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Dr. Chang's Publications

Total 380 published papers: including 1NatureMedicine/2Science-ScienceTM/1Lancet/2JCI-JNCI/2JEM/5EMBO-MolMed/27PNAS/50JBC/10MCB/10Cancer Research and >200 in Endocrinology or Cancer related Journals. . Citation indices from Google Scholar: (Citations: 21826; H-index: 77; i10-index: 249)

Please see detail of each published papers in PubMed. For 35 AR review articles, please see below for PDF files.

AR Reviews


  1. Yeh S, Lee SO and Chang C “Targeting androgens vs androgen receptor to battle prostate cancer” , (2014) submitted
  2. Ma WL, Lai HC, Yeh S, Cai X and Chang C “Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis” Endocr Relat Cancer. 2014 Jan 14. [Epub ahead of print] PMID: 24424503
  3. Chang C, Lee SO, Yeh S and Chang TM “Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells” Nuclear Receptor Signaling, (2013) 11:e001, PMID: 24653668; PMCID:PMC3960937
  4. Chang C, Lee SO, Yeh and Chang TM “Androgen receptor physiological roles in male and female reproductive system: what we learned from ARKO mice lack AR in selective cells” Biol Reprod (2013) 89(1):21. PMID:23782840
  5. Chang C, Lee SO, Yeh S and Chang TM “Androgen Receptor (AR) Roles in Hormone-related Tumors including Prostate, Bladder, Kidney, Lung, Breast and Liver” Oncogene, (2013), PMID: 23873027
  6. Wen S, Niu Y, Lee SO, and Chang C “Androgen Receptor Positive vs Negative Roles in Prostate Cancer Cell Death including Apoptosis, Anoikis, Entosis, Necrosis and Autophagic Cell Death” Cancer Treatment Review, (2013) S0305-7372(13)00139-4. PMID: 23993415
  7. Izumi K, Mizokami A, Lin WJ, Lai KP and Chang C “Androgen receptor roles in the benign prostate hyperplasia (BPH) development” Am J Pathol, (2013) 182(6): 1942-1949. PMID: 23570837
  8. Ding XF, Yu SC, Chen BD, Lin SJ, Chang C (co-corresponding author) and Li GH. “Recent advances in the study of testicular nuclear receptor 4” J Zhejiang Univ. Sci. B, 14(3): 171-7. (2013). PMID: 23463759. PMCID: PMC3596567
  9. Ma WL, Jeng LB, Yeh CC and Chang C “Androgen and androgen receptor signals jamming monocyte/macrophage functions in premalignant phase of livers” BioMedicine, xxx: 1-5.  (2012).
  10. Lai JJ, Chang P, Lai KP, Chen L and Chang C “The role of androgen and androgen receptor in skin-related disorders” Arch Dermatol. Res., 304(7), 499-510. (2012). PMID: 22829074
  11. Lin TH, Yeh S and Chang C “Tissue-specific knockout of androgen receptor in mice” Methods Mol. Biol., 776, 275-93. (2011). PMID: 21796532
  12. Niu Y, Chang TM, Yeh S, Ma WL, Wang YZ and Chang C "Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails" Oncogene 24:29(25), 3593-604 (2010). PMID: 20440270
  13. Wang RS, Yeh S, Tzeng CR, and Chang C “Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice” Endocrine Review, (2009): 30(2), 119-32. (2009). PMID: 19176467, PMCID PMC2662628
  14. Yu S, Lai KP, Xie S, Chang HC, Chang C (co-corresponding author) and Yeh S. “The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer” AJA, (2008): 11(1), 39-48, (2008). PMID: 19098932
  15. Ting HJ and Chang C “Actin Associated Proteins Function as Androgen Receptor Coregulators: An Implication of Androgen Receptor's Roles in Skeletal Muscle” JSBMB, 111(3-5), 157-63. (2008) PMID: 18590822
  16. Fujimoto N, Chang C, Nomura M and Matsumoto T "Can we prevent prostate cancer? Rationale and current status of prostate cancer chemoprevention." Urol. Int., 74(4), 289-97. (2005). PMID: 15897691
  17. Miyamoto H, Altuwaijri S, Cai Y, Messing E and Chang C "Inhibition of the Akt, cyclooxygenase-2, and MMP-9 pathways in combination with androgen deprivation therapy: Potential therapeutic approaches for prostate cancer." Mol. Carcinogen, 44(1): 1-10. (2005). PMID: 16044418           
