| Steven Goldman, Chief, Division of Cell and Gene Therapy | |
| Senyo Agidi | Gang Lu, MD |
| Romane Auvergne, PhD | Crystal McClain |
| Janna Bates | Carolyn Moyle |
| Abdel Benraiss, PhD | Tricia Protack |
| Elodie Bruel-Jungerman, PhD | Neeta Roy, PhD (at Cornell Med. Ctr) |
| Jaclyn Burch | Fraser Sim, PhD |
| Devin Chandler-Militello | Steven Schanz |
| Zhuoxun Chen | Su Wang, MD, PhD |
| Barbara Germin, MD | Martha Windrem, MA |
| Min Guo, MD | Zheng-Hua Xie, PhD |
| Jennifer Lang | Alex Zielke |
| Ditte Lovatt | |
| Angela Warner |
Current Projects
- Human oligodendrocyte progenitor molecular biology
- Human neural stem cell and progenitor gene expression and differential signaling
- Tumor stem & progenitor cells of the human CNS
- Induced neurogenesis in neurodegenerative disease
- Progenitor cell-based myelination of congenitally dysmyelinated brain
- Relationship between angiogenesis and neurogenesis in the adult Canary
- Regulation of astrocytosis from endogenous progenitors
- Neural induction and therapeutic use of Human ES cells
Recent Lab Publications
Windrem MS, Schanz S, Guo M, Tian G, Washco V, Stanwood N, Rasband M, Roy NS, Medergaard N, Havton LA, Wang S, and Goldman SA (2008) Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell in press.
Kim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, Goldman SA. (2008) Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. J Neurosci. 28: 208-16.
Roy NS, Chandler-Militello D, Lu G, Wang S, Goldman SA. (2008) Retrovirally mediated telomerase immortalization of neural progenitor cells. Nat Protoc. 2: 2815-25.
Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. (2007) The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci. 27: 12255-66.
Goldman SA (2008) Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition. In: Adult Neurogenesis, F. Gage, G. Kemperman Eds. (Cold Spring Harbor Laboratory Press).
Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA. (2007) Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest. 117: 2889-902.
Goldman SA (2007) Disease Targets and Strategies for the Therapeutic Modulation of Endogenous Neural Stem and Progenitor Cells. Clin Pharmacol Ther. 2007 Aug 22
Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M (2007) Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med. 13: 477-85.
Keyoung HM, Goldman SA (2007) Glial progenitor-based repair of demyelinating neurological diseases. Neurosurg Clin N Am. 18:93-104.
Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M (2007) Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biol. 302:356-66.
Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA (2006) Neurocytoma is a tumor of adult neuronal progenitor cells. J Neurosci 26: 12544-12555.
Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA (2006) Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med. 2006 12:1259-68.
Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA (2006) Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol 59: 763-779.
Roy NS, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA (2005) Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 196:224-234.
Nakano T, Windrem MS, Zappavigna V, Goldman SA (2005) Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons. Dev Biol 283: 474-485.
Chmielnicki E, Benraiss A, Economides AN, Goldman SA (2004) Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J Neurosci 24: 2133-2142.