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Ph.D. (1995)
University of Rochester
M.S. (1992)
University of Rochester
D.D.S. (1980)
West Virginia University
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Gene
E. Watson II
Assistant Professor in the Eastman Department of Dentistry
and the Department of Pharmacology and Physiology and Director
of the Salivary Dysfunction Center
Primary Appointment:
Dentistry
GEBS Cluster Affiliations:
CRMP-Cell Regulation
and Molecular Pharmacology
COB-Center for
Oral Biology
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Research:
Diagnosis, treatment, and prevention of diseases of
salivary glands and salivary gland hypofunction |
Contact Information:
E-Mail: Gene_Watson@urmc.rochester.edu
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University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 705
Rochester, New York 14642
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Medical Center, Room 6-6835
Phone: (716) 275-7978
Fax: (716) 461-5420 |
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Research
Overview
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| Dr. Watson's research interests include the diagnosis,
treatment, and prevention of diseases of salivary glands and
salivary gland hypofunction. Because salivary hypofunction increases
risk of dental caries, he is also interested in the influence
of various agents, such as radiation, medication, and environment;
diseases on salivary function; and ultimately dental caries.
Dr. Watson has recently completed a study that determined
the efficacy of an intraoral fluoride releasing system to
prevent caries in irradiated cancer patients and participated
in a multi-center study examining pilocarpine treatment for
xerostomia in Sjögren's Syndrome. At present he is participating
in collaborative research with Dr. William Bowen, of the Center
for Oral Biology, examining the effects of lead and other
heavy metals on salivary glands and dental caries. He is also
working with Dr. Tom Clarkson of the Department of Environmental
Medicine, examining the contribution of amalgam restorations
to the total body burden of mercury. He is the site's principal
investigator for a multi-center phase three clinical study
to determine the efficacy of a low dose of natural interferon
alpha administered by the oral mucosal route for the treatment
of primary Sjögren's Syndrome.
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Recent Publications
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- Watson GE, Pearson SK, Bowen WH.
- The effect of chronic clonidine administration on salivary glands and
caries in the rat. Caries Res 2000;34:194-200.
- Raubertas RF, Davis BA, Bowen WH, Pearson SK, Watson GE.
- Litter effects on caries in rats and implications for
experimental design. Caries Res 1999;33:164-9.
- Meyerowitz C, Watson GE.
- The efficacy of an intraoral fluoride-releasing system
in irradiated head and neck cancer patients: a preliminary
study. J Am Dent Assoc 1998;129:1252-9.
- Watson GE, Davis BA, Raubertas RF, Pearson SK, Bowen WH.
- Influence of maternal lead ingestion on caries in rat
pups. Nat Med 1997;3:1024-5.
- Watson GE, Latchney LR, Luo W, Hand AR, Culp DJ.
- Biochemical and immunological studies and assay of rat sublingual
mucins. Arch Oral Biol 1997;42:161-72.
- Culp DJ, Luo W, Richardson LA, Watson GE, Latchney LR.
- Both M1 and M3 receptors regulate exocrine secretion by
mucous acini. Am J Physiol 1996;271:C1963-72.
- Watson GE, Culp DJ.
- Muscarinic cholinergic receptor subtypes in rat sublingual
glands. Am J Physiol 1994;266:C335-42.
- Gans RF, Watson GE, Tabak LA.
- A new assessment in vitro of human salivary lubrication
using a compliant substrate. Arch Oral Biol 1990; 35:487-92.
- Watson GE, Pearson SK, Falany JL, Tabak LA, Bowen WH.
- The effect of chronic propranolol treatment on salivary
composition and caries in the rat. Arch Oral Biol 1990;35:435-41.
- Watson GE, Pearson SK, Falany JL, Culp DJ, Tabak LA, Bowen
WH.
- The effect of chronic atropine treatment on salivary composition
and caries in rats, J Dent Res 1989;68:1739-45.
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