B8. Androgen Receptor Coregulators (Coactivator-Corepressor)

  1. Yeh S, and Chang C "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells." Proc. Natl. Acad. Sci. (1996):93(11):5517-21. PMID: 8643607.

  2. Miyamoto H, Yeh S, Kinoshita H, Fujimoto N, Nishimura K, Inui S, Mizokami A, Uemura H, and Chang C "Androgen receptor and androgen receptor cofactors in prostate." Proc. Jap. Nat. Conf. Andrology, (1997):1-4. PMID: none.

  3. Yeh S, and Chang C "The effect of androgens and 17²-estradiol on the androgen receptor transcriptional activity in the presence of the androgen receptor coactivator ARA70 in human prostate DU145 cells." from: Current Advances in Andrology (Waites G. Frick J and Baker G ed) (1997):pp. 17-22 Monduzzi Editore Italy.

  4. Yeh S, and Chang C "ARA70, Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells." Worldwide Documents in Prostatic Cancer & BPH (1997):5, 2-3. PMID: none.

  5. Yeh S, Miyamoto H, Shima H, and Chang C "From estrogen to androgen receptor: a new pathway for sex hormone in prostate." Proc. Natl. Acad. Sci. (1998): 95(10):5527-32.PMID: 9576916.

  6. Miyamoto H, Yeh S, Wilding G, and Chang C "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells." Proc. Natl. Acad. Sci. (1998) 5(13):7379-84. PMID: 9636157.

  7. Yeh S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, and Chang C "Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells." BBRC. (1998);248(2):361-7.PMID: 9675141.

  8. Miyamoto H, Yeh S, Huang S-B, Fugimoto N, Hsiao P, Ting H, Inui S, Nishimura K, Wang C, Uemura H, Kang H, and Chang C "The Androgen Receptor Coregulator ARA70." in Molecular Basis of Sex Hormone Receptor Function (Gronemeyer H, Fugymann U and Parczyk ed) (1998) pp. 43-51, Springer, Berlin.

  9. Kang HY, Yeh S, Fujimoto N, and Chang C "Cloning and characterization of human prostate coactivator, ARA54, a novel protein that associates with the androgen receptor." J. Biol. Chem. (1999):274(13), 8570-6. PMID: 10085091.

  10. Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK and Chang C. "Differential induction of androgen receptor transcriptional activity by selective androgen receptor coactivators." Keio J. Medicine (1999):48(2):87-92. PMID: 10405524.

  11. Heinlein CA, Ting H-J, Yeh S, and Chang C "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma." J. Biol. Chem. (1999):274(23), 16147-52. PMID: 10347167.

  12. Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, and Chang C "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells." Proc. Natl. Acad. Sci. (1999):96, 5458-63, PMID: 10318905.

  13. Hsiao P and Chang C "Isolation and characterization of ARA160 as an androgen receptor N-terminal associated coactivator in human prostate cells." J. Biol. Chem. (1999):274(32), 22373-9. PMID: 10428808.

  14. Hsiao P, Lin D, Nakao K, and Chang C "The linkage of the Kennedy's neuron disease to ARA24, the first identified androgen receptor poly-glutamine region-associated coactivator." J. Biol. Chem. (1999): 274(29):20229-34. PMID: 10400640.

  15. Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, and Chang C "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate." J. Biol. Chem. (1999):274(12), 8316-21, PMID: 10075738.

  16. Lee YF, Shyr CR, Thin TH, Lin WJ and Chang C "Convergence of two repressors through heterodimer formation of androgen receptor and TR4 orphan nuclear receptor: a new signaling pathway in the steroid receptor superfamily." Proc. Natl. Acad. Sci. (1999):96(26), 14724-9. PMID: 10611280.

  17. Yeh S, Kang H, Miyamoto H, Nishimura K, Chang H, Fujimoto N, Ting H, Mizokami A, Huang K, and Chang C"Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate DU145 cells." Endocrine (1999): 11(2):195-202. PMID: 10709768.

  18. Chang HC, Miyamoto H, Yeh S, Lardy H, and Chang C "Suppression of Delta5-Androstenediol-induced AR transactivation by selective steroids in human prostate cancer cells." Proc. Natl. Acad. Sci. (1999): 96(20):11173-7.PMID: 10500149.

  19. Miyamoto H, and Chang C "Antiandrogens fail to block completely the androstenedione-induced mutated androgen receptor transactivation in human prostate cancer cells." International J. Urology (2000): 7(1):32-4. PMID: 10701889.