  18. Miyamoto H, messing E and Chang C “Does androgen deprivation therapy improve treatment outcomes in patients with low- and intermediate-risk prostate cancer” Nature Clinical Practice: Oncology, 2: 236-7. (2005). PMID: 16264955
  19. Wang l, Hsu CL and Chang C “Androgen receptor co-repressors: an overview.” Prostate, 63(2), 117-30. (2005). PMID: 15486994
  20. Miyamoto H, Messing E and Chang C “Androgen Deprivation Therapy for Prostate Cancer: Current Status and       Future      Prospects.” Prostate, 61(4), 332-53. (2004). PMID: 15389811
  21. Heinlein CA and Chang C “Androgen receptor in prostate cancer.” Endocrine Reviews, 25, 276-308. (2004). PMID: 15082523
  22. Wang PH and Chang C "Androgens and ovarian cancers” Eur. J. Gynaec. Oncol., 25(2), 157-63. (2004). PMID: 15032272
  23. Miyamoto H, Rahman MM and Chang C “Molecular basis for the antiandrogen withdrawal syndrome” J. Cellular Biochemistry, 91(1), 3-12. (2004). PMID: 14689576
  24. Collins L, Lee H, Chen YT, Yeh S and Chang C "Androgen receptor in spermatogenesis.” Cytogenetic and Genome Research 103(3-4), 289-301. (2003). PMID: 15051951
  25. Lee DK and Chang C “Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication.” J. Clin. Endocrinol. Metab., 88, 4043-954. (2003). PMID: 12970260
  26. Kang HY, Tsai MY, Chang C and Huang KE “Mechanisms and clinical relevance of androgens and androgen receptor action.” Chang Gung Medical J., 26(6), 388-402. (2003). PMID: 12956285
  27. Lee H, and Chang C “Recent advances in the androgen receptor action.” Cellular and Molecular Life Sciences, 60(8), 1613-22. (2003). PMID: 14504652
  28. Lee DK and Chang C “Molecular communication between androgen receptor and general transcription machinery.” JSBMB, 84(1), 41-9. (2003). PMID: 12648523
  29. Heinlein CA, and Chang C “The roles of AR and androgen binding proteins in non-genomic androgen actions.” Mol. Endo., 16(10), 2181-7. (2002). PMID: 12351684
  30. Lee YF, Lee HJ and Chang C “Recent advances in the TR2 and TR4 orphan receptors of nuclear receptor superfamily.”  JSBMB, 81(4-5): 291-308. (2002). PMID: 12361719              
  31. Heinlein CA and Chang C “Androgen receptor co-regulator: an overview.” Endocrine Review, 23(2), 175-200. (2002). PMID: 11943742
  32. Sampson E, Yeh S, Chang H, Tsai M, Wang X, Ting H-J, and Chang C “Identification and characterization of androgen receptor associated co-regulators in prostate cancer cells.” J. Biological Regulation & Homeostatic Agents, 15(2): 123-9. (2001). PMID: 11501969      
  33. Heinlein CA and Chang C “The role of chaperones in the nuclear translocation and transactivation of steroid receptors.” Endocrine, 14(2), 143-9.(2001). PMID: 1139463
  34. Yeh S, Sampson E, Lee DK, Kim E, Hsu C, Chen Y, Chang HC, Altuwaijri S, Huang K, and Chang C “Functional analysis of N-terminal and Ligand-binding domain of androgen receptor co-activators in prostate cancer.” J. Formosan Medical Association, 99(12): 885-94. (2000). PMID: 11155740         
  35. Yeh S, Chang HC, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK and Chang C “Differential induction of androgen receptor transcriptional activity by selective androgen receptor co-activators.” Keio J. Medicine, 48(2): 87-92. (1999). PMID: 10405524
  36. Keller ET, Ershler WB, and Chang C “The androgen receptor: a mediator of diverse responses.” Frontiers in Bioscience, 1: d59-71.(1996).PMID: 9159212
  37. Chang C, Saltzman A, Yeh S, Young WJ, Keller E, Lee H-J, Wang C, and Mizokami A “Androgen receptors: an overview.” Critical Reviews in Eukaryotic Gene Expression, 5(2), 97-125.(1995). PMID: 8845584