UR Faculty: David A. Bushinsky

M.D. (1975) Tufts University School of Medicine	David A. Bushinsky Professor of Medicine, Nephrology Unit and of Pharmacology and Physiology, Associate Chair of Medicine Primary Appointment: Medicine GEBS Cluster Affiliations: CRMP- Cell Regulation and Molecular Pharmacology IBS - Integrative Biomedical Science
Research: Effects of Hydrogen Ions on Bone Calcium Homeostasis
Contact Information: E-Mail: David_Bushinsky@urmc.rochester.edu
University of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 675 Rochester, New York 14642	Medical Center [room] Phone: (716) [tele] Fax: (716) [number]

Research Overview

Our laboratory has two main areas of interest: the mechanisms by which hydrogen ions affect bone and the mechanism of hypercalciuria in our inbred strain of genetic hypercalciuric stone forming rats. We have found that acid induces calcium efflux from bone through both physicochemical and cell-mediated mechanisms, the latter involving suppression of immediate early response genes and genes controlling bone matrix formation. The hypercalciuria is due to a systemic disorder of calcium transport, thought to be secondary to an increase in vitamin D receptor number.

Recent Publications

Frick, K. K., L. Jiang and D. A. Bushinsky. Acute metabolic acidosis inhibits the induction of osteoblastic egr-1 and type 1 collagen. Am. J. Physiol. 272 (Cell Physiol. 41): C1450-C1456, 1997.

Yao, J., P. Kathpalia, D. A. Bushinsky and M. J. Favus. Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3: A new characteristic of genetic hypercalciuric stone-forming rats. J. Clin. Invest.: 101:2223-2232, 1998.

Frick, K and D. A. Bushinsky. Chronic metabolic acidosis reversibly inhibits extracellular matrix gene expression in mouse osteoblasts. Am. J. Physiol. (Renal Physiol. in press, 1998.

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GEBS Clusters:

CRMP

IBS