  20. Nishimura K, Sampson E, Yan S, Kim E, Wang X, Uemura H, Wang C, Fujimoto N, Kang H, Yeh S, and Chang C "Yeast two-hybrid screening of associated proteins and characterization of mutant androgen receptors." (2000):329-343 in Yeast Hybrid Technologies (Zhu L and Hannon G ed). Eaton Publishing.

  21. Lee DK, Duan HO and Chang C "From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator." J. Biol. Chem. (2000): 275(13):9308-13.PMID: 10734072.

  22. Yeh S, Hu Y, Rahman M, Lin H, Ting H, Kang H, and Chang C "Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells." Proc. Natl. Acad. Sci. (2000):97, 11256-61, PMID: 11016951.

  23. Yeh S, Sampson E, Lee DK, Kim E, Hsu C, Chen Y, Chang HC, Altuwaijri S, Huang K, and Chang C "Functional analysis of N-terminal and Ligand-binding domain of androgen receptor coactivators in prostate cancer." J. Formosan Medical Association (2000): 99(12):885-94.PMID: 11155740.

  24. Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, and Chang C "From TGF-_ signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells." Proc. Natl. Acad. Sci. (2001):98, 3018-23, PMID: 11248024.

  25. Lee DK, Duan HO, and Chang C "Androgen receptor interacts with the positive elongation factor P-TEF_ and enhances the efficiency of transcriptional elongation." J. Biol. Chem (2001): 276(13):9978-84. PMID: 11266437.

  26. Lin H, Yeh S, Kang H, and Chang C "Akt suppresses androgen-induced apoptosis by phosphorylatiing and inhibiting androgen receptor." Proc. Natl. Acad. Sci. (2001):98, 7200-5. PMID: 11404460.

  27. Heinlein CA, and Chang C "The role of chaperones in the nuclear translocation and transactivation of steroid receptors." Endocrine (2001):14(2), 143-9. PMID: 11394630.

  28. Sampson E, Yeh S, Chang H, Tsai M, Wang X, Ting H-J, and Chang C "Identification and characterization of androgen receptor associated coregulators in prostate cancer cells." J. Biological Regulation & Homeostatic Agents (2001): 15(2):123-9. PMID: 11501969.

  29. Wang X, Yeh S, Wu G, Hsu C, Wang L, Chiang T, Yang Y, Guo F, and Chang C "Cloning and characterization of androgen receptor coregulator, ARA267-__in prostate cancer cells." J. Biol. Chem. (2001): 276(44):40417-23. PMID: 11509567.

  30. Miyamoto H, Rahman M, Takatera H, Kang H, Yeh S, Chang H, Nishimura K, Fujimoto N, and Chang C "A dominant-negative mutant of androgen receptor coregulator, ARA54 inhibits androgen receptor-mediated prostate cancer growth." J. Biol. Chem. (2002):277, 4609-17. PMID:11673464.

  31. Heinlein C and Chang C "Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity." pp 57-90 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). (2002):Kluwer, USA.

  32. Heinlein C, Sampson E and Chang C "Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors." pp 91-138 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). (2002):Kluwer, USA.

  33. Ting H, Yeh S, Nishimura K, and Chang C "Supervillin associated with androgen receptor and modulates its transcriptional activity." Proc Natl. Acad. Sci (2002):99, 661-6. PMID:1172840.

  34. Hsing AW, Chokkalingam AP, Gao YT, Wu G, Wang X, Deng J, Cheng J, Sesterhenn IA, Mostofi FK, Chiang T, Chen YL, Stanczyk FZ and Chang C. "Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study.." Cancer Epidemiol Biomarkers Prev. (2002):11(4);337-41.PMID: 11927493.

  35. Wang X, Yang Y, Guo X, Sampson E, Hsu CL, Tsai MY, Wu G, Guo Y and Chang C "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator." J. Biol. Chem. (2002):277, 15426-31. PMID:11856738.

  36. Heinlein CA, and Chang C "Androgen receptor coregulator: an overview." Endocrine Review. (2002):23(2), 175-200. PMID: 11943742.

  37. Lin HK, Wang L, Hu YC, Altuwaijri S and Chang C "Phosphorylation-dependent ubiquitination and degradation of AR by Akt requires Mdm2 E3 ligase." EMBO (2002):21, 1-12. PMID:12145204.

  38. Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collin L, Basavappa R, and Chang C "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17_-estradiol-induced androgen receptor transactivation." J. Biol. Chem. (2002):277(39):36499-508. PMID:12068007.

