Merigan Lab William Merigan, PhD View Merigan profile Professor - Department of Ophthalmology (SMD) - Primary Appointment Professor - Center for Visual Science (RC) PhD | Psychology, All Other | Univ of Maryland (1975) Research Overview Dr. Merigan's research examines the role of retinal ganglion cells in visual perception in the primate (human and macaque). The primate retina contains at least 14 different types of retinal ganglion cells, and each type forms a complete network across the retina. Because the size, shape andprojections of each of the cell types is distinctive, it is thought that they may play quite different and possibly independent roles invisual function,but at present relatively little is known about this question. Some clues about possible functions of different ganglion cell classes comes from their structure (some extend across large swaths of retina, while others get input from tiny regions of retina), their physiology (some ganglion cells respond to color, while others are color blind), and their projections into the brain (some ganglion cells project to visual cortex while others reach the superchiasmatic nucleus, which is thought to be important in diurnal rhythms). Selected Publications Sharma R, Yin L, Geng Y, Merigan W, Palczewska G, Palczewski K, Williams D, Hunter J (2013), In vivo two-photon imaging of the mouse retina. Biomed. Opt. Express 4, 1285-1293. Rossi, E.A., Chung, M., Dubra, A., Hunter, J.J., Merigan, W.H., Williams, D.R. (2011). Imaging retinal mosaics in the living eye. Eye 25:301-308; doi:10.1038/eye.2010.221. Morgan, J.I.W., Hunter, J.J., Williams, D.R., Merigan, W.H. (2009). The reduction of retinal autofluorescence caused by light exposure. Invest Ophthalmol Vis Sci., 50(12):6015-22. Morgan, J.I.W., Dubra, A., Wolfe, R., Merigan, W.H., Williams, D.R. (2009). In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic. IOVS, 50(3), 1350-1359. Scoles, D., Gray, D.C., Hunter, J.J., Wolfe, R., Gee, B.P., Geng, Y., Masella, B.D., Libby, R.T., Russell, S., Williams, D.R., Merigan, W.H. (2009). In vivo imaging of retinal nerve fiber layer vasculature: imaging - histology comparison. BMC Ophthalmology, 9:9 doi:10.1186/1471-2415-9-9. Morgan, J.I.W., Hunter, J.J., Masella, B., Wolfe, R., Gray, D.C., Merigan, W.H., Delori, F.C., Williams, D.R. (2008). Light-Induced Retinal Changes Observed with High-Resolution Autofluorescence Imaging of the Retinal Pigment Epithelium. IOVS, 49(8), 3715-3729.