C. TR2/ TR4 Nuclear Receptors

  1. Chang C, and Kokontis J "Identification of a new member of steroid receptor superfamily by cloning and sequence analysis." BBRC, (1988):155(2), 971-7. PMID: 3421977..

  2. Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y "Molecular cloning of new human TR2 receptors: A class of steroid receptor with multiple ligand-binding domains." BBRC. (1989):165(2), 735-41. PMID: 2597158.

  3. Chang C, Lau L, Liao S, and Kokontis J "Characterization of new members of steroid receptor superfamily." in The Steroid/Thyroid Hormone Receptor Family and Gene Regulation. (Gustafsson JA, Eriksson H, and Carlstedt-Duke J eds.) (1989):183-195, Congressdruck R. Bruckner, Berlin, Burkhauser Verlag Basel

  4. Kokontis J, Nakamoto T, and Chang C "Structural analysis and gene expression of TR2 receptor and TR3 receptor." Molecular and Cellular Biology of Prostate Cancer, (1991):229-234. Plenum, New York.

  5. Chang C, Da Silva SL, Ideta R, Lee Y-F, Yeh S, and Burbach JP "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily." PNAS (1994): 91(13):6040-4. PMID: 8016112. PMC44133.

  6. Ideta R, Yeh S, Lee YF, Adachi K, Takeda H, Su C, Saltzman A and Chang C "Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily." Endocrine, (1995):3, 277-83. PMID: none.

  7. Lopes da Silva S, Van Horssen AM, Chang C, Burbach JP "Expression of nuclear hormone receptors in the rat supraoptic nucleus." Endocrinology, (1995):136(5), 2276-2283. PMID: 7720676.

  8. Lee HJ, and Chang C "Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the Simian Virus 40 major late promoter." J. Biol. Chem. (1995):270(10), 5434-40. PMID: 7890658.

  9. Lin TM, Young WJ, and Chang C "Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system." J. Biol. Chem. (1995):270(50), 30121-8. PMID: 8530418.

  10. Lee HJ, Lee Y, Burbach P, and Chang C "Suppression of gene expression on the Simian Virus 40 major late promoter by human TR4 orphan receptor: a member of steroid receptor superfamily." J. Biol. Chem. (1995):270(50), 30129-33. PMID: 8530419.

  11. Lee HJ, Young WJ, Shih CY and Chang C "Suppression of the human erythropoietin expression gene by the TR2 orphan receptor: a member of steroid receptor superfamily." J. Biol. Chem. (1996):271(17), 10405-12. PMID: 8626614.

  12. Lin DL, and Chang C "P53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of steroid receptor superfamily." J. Biol. Chem. (1996): 71(25):14649-52.PMID: 8663350.

  13. Young WJ, Smith SM, and Chang C "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFR) ± gene by the TR4 orphan receptor." J. Biol. Chem. (1997):272(5), 3109-16. PMID: 9006963.

  14. Lee YF, Pan HJ, Burbach JP, Morkin E, and Chang C "Identification of direct-repeat 4 as a positive regulatory element for the human TR4 orphan receptor: a modulator for the thyroid hormone target genes." J. Biol. Chem. (1997):272(18), 12215-20. PMID: 9115296.

  15. Chang C, Lee HJ, Lee YF "Identification of the human aldolase A gene as the first induced target for the human TR2 orphan receptor: a member of the steroid hormone receptor superfamily." Biomed. Biophysic. Res. Commun. (1997):235(1), 205-11. PMID: 9196064.

  16. Lin DL Wu SQ, and Chang C "The genomic structure and chromosomal location of the human TR2 orphan receptor: a member of steroid receptor superfamily." Endocrine (1998): 8(2):123-34. PMID: 9704569.

  17. Lee YF, Young WJ, Burbach JP, and Chang C "Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor: a member of steroid receptor superfamily." J. Biol. Chem. (1998):273(22), 13437-43. PMID: 9593676.

