B3. Androgen Receptor in Tfm/ AIS, Male Fertility and Testis Spermatogenesis

  1. Sai T, Seino S, Chang C, Trifiro M, Pinsky L, Mhatre A, Kaufman, M, Lambert B, Trapman J, Brinkmann AO, Rosenfield RL, and Liao S "An exonic point mutation of the androgen receptor gene in a family with complete androgen insensitivity." American Journal of Human Genetics, (1990):46(6), 1095-100. PMID: 2339702. PMC1683844.

  2. Imperato-McGinley J, Ip NY, Gautier T, Neuweiler J, Gruenspan H, Liao S, Chang C, and Balazs I "DNA linkage analysis and studies of the androgen receptor gene in a large kindred with complete androgen insensitivity." American Journal of Medical Genetics, (1990):36(1), 104-8. PMID: 2333898.

  3. Trifiro M, Gottlieb B, Pinsky L, Kaufman M, Prior L, Belsham DD, Wrogemann K, Brown CJ, Willard HF, Trapman J, Brinkmann AO, Chang C, Liao S, Sergovich F, and Jung J "The 56/58 kDa androgen-binding protein in male genital skin fibroblasts with a deleted androgen receptor gene." Molecular and Cellular Endocrinology, (1991):75(1), 37-47. PMID: 2050265.

  4. Mestayer C, Gabou L, Portois MC, Boucekkine C, Chang C, and Mowszowicz I. "Expression du gene durpecepteur des androgenes chez des sujets normaux et des patients presentant une insensibilite complete aux androgenes." Annales d'Endocrinologie (1991):52, 431-4. PMID: none.

  5. Sanborn BM, Caston LA, Chang C, Liao S, Speller R, Porter LD, and Ku CY "Regulation of androgen receptor mRNA in rat sertoli and peritubular cells." Biology Reproduction, (1991):45(4), 634-41. PMID: 1751639.

  6. Prior L, Bordet S, Trifiro MA, Mhatre A, Kaufman M, Pinsky L, Wrogeman K, Belsham DD, Pereira F, Greenberg C, Trapman J, Brinkmann AO, Chang C, and Liao S "Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes." American Journal of Human Genetics, (1992):51(1), 143-55. PMID: 1609793. PMC1682864.

  7. Kaku A, Chang C, Tamura T, Okamoto T, and Yoshimura Y. "Immunolocalization of androgen receptor in the cloacal gland of male Japanese quail (Coturnis coturnix japonica)." Japanese Poultry Science, (1993):30, 413-418. PMID: none.

  8. Mowszowicz I, Lee HJ, Chen HT, Mestayer C, Portois MC, Carbrol S, Mauvais-Jarvis P, and Chang C "A point mutation in the second zinc-finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance." Mol. Endocrinology. (1993):7(7), 861-9. PMID: 8413310.

  9. Mowszowicz I, Lee H-J, Portois M-C, Kuttenn F, and Chang C "Complete androgen insensitivity due to a single base substitution in exon 8 of the steroid-binding domain of the androgen receptor." Endocrine, (1993):1, 203-9. PMID: none.

  10. Lee HJ, Mowszowicz I, and Chang C "The first detection of complete androgen insensitivity with no mutation in the coding sequence of the androgen receptor gene." Frontiers in Bioscience (1996):1: a34-8. PMID: 9159192.

  11. Collins L and Chang C "Androgens in Spermatogenesis and Contraception." pp 299-324 in Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. (Chang C ed). (2002):Kluwer, USA.

  12. Collins L, Lee H, Chen YT, Yeh S and Chang C "Androgen receptor in spermatogenesis." Cytogenetic and Genome Research (2003):103(3-4), 289-301. PMID: 15051951.

  13. Chang C, Chen YT, Yeh SD, Xu Q, Guillou F, and Yeh S "Infertility with defective spermatogenesis and hypotestosteronemia in mice lacking androgen receptor in Sertoli cells." Proc Natl. Acad. Sci. (2004):101(18), 6876-81. PMID:15107499.

  14. Wang RS, Yeh S, Chen LM, Lin HY, Zhang C, Ni J, Wu CC, di Sant'agnese PA, de Mesy-Bentley KL, Tzeng CR, and Chang C" Androgen Receptor in Sertoli Cell Is Essential For Germ Cell Nursery and Junctional Complex Formation in Mouse Testes" Endocrinology. (2006):147(12):5624-33. PMID: 16973730.

  15. Tsai MY, Yeh SD, Wang RS, Yeh S, Zhang C, Lin HY, Tseng CR and Chang C "Differential Effects of Spermatogenesis and Fertility in Mice Lacking Androgen Receptor in Individual Testis Cells" PNAS . (2006):103(50):18975-80. PMID: 17142319.

  16. Zhang C, Yeh S, Chen YT, Wu CC, Chuang KH, Lin HY, Wang RS, Chang YJ, Mendis C, Hu L, Lardy H and Chang C "Oligozoospermia with Normal Fertility in Male Mice Lacking the Androgen Receptor in Testis Peritubular Myoid Cells" PNAS. (2006):103(47):17718-23. PMID: 17095600.

  17. Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S and Chang C. "Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells." Endocrine (2007): 32(1):96-106. PMID: 17955388.

  18. Wang RS, Yeh S, Tzeng CR, and Chang C “Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice” Endocr Rev. (2009); 30(2):119-32. PMID: 19176467

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