UR Faculty: Edward M. Schwarz

Ph.D. (1993) Albert Einstein College of Medicine	Edward M. Schwarz Professor of Orthopaedics and of Microbiology & Immunology Primary Appointment: Orthopaedics GEBS Cluster Affiliations: IMV - Immunology, Microbiology, and Virology PWD - Pathways of Human Disease GGD Genetics, Genomics and Development
Research: Pro-inflammatory cytokine signal transduction and novel drug and gene therapies for Rheumatoid Arthritis.
Contact Information: E-Mail: Edward_Schwarz@urmc.rochester.edu
University of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 665 Rochester, New York 14642	Medical Center 1-8533 Phone: (585) 275-3063 Fax: (585) 756-4721

Research Overview

My laboratory is primarily interested in NFkB signal transduction and how this pathway regulates cellular response in innate and acquired immunity. By generating transgenic and knockout mice, we have developed animal models of rheumatoid arthritis, periprothetic aseptic loosening, and immunodeficiency. We are actively working to elucidate the molecular etiology in these mice, and design rational drug and gene therapy strategies to cure the disease in these animals. Successful approaches will be directly translated to determine efficacy in patients that suffer from these conditions.

Recent Publications

Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.
Nat Med. Mar;11(3):291-7, 2005. Epub 2005 Feb 13.

Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther. Aug;12(2):212-8, 2005.

Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM.
Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. Jun;113(6):749-55, 2005.

Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. 34:809-17, 2004.

Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. J Cell Biochem. 92:316-31, 2004.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res. 19:207-13, 2004.

Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol. 198:428-40, 2004.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum. 50:265-76, 2004.

Wooley PH, Schwarz EM. Aseptic loosening. Gene Ther. 11:402-7, 2004. Review.

Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells. Gene Ther. 11:34-41, 2004.

Zuscik MJ, Rosier RN, Schwarz EM. Altered negative regulation of transforming growth factor beta signaling in scleroderma: Potential involvement of SMURF2 in disease. Arthritis Rheum 48:1779-1780, 2003.

Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM. Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing. J Orthop Res 21:676-84, 2003.

Huang W, O'Keefe RJ, Schwarz EM. Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation. Arthritis Res Ther 5:R49-59, 2003.

Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM. Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest. 111:821-31, 2003.

Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem. 278:438-43, 2003.

Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles. J Orthop Res. 20:714-22, 2002.

Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 109:1405-15, 2002.

Yin G, Liu W, An P, Li P, Ding I, Planelles V, Schwarz EM, Min W. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol Ther. 5:547-54, 2002.

PubMed Publication List

PubMed is maintained by the National Library of Medicine
and provides complete abstracts of all 'schwarz e' publications,
as well as links to the full text of many articles (at journal homepages).

Back to Orthopaedics

GGD

IMV

PWD