  39. Hsing A, Culig Z, Wang X, Uemura H and Chang C "The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications." pp 245-264 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). (2002):Kluwer, USA.

  40. Sampson E, Yeh S. Miyamoto H, Lee DK, Tsi, MY, Wang X, Hsu CL, and Chang C "Interaction of cell cycle regulatory proteins with the androgen receptor." pp 223-238 in Steroid hormones and cell cycle regulation. (Burnstein KL ed). (2002):Kluwer, USA.

  41. Lin HK, Hu YC, Altuwaijri S, Lin WJ ,Kan PY, Collins L, and Chang C "Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells." J. Biol. Chem. (2002):277, 36570-6. PMID:12119296.

  42. Lee Y, Lin WJ, Huang J, Messing E, C Kuo, Wilding G, and Chang C "Activation of MAP kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor negative prostate cancer cells." Cancer Research (2002):62, 6039-44. PMID:12414626.

  43. Kang H, Huang KE, Chang S, Ma WL, Lin WJ and Chang C "Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4." J. Biol. Chem. (2002): 277, 43749-56. PMID:12226080.

  44. Lee DK and Chang C "Molecular communication between androgen receptor and general transcription machinery." JSBMB (2003):84(1), 41-9. PMID: 12648523.

  45. Rahman MM, Miyamoto H, Takatera H, Yeh S, Altuwaijri S and Chang C "Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 mutant in prostate cancer cells." J. Biol. Chem. (2003):278(22),19619-26. PMID:12649293.

  46. Rahman MM, Miyamoto H, Lardy H and Chang C "Inactivation of androgen receptor (AR) coregulator ARA55 leads to an inhibition of AR transactivation and a reduction of the agonist activity of antiandrogens in prostate cancer cells." Proc Natl. Acad. Sci. (2003):100(9), 5124-9. PMID:12700349.

  47. Lee DK, Li M and Chang C "The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor." BBRC (2003):302(1), 162-9. PMID: 12593864.

  48. Yang L, Lin HK, Altuwaijri S, Xie S and Chang C "APPL suppresses androgen receptor transactivation via potentiating Akt activity." J. Biol. Chem. (2003):278(19), 16820-7. PMID:12621049.

  49. Hsu CL, Yeh S, Chen YL, Ting HJ, Hu YC, Hank L, Wang X and Chang C "The use of phase display technique for the isolation of androgen receptor interacting peptides with F/WXXLF/W and FXXLY new signature motifs." J. Biol. Chem. (2003):278, 23691-23698. PMID:12714604.

  50. Yang L, Wang L, Lin HK, Kan P, Xie S, Tsai MY, Wang PH, Chen YT and Chang C "Interleukin-6 differentially regulates androgen receptor transavtivation via PI3K-Akt, STAT3 and MAPK three distinct signal pathways in prostate cancer cells." BBRC. (2003):305(3), 462-9. PMID: 12763015.

  51. Heinlein CA, and Chang C "Induction and Repression of Peroxisome Proliferator-Activated Receptor alpha (PPAR±) Transcription by the Coregulator ARA70." Endocrine (2003):21(2), 139-46. PMID: 12897377.

  52. Nishimura K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Shin M, AozasaK, Okuyama A and Chang C "Modulation of androgen receptor transactivation by gelsolin: A new identified AR coregulator" Cancer Research. (2003):63, 4888-94. PMID:12941811.

  53. Altuwaijri S, Lin HK, Chuang KH, Lin WJ, Yeh S, Hanchett L, Rahman MM, Kang HY, Tsai MY, Zhang Y, Yang L, and Chang C "Interruption of NFkB Signaling by Androgen Receptor Facilitates TPA-induce apoptosis in an Androgen Sensitive Prostate Cancer Cell Line." Cancer Research. (2003):63, 7106-12. PMID:146503.

  54. Fu M, Rao M, Wang C, Sakamaki T, Wang J, Vizio DD, Zhang X, Albanese C, Balk S, Chang C, Fan S, Rosen E, Palvimo J, Janne O, Muratoglu S, Avantaggiati ML and Pestell RG "Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth." MCB. (2003):23(23), 8563-73. PMID: 14612401.

  55. Lin H, Hu W, Yang L, Altuwaijri S, Chen YT, Kang HY and Chang C "Suppression vs induction of androgen receptor by the PI3K/Akt pathway in prostate cancer LNCaP cells with different passage numbers." J. Biol. Chem. (2003):19, 50902-7. PMID: 14555644.