  18. Hwang SB, Burbach JP, and Chang C, "TR4 orphan receptor crosstalks to chicken ovalbumin upstream protein-transcription factor and thyroid hormone receptor to induce the transcriptional activity of the human immunodeficiency virus type-1 long terminal repeat." Endocrine (1998): 8(2), 169-75. PMID: 9704574.

  19. Chang C, and Pan, HJ "Thyroid hormone direct repeat 4 response element is a positive regulatory element for the human TR2 orphan receptor, a member of the steroid receptor superfamily." MCB. (1998):189(1-2), 195-200. PMID: 9879671. tion of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes." J. Investigative Dermatology (1999) :112(4), 426-31. PMID: 10201524.

  20. Lee HJ, Lee YF, and Chang C "Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor." MCB. (1999):194(1-2), 199-207. PMID: 10391141.

  21. Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ, Boothman DA. "Isolation of Ku70-binding proteins (KUBs)." Nucleic Acid Res. (1999):27(10), 2165-74. PMID: 10219089.

  22. Lee YF, Shyr CR, Thin TH, Lin WJ and Chang C "Convergence of two repressors through heterodimer formation of androgen receptor and TR4 orphan nuclear receptor: a new signaling pathway in the steroid receptor superfamily." Proc. Natl. Acad. Sci. (1999):96(26), 14724-9. PMID: 10611280.

  23. Lin D, and Chang C "Identification and characterization of an essential cis-acting element (TR2-PACE) in the 5' promoter of human TR2 orphan nuclear receptor gene." Endocrine (2000): 12(1):89-97.PMID: 10855696.

  24. van Schaick HS, Rosmalen JG, Lopes da Silva S, Chang C, Burbach JP. "Expression of the orphan receptor TR4 during brain development of the rat." Brain Res Mol Brain Res. (2000);77(1):104-10. PMID: 10814836.

  25. Mu X, Liu Y, Collins L, Kim E, and Chang C "The p53/Rb-mediated repression of testicular orphan receptor-2 in the rhesus monkey with crytorchidism." J. Biol. Chem. (2000): 275(31):23877-83. PMID: 10811662.

  26. Collins L, Lin D, Mu X, and Chang C "Feedback regulation between orphan nuclear receptor TR2 and human papilloma virus type 16." J. Biol. Chem. (2001): 276(29):27316-21. PMID: 11358973.

  27. Lee HJ, Lee YF, and Chang C "TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif." Biochem. Biophys. Res. Commun. (2001):285(5), 1361-8. PMID: 11478808.

  28. Shyr C, Hu YC, Kim ES, and Chang C "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in breast cancer MCF-7 cells." J. Biol. Chem. (2002):277, 14622-8. PMID:11844790.

  29. Shyr C, Collins L, Mu XM, Platt KA and Chang C "Spermatogenesis and testes development are normal in mice lacking the testicular orphan nuclear receptor-2 (TR2)." MCB. (2002):22, 4661-6. PMID:12052874.

  30. Hu YC, Shyr CR, Che S, Mu XM, Kim E and Chang C "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor." J. Biol. Chem. (2002):277(37), 33571-9. PMID: 12093804.

  31. Lee YF, Lee HJ and Chang C "Recent advances in the TR2 and TR4 orphan receptors of nuclear receptor superfamily." JSBMB (2002): 81(4-5):291-308. PMID: 12361719.

  32. Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH and Chang C "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4." J. Biol. Chem. (2003):278, 9353-60. PMID:12522137.

  33. Yang Y, Wang X, Dong T, Kim E, Lin WJ and Chang C "Identification of a novel TR4 orphan receptor associated protein (TRA16) as repressor for the selective suppression of TR4-mediated transactivation." J. Biol. Chem. (2003):278, 7709-17. PMID:12486131.

  34. Kim E, Xie S, Lee YF, Collins L, Hu YC, Shyr CR, Mu XM, Liu NC, Chen YT, Wang PH, and Chang C "ApoE-TR4 orphan nuclear receptor induces the expression of liver apolipoprotein E/C-I/C-II gene cluster via hepatic control region." J. Biol. Chem. (2003):278, 46919-46926. PMID:12954636..

