Ph.D.
Albany Medical College
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Wolfgang Haas, Ph.D.
Assistant Professor of Microbiology & Immunology
in the Center for Oral Biology
Primary Appointment:
Microbiology & Immunology
Center Affiliation:
Oral Biology
GEBS Cluster Affiliations:
IMV -
Immunology, Microbiology, and Virology
Contact Information:
- University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, New York 14642
KMRB, G-9649
Phone: (585) 275-7722
Fax: (585) 276-0190
E-Mail: wolfgang_haas@urmc.rochester.edu
Research: Antibiotic-Stress Response and Resistance in Streptococci |
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Streptococci cause various diseases in humans, ranging
from tooth decay to infections of the heart valves, lungs, brain, and
middle ear. These potentially fatal diseases are commonly treated with
antibiotics such as penicillin. The frequent use of antibacterial drugs
has sparked the emergence of bacterial strains that are resistant to
one or more antibiotics. Infections caused by multidrug resistant
strains might become untreatable in the future if no new antibacterial
agents are developed in time.
We are interested in the bacterial response to
antibiotic treatment in order to understand this type of stress
response and to determine new targets for antibacterial drugs.
Microarray analysis of mRNA from Streptococcus pneumoniae that had been
treated with the antibiotic vancomycin revealed a number of genes that
were differentially regulated. We are currently in the process of
determining the role of these gene products in the vancomycin-stress
response of S. pneumoniae. These studies give us information about new
targets for antibiotics and provide us with important insight into
bacterial gene regulation and physiology.
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Haas W, Kaushal D, Sublett J, Obert C, Tuomanen EI.
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae.
J Bacteriol. 2005 Dec;187(23):8205-10.
Gilmore, M. S. and W. Haas. "The selective advantage of microbial fratricide." Proc Natl Acad Sci U S A 102(24): 8401-2, 2005.
Coburn, P. S., C. M. Pillar, et al. "Enterococcus
faecalis senses target cells and in response expresses cytolysin." Science 306(5705): 2270-2, 2004.
Haas W, Sublett J, Kaushal D, Tuomanen EI.
Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance.
J Bacteriol. 2004 Dec;186(24):8463-71.
Shankar N, Coburn P, Pillar C, Haas W, Gilmore M.
Enterococcal cytolysin: activities and association with other virulence traits in a pathogenicity island.
Int J Med Microbiol. 293:609-18, 2004. Review.
Razeto A, Giller K, Haas W, Gilmore MS, Zweckstetter M,
Becker S. Expression, purification, crystallization and preliminary
crystallographic studies of the Enterococcus faecalis cytolysin
repressor CylR2.
Acta Crystallogr D Biol Crystallogr. 60:746-8, 2004.
Haas W, Shepard BD, Gilmore MS.
Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction.
Nature. 415:84-7, 2002.
Francia MV, Haas W, Wirth R, Samberger E,
Muscholl-Silberhorn A, Gilmore MS, Ike Y, Weaver KE, An FY, Clewell DB.
Completion of the nucleotide sequence of the Enterococcus faecalis
conjugative virulence plasmid pAD1 and identification of a second
transfer origin.
Plasmid. 46:117-27, 2001.
Haas W, Banas JA.
Ligand-binding properties of the carboxyl-terminal repeat domain of Streptococcus mutans glucan-binding protein A.
J. Bacteriol. 182:728-33, 2000.
Publication
list, as provided by PubMed.
PubMed is maintained by the National Library of Medicine and
provides complete abstracts of all publications, as well as
links to the full text of many articles (at journal homepages).
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