  56. Rahman M, Miyamoto H, and Chang C "Androgen Receptor Coregulators in Prostate Cancer Progression: Mechanisms and Clinical Implications." Clinical Cancer Research. (2004):10(7), 2208-19. PMID: 15073094.

  57. Zhang Y, Yang Y, Yeh S and Chang C "ARA67 functions as a repressor to suppress androgen receptor transactivation." MCB. (2004):24, 1044-57. PMID:14729952.

  58. Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Ken P and Chang C "Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells" MCB. (2004):24, 2202-13. PMID:14966297.

  59. Yang L, Yeh SD, Xie S, Altuwaijri S, Ni J, Hu YC, Chen YT, Bao BY, Su CH and Chang C "Androgen suppresses PML protein expression in prostate cancer CWR22R cells" BBRC (2004):314(1), 69-75. PMID: 14715247.

  60. Xie S, Lin HK, Ni J, Wang L, Yang L, di Sant'Agnese PA, and Chang C "Regulation of interleukin-6 mediated P13K activation and neurendocrine diffrentiation by androgen signaling in prostate cancer LNCaP cells." The Prostate. (2004):60(1), 61-7. PMID: 15129430.

  61. Wang L, Lin HK, Hu YC, Mu X, Xie S, and Chang C "Glycogen Synthase Kinase 3² Negatively Regulates Androgen Receptor-Dependent Transcription and Cell Growth." JBC. (2004):279, 32444-52. PMID:15178691.

  62. Lin H, Hu W, Lee K and Chang C "Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells." Mol.Endo.(2004):18, 2409-23. PMID:15205473.

  63. Hu YC, Yeh S, Yeh SD, Sampson E, Li P, Hsu CL, Ting H, Lin H, Wang L, Kim E and Chang C "Functional Domain and Motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer." JBC (2004):279, 33438-46. PMID:15166229.

  64. Ting HJ, Hu YC, and Chang C "Actin monomer enhances supervillin-modulated androgen receptor transactivation." BBRC (2004):319(2), 393-6. PMID: 15178419.

  65. Wang l, Hsu CL and Chang C "Androgen receptor corepressors: an overview." The Prostate. (2005):63(2), 117-30. PMID: 15486994.

  66. Yang L, Xie S, Jamaluddin MS, Altuwaijri S, Ni J, Kim E, Chen YT, Hu YC, Wang L, Chuang KH, Wu CT, Chang C "Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells." JBC. (2005):280(39):33558-65. PMID: 16061480.

  67. Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YY and Chang C "9-Cis-Retinoic Acid Inhibits Androgen Receptor Activity Through Activation of Retinoid X Receptor." Mol Endo. (2005):19(5):1200-12. PMID:15650026.

  68. Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, Sant'Agnese A and Chang C "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth" Mol. Endo. (2006):21(2):343-58. PMID:17082327.

  69. Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao YL, di Sant'Agnese PA, Tsai MY, and Chang C "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonuleoprotein A1 via interaction with AR coregulator ARA54" Endocrinology. (2006):148(3):1340-9. PMID:17227886.

  70. Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Hu YC, Tsai MY, Yeh S, Messing E and Chang C "Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals" JNCI, (2007):99: 558 - 68. PMID: 17406000.

  71. Niu Y, Yeh S, Miyamoto H, Li G, Altuwaijri S, Yuan J, Han R, Ma T, Kuo HC and Chang C "Tissue prostate specific antigen (PSA) facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation" Cancer Research., (2008):68: (17), 7110-19. PMID:1857426. PMC2587124. NIHMSID # 58471.

  72. Ting HJ and Chang C "Actin Associated Proteins Function as Androgen Receptor Coregulators: An Implication of Androgen Receptor's Roles in Skeletal Muscle" The Journal of Steroid Biochemistry and Molecular Biology. (2008):111(3-5):157-63. PMID: 18590822.

  73. Niu Y, Altuwaijri S, Yeh S, Lai KP, Yu S, Chuang KH, Huang SP, Lardy H and Chang C "Targeting the stromal androgen receptor in primary prostate tumors at earlier stages" PNAS, (2008):105(34):12188-93. PMID:18723670. PMC2527887

  74. Shyr CR, Tsai MY, Yeh S, Kang HY, Chang YC, Wong PL, Huang CC, Huang KE and Chang C "Tumor suppressor PAX6 functions as androgen receptor Co-repressor to inhibit prostate cancer growth" Prostate. (2009). PMID: 19790232

 

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