Steven A. Goldman, M.D., Ph.D.Chief, Division of Cell and Gene Therapy 585-275-9550 (phone)
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Recent Publications
Windrem MS, Schanz S, Guo M, Tian G, Washco V, Stanwood N, Rasband M, Roy NS, Medergaard N, Havton LA, Wang S, and Goldman SA (2008) Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell in press.
Kim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, Goldman SA. (2008) Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. J Neurosci. 28: 208-16.
Roy NS, Chandler-Militello D, Lu G, Wang S, Goldman SA. (2008) Retrovirally mediated telomerase immortalization of neural progenitor cells. Nat Protoc. 2: 2815-25.
Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. (2007) The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci. 27: 12255-66.
Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA. (2007) Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest. 117: 2889-902.
Goldman SA (2008) Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition. In: Adult Neurogenesis, F. Gage, G. Kemperman Eds. (Cold Spring Harbor Laboratory Press).
Goldman SA (2007) Disease Targets and Strategies for the Therapeutic Modulation of Endogenous Neural Stem and Progenitor Cells. Clin Pharmacol Ther. 2007 Aug 22
Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M (2007) Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med. 13: 477-85.
Keyoung HM, Goldman SA (2007) Glial progenitor-based repair of demyelinating neurological diseases. Neurosurg Clin N Am. 18:93-104.
Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M (2007) Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biol. 302:356-66.
Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA (2006) Neurocytoma is a tumor of adult neuronal progenitor cells. J Neurosci 26: 12544-12555.
Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA (2006) Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med. 2006 12:1259-68.
Goldman SA, Windrem MS (2006) Cell replacement therapy in neurological disease. Philos Trans R Soc Lond B Biol Sci. 29;361(1473):1463-75.
Goldman SA, Lang J, Roy N, Schanz SJ, Sim FS, Wang S, Washco V, Windrem MS. (2006) Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system. Ernst Schering Res Found Workshop. 60: 195-213.
Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA (2006) Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol 59: 763-779.
Sim FJ, Goldman SA (2005) White matter progenitor cells reside in an oligodendrogenic niche. Ernst Schering Res Found Workshop. 53: 61-81.
Roy NS, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA (2005) Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 196:224-234.
Nakano T, Windrem MS, Zappavigna V, Goldman SA (2005) Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons. Dev Biol 283: 474-485.
Goldman SA, Sim FJ (2005) Neural progenitor cells of the adult brain. Novartis Found Symp. 265: 66-80; discussion 82-97.
Chmielnicki E, Benraiss A, Economides AN, Goldman SA (2004) Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. J Neurosci 24: 2133-2142.
Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA (2004) Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol 22: 297-305.
Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 10: 821-827.
Windrem MS, Nunes MC, Rashbaum WK, Schwartz TH, Goodman RA, McKhann G, Roy NS, Goldman SA (2004) Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nat Med 10: 93-97.
Goldman S (2003) Glia as neural progenitor cells. Trends Neurosci 26: 590-596.
Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G, Jiang L, Kang J, Nedergaard M, Goldman SA (2003) Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 9: 439-447.
Packer MA, Stasiv Y, Benraiss A, Chmielnicki E, Grinberg A, Westphal H, Goldman SA, Enikolopov G (2003) Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A.
Chmielnicki E, Goldman SA (2002) Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain. Prog Brain Res 138: 451-464.
Louissaint A, Jr., Rao S, Leventhal C, Goldman SA (2002) Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34: 945-960.
Windrem MS, Roy NS, Wang J, Nunes M, Benraiss A, Goodman R, McKhann GM, Goldman SA (2002) Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J Neurosci Res 69: 966-975.
Benraiss A, Chmielnicki E, Lerner K, Roh D, Goldman SA (2001) Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J Neurosci 21: 6718-31.
Keyoung HM, Roy NS, Benraiss A, Louissaint A, Jr., Suzuki A, Hashimoto M, Rashbaum WK, Okano H, Goldman SA (2001) High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nat Biotechnol 19: 843-50.
Piper DR, Mujtaba T, Keyoung H, Roy NS, Goldman SA, Rao MS, Lucero MT (2001) Identification and characterization of neuronal precursors and their progeny from human fetal tissue. J Neurosci Res 66: 356-368.
Sawamoto K, Nakao N, Kakishita K, Ogawa Y, Toyama Y, Yamamoto A, Yamaguchi M, Mori K, Goldman SA, Itakura T, Okano H (2001) Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J Neurosci 21: 3895-903.
Grafstein B, Liu S, Cotrina ML, Goldman SA, Nedergaard M (2000) Meningeal cells can communicate with astrocytes by calcium signaling. Ann Neurol 47: 18-25.
Roy NS, Benraiss A, Wang S, Fraser RA, Goodman R, Couldwell WT, Nedergaard M, Kawaguchi A, Okano H, Goldman SA (2000) Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J Neurosci Res 59: 321-31.
Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA (2000) In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med 6: 271-277.
Wang S, Roy NS, Benraiss A, Goldman SA (2000) Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone. Dev Neurosci 22: 167-76.
Leventhal C, Rafii S, Rafii D, Shahar A, Goldman SA (1999) Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol Cell Neurosci 13: 450-64.
Roy NS, Wang S, Harrison-Restelli C, Benraiss A, Fraser RA, Gravel M, Braun PE, Goldman SA (1999) Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J Neurosci 19: 9986-95.
Williams S, Leventhal C, Lemmon V, Nedergaard M, Goldman SA (1999) Estrogen promotes the initial migration and inception of NgCAM- dependent calcium-signaling by new neurons of the adult songbird brain. Mol Cell Neurosci 13: 41-55.