20(1):182. Epub 2012 Sep 21.

Fernandes KA; Harder JM; Kim J; Libby RT. "JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells." Experimental eye research. 2013; Epub 2013 May 03.

Jiang Y; Ding Q; Xie X; Libby R; Lefebvre V; Gan L. "Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells." The Journal of biological chemistry. 2013; Epub 2013 May 06.

Harder JM; Fernandes KA; Libby RT. "The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice." 2012; 2():530. Epub 2012 Jul 25.

Zhu X; Libby RT; de Vries WN; Smith RS; Wright DL; Bronson RT; Seburn KL; John SW. "Mutations in a P-type ATPase gene cause axonal degeneration." PLoS genetics. 2012; 8(8):e1002853. Epub 2012 Aug 09.

More articles...

Contact

Richard T. Libby, PhD
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 659
Rochester, NY 14642