Fraser J. Sim, Ph.D.Assistant Professor of Neurology and Neurosurgery 585-275-0987 (phone) |
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My main interests are in the molecular control of cell fate and homeostasis of resident progenitor cells in the adult human brain. Using genomics approaches we have begun to identify an array of signalling pathways which may operate in the regulation of glial progenitors. The functional significance of these pathways will be tested using pharmacolgical and lentiviral based overexpression and shRNAi in vitro and ultimately with in vivo models of CNS demyelination/remyelination.
Publications
Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. (2007) The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci. 27: 12255-66.
Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA (2006) Neurocytoma is a tumor of adult neuronal progenitor cells. J Neurosci 26: 12544-12555.
Goldman SA, Lang J, Roy N, Schanz SJ, Sim FJ, Wang S, Washco V, Windrem MS. (2006) Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system. Ernst Schering Res Found Workshop. 60: 195-213.
Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA (2006) Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol 59: 763-779.
Sim FJ, Goldman SA (2005) White matter progenitor cells reside in an oligodendrogenic niche. Ernst Schering Res Found Workshop. 53: 61-81.
Goldman SA, Sim FJ (2005) Neural progenitor cells of the adult brain. Novartis Found Symp. 265: 66-80; discussion 82-97.
Ibanez C, Shields SA, El Etr M, Leonelli E, Magnaghi V, Li WW, Sim FJ, Baulieu EE, Melcangi RC, Schumacher M, Franklin RJ (2003) Steroids and the reversal of age-associated changes in myelination and remyelination. Prog Neurobiol 71: 49-56.
Franklin RJ, Zhao C, Sim FJ (2002) Ageing and CNS remyelination. Neuroreport 13: 923-928.
Sim FJ, Zhao C, Li WW, Lakatos A, Franklin RJ (2002) Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. Mol Cell Neurosci 20: 669-682.
Sim FJ, Zhao C, Penderis J, Franklin RJ (2002) The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J Neurosci 22: 2451-2459.
Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001) Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35: 204-212.
Smith PM, Sim FJ, Barnett SC, Franklin RJ (2001) SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells. Glia 36: 342-353.
Sim FJ, Hinks GL, Franklin RJ (2000) The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain. Neuroscience 100: 131-139.