  35. Inui S, Lee YF, Chang E, Shyr CR and Chang C "Differential and bidirectional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor ± (PPAR±) in human HaCaT keratinocytes." J. of Dermatology Science (2003):31(1):65-71. PMID: 12615366.

  36. Mu X and Chang C "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3." The Prostate. (2003):57(2), 129-33. PMID: 12949936.

  37. Mu X, Liu NC, Chen YT, Collins L, Kim E, Shyr CR, Lee YF and Chang C "Target inactivation of TR4 orphan receptor delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis" MCB. (2004):24, 5887-99. PMID:15199144.

  38. Collins L, Lee YF, Lin WJ, Heinlein CA, Liu NC, Chen YT, Chen Y, Shyr CR, Meshul CK, Uno H, Chou S, Platt KA and Chang C "Growth retardation and abnormal female maternity in mice lacking testicular orphan nuclear receptor 4." PNAS. (2004):101. 15058-63. PMID: 15477591..

  39. Lee YF, Bao BY and Chang C "Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan receptor." BBRC. (2004):323(3), 876-83. PMID: 15381082.

  40. Kim E, Yang Z, Liu B and Chang C "Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region." BBRC. (2005):328(1), 85-90. PMID: 15670754.

  41. Chen YT, Collins LL, Uno H and Chang C "Deficits in Motor coordination with Aberrant Cerebellar Development in Mice Lacking Testicular Orphan Nuclear Receptor 4." MCB. (2005):25, 2722-32. PMID:15767677.

  42. Mu X, Yang L, and Chang C "Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis." BBRC. (2006):341(2), 464-9. PMID: 16414012.

  43. Wang CP, Lee YF, Chang C and Lee HJ "Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor" BBRC. (2006):351(1), 204-208. PMID: 17054912.

  44. Zhang Y, Chen YT, Xie S, Wang L, Lee YF, Chang SS and Chang C "Loss of Testicular Orphan Receptor 4 Impairs Normal Myelination in Mouse Forebrain" Mol. Endo. (2007):21(4):908-20. PMID: 17227886.

  45. Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD."Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4" EMBO. (2007):2; 26(9):2295-306. PMID: 17431400.

  46. Chen YT, Collins LL, Uno H, Chou SM, Meshulf CK, Chang SS and Chang C "Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor" Brain Research, (2007):1168:72-82. PMID:2084075.

  47. Chen YT, Collins LL, Chang SS and Chang C "The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development". Cerebellum. (2008);7(1):9-17. PMID: 18418664.

  48. Kim E, Ma WL, Lin DL, Inui S, Chen YL, and Chang C "TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression". BBRC. (2007):361(2):323-8. PMID: 17655826.

  49. Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF and Chang C "Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase-Mediated Gluconeogenesis" Diabetes (2007):56:2901-9. PMID:17827404.

  50. Chen LM, Wang RS, Lee YF, Liu NC, Chang YJ, Wu CC, Xie S, Hung YC and Chang C. "Subfertility with Defective Folliculogenesis in Female Mice Lacking TR4 Orphan Nuclear Receptor" Mol Endo, (2008):22(4):858-67. PMID:1874360.

  51. Li G, Lee YF, Liu S, Cai Y, Xie S, Liu NC, Bao BY, Chen Z and Chang C. "Oxidative Stress Stimulates TR4 Orphan Receptor through Forkhead Transcription Factor FOXO3a" Endocrinology. (2008):149(7):3490-9. PMID: 18388194.

  52. Shyr CR, Kang HY, Tsai MY, Liu NC, Ku PY, Huang KE and Chang C. “Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells’ Endocrinology, (2009) 2009. 150(5):2454-2462. PMID: 19131575.

  53. Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe JI, Berk B, Ho FM and Chang C "TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation" PNAS (2009): 106(32):13353-8.PMID: 19666541

 

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