UR Faculty: Carl D'Angio

M.D. (1983) Johns Hopkins	Carl D'Angio Assistant Professor of Pediatrics (Neonatology) Primary Appointment: Department of Pediatrics GEBS Cluster Affiliations: IMV - Immunology, Microbiology, and Virology
Research: Chemokines and Lung Injury
Contact Information: E-Mail: carl_dangio@urmc.rochester.edu
University of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 651 Rochester, New York 14642	Medical Center 4-3266 Phone: (585) 273-4911 Fax: (585) [number]

Research Overview

Our laboratory is interested in the role of a class of messengers known as chemokines in the development and resolution of inflammation following lung injury. We are focusing on two main causes of injury:

Oxygen-induced lung injury
Infection-related lung injury

We are using crucial differences between the two injuries to understand the mechanisms that underlie inflammation. Experiences available in the laboratory include work with animals, isolated cells, cell lines, human specimens and a variety of molecular biological techniques.

Recent Publications

D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am J Physiol Lung Cell Mol Physiol. 286:L30-6, 2004.

Varughese R, Nayak JL, LoMonaco M, O'Reilly MA, Ryan RM, D'Angio CT. Effects of hyperoxia on tumor necrosis factor alpha and Grobeta expression in newborn rabbit lungs. Lung. 181:335-46, 2003.

Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT. Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release. Inflammation. 27:137-45, 2003.

D'Angio CT, Sinkin RA, Stevens TP, Landfish NK, Merzbach JL, Ryan RM, Phelps DL, Palumbo DR, Myers GJ. Longitudinal, 15-year follow-up of children born at less than 29 weeks' gestation after introduction of surfactant therapy into a region: neurologic, cognitive, and educational outcomes. Pediatrics 110:1094-102, 2002.

D'Angio CT, Basavegowda K, Avissar NE, Finkelstein JN, Sinkin RA. Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants. Biol Neonate 82:145-9, 2002.

Butler-O'Hara M, D'Angio CT. Risk of persistent renal insufficiency in premature infants following the prenatal use of indomethacin for suppression of preterm labor. J Perinatol. 22:541-6, 2002.

Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am J Pathol. 161:1383-93, 2002.

Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, Ryan RM. Transforming growth factor alpha (TGF(alpha)) is increased during hyperoxia and fibrosis. Exp Lung Res. 28:361-72, 2002.

D'Angio CT, Maniscalco WM. The role of vascular growth factors in hyperoxia-induced injury to the developing lung. Front Biosci. 7:d1609-23, 2002.

Hastings RH, Ryan RM, D'Angio CT, Holm BA, Patel A, Quintana R, Biederman E, Burton DW, Deftos LJ. Parathyroid hormone-related protein response to hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 282:L1198-208, 2002.

D'Angio CT, Ambati J, Phelps DL. Do urinary levels of vascular endothelial growth factor predict proliferative retinopathy? Curr Eye Res. 22:90-4, 2001.

O'Reilly MA, Staversky RJ, Huyck HL, Watkins RH, LoMonaco MB, D'Angio CT, Baggs RB, Maniscalco WM, Pryhuber GS. Bcl-2 family gene expression during severe hyperoxia induced lung injury. Lab Invest 80:1845-54, 2000.

D'Angio CT, Finkelstein JN. Oxygen regulation of gene expression: A study in opposites. Mol Genet Metab. 71:371-80, 2000.

PubMed Publication List

PubMed is maintained by the National Library of Medicine
and provides complete abstracts of all 'd'angio c' publications,
as well as links to the full text of many articles (at journal homepages).

Back to Department of Pediatrics

GEBS Clusters:

IMV