Health Research

Air Pollution Study for Older Adults (55-70 yrs)

Basic Study Information

How will inhaled ozone affect heart and blood vessel function of older adults during exercise?
We are looking for healthy volunteers 55-70 years old, getting regular exercise, with no smoking in the past 5 years, and no more than 10 years of past cigarette smoking. The main purpose of this study is to find out how inhaled ozone will affect heart and blood vessel function of healthy older adults during exercise. Understanding the effects of ozone on heart function, circulation and the airways can help set a safe air pollution standard for ozone and find ways to protect older people who may be at greatest risk. The first visit is the screening visit, which generally lasts about 3 hours. The next visit is the training visit, which is expected to last about 2 hours. If you qualify for the study after the screening visit and the training visit, you will be scheduled for three study periods. Each study period is spread over 3 days and includes an overnight stay at a hotel. We will ask you to wear a small personal exposure monitor for the 3 days before each study period. There will be at least 2 weeks in between each study period.

Lead Researcher (Principal Investigator)

Mark Frampton

Study Contact Information

Erika Little

Want to participate in this study as a healthy volunteer?

Your Information
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Are you 55-70 years old?

Do you get regular exercise?

Have you smoked in the past 5 years?

Have you smoked more than than 10 years in the past?

Have you used marijuana in the past 5 years?

Is your blood pressure greater than 140/90?

Do you use high blood pressure medication other than diuretics?

Do you have diabetes?

Do you have heart disease or any other organ dysfunction?

Do you have chronic respiratory disease or asthma?

Do you have an active psychiatric disorder?

Have you had a recent surgery?

Do you have a disease that affects the immune system (HIV, lymphoma, leukemia, etc)?

Do you have a job involving regular, heavy dust or particle exposure?

Do you have allergies that require frequent doctor visits, allergy shots, or regular treatment with antihistamines or systemic steroids?

Do you take Prednisone, Statins, Beta-blockers, Anticoagulants, Systemic Estrogen Therapy, Tamoxifen?

Are you willing to avoid ibuprofen, naproxen, aspirin, prednisone, antihistamines, over-the-counter decongestants, vitamins C and E, antioxidants, fish oil, niacin (vitamin B3), and arginine for 1 week before each 3-day study period?

Are you willing to avoid caffeine and minimize aerobic activity during each 3-day study period?



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Additional Study Information

More than Ten
Up to $2100 for completing entire study.

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