B9 Androgen Receptor Knockout Mice (ARKO) for AR in vivo roles in individual cell

  1. Yeh S, Tsai MY, Xu Q, Mu X, lardy H, Huang KE, Lin H, Yeh SD, Altuwaijrl S, Zhou X, Xing L, Boyce B, Hung MC, Zhang S, Gan L and Chang C "Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues." Proc Natl. Acad. Sci. (2002):99,13498-503. PMID: 12370412.

  2. Yeh S, Hu YC, Wang PH, Xie C. Xu Q, Zhou X, Tsai MY, Dong Z, and Chang C "Abnormal mammary gland development and growth retardation in breast cancer MCF7 cells and female mice lacking androgen receptor." J. Experimental Medicine (2003):198, 1899-908. PMID:14676301.

  3. Hu YC, Wang PH, Hu YC, Yeh S, Xie C, Zhou X, Xu Q, Chao HT, Tsai MY, and Chang C "Subfertility and defective folliculogenesis in female mice lacking androgen receptor." Proc Natl. Acad. Sci. (2004):101, 11209-14. PMID:15277682.

  4. Lin H, Xu Q, Yeh S, Wang RS, Sparks JD and Chang C "Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor." Diabetis (2005):54, 1717-25. PMID:15919793.

  5. Wu C, Yeh S, Xu Q, Yang Z, Chang P, Yu Y, and Chang C "Study of androgen receptor roles in prostate cancer using mice lacking functional prostate androgen receptor" pp 223-238 in Prostate Cancer: Basic Mechanisms and Therapeutic Approaches. (Chang C ed). (2005):World Scientific. USA.

  6. Zhang C, Yeh S, Chen YT, Wu CC, Chuang KH, Lin HY, Wang RS, Chang YJ, Mendis C, Hu L, Lardy H and Chang C "Oligozoospermia with Normal Fertility in Male Mice Lacking the Androgen Receptor in Testis Peritubular Myoid Cells" PNAS. (2006):103(47):17718-23. PMID: 1709560

  7. Wu CT, Altuwaijri S, Ricke WA, Huang SP, Yeh S, Zhang C, Niu Y, Tsai MY , and Chang C "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor" PNAS . (2007):104(31):12679-84. PMID:17652515.

  8. Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S and Chang C. "Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells." Endocrine (2007): 32(1):96-106. PMID: 17955388.

  9. Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S and Chang C. "Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue." Endocrinology. (2008): 47(6):1924-35. PMID: 18449947.

  10. Niu Y, Altuwaijri S, Lai KP, Wu CT, Ricke WA, Messing EM, Yao J, Yeh S and Chang C "Androgen receptor is a tumor suppressor and proliferator in prostate cancer", PNAS, (2008):105(34):12182-7. PMID:18723679. PMC2527886.

  11. Niu Y, Altuwaijri S, Yeh S, Lai KP, Yu S, Chuang KH, Huang SP, Lardy H and Chang C "Targeting the stromal androgen receptor in primary prostate tumors at earlier stages" PNAS, (2008):105(34):12188-93. PMID:18723670. PMC2527887.
  12. Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S and Chang C "Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor" Hepatology, (2008):47(6):1924-35. PMID: 18449947.

  13. Ma WL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S and Chang C "Androgen Receptor Is a New Potential Therapeutic Target for the
    Treatment of Hepatocellular Carcinoma", Gastroenterology, (2008):135(3):947-55. PMID:18639661. NIHMS#69375,

  14. Kang HY, Shyr CR, Huang CK, Tsai MY, Orimo H, Lin PC, Chang C (corresponding author) and Huang KE "Altered TNSALP expression and phosphate regulation contribute to reduced mineralization in mice lacking androgen receptor" MCB, (2008): 28(24): 7354-67. PMID: 18838539.

  15. Chen M, Hsu I, Wolfe A, Radovick S, Huang K, Yu S, Chang C, Messing EM and Yeh S."Defects of Prostate Development and Reproductive System in the ER{alpha} Null Male Mice." Endocrinology. (2009): 150(1):251-9, PMID: 18755802.

  16. Chen M, Wolfe A, Wang X, Chang C, Yeh S, Radovick S."Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology" MCB (2009): 321(1-2):145-53, PMID: 18953638.

  17. Altuwaijri S, Chuang KH, Lai KP, Lai JJ, Lin HY, Young FM, Bottaro A, Tsai MY, Yeh S and Chang C “Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells” Mol. Endo. (2009); 23(4):444-53. PMID: 19164450

  18. Wang RS, Yeh S, Tzeng CR, and Chang C “Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice” Endocr Rev. (2009); 30(2):119-32. PMID: 19176467

  19. Chuang KH, Altuwaijri S, Li G, Lai JJ, Chu CY, Lin YH, Lai KP, Hsu JW, Kang P, Wu MC, and Chang C “Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor” JEM, (2009);206(5):1181-99. PMID: 19414555.

  20. Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Wen-Jye Lin, and Chang C "Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression" JCI (2009). 119(12):3739-51. PMID: 19907077.Click the following links to see those reports from English newspaper
  21. Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S and Chang C " Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription" Sci Transl Med. 2010 May 19;2(32):32ra35.PMID: 20484730. Click the following links to see TV interviews 1,TV interviews 2,TV interviews 3 , English online news, Chinese Newspaper and Chinese online news.

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