Email this pageEstimated Fees
It is critical for users to understand that we are not a screening service but rather are here to assist investigators to perform screening projects. All projects must have a dedicated individual postdoctoral fellow, technician or graduate student in the laboratory who will work closely with the director of the HTS facility to perform the screening project. All costs described below are to help support the basic functioning of the facility including library costs, equipment maintenance and personel.
Screening
A screening project consists generally consists of four phases.
- Assay development. In order to perform a screen an assay that is suitable for high throughput screening must be developed. Users must develop their own assays but must be realistic about what assays are suitable for HTS. The facility will provide advice on assay development and HTS facility equipment can be used to develop the assay. In the end the assay must be simple and robust. Time may have to be charged for working with the Facility Director to develop the assay.
More information: - Small scale Screen of Spectrum library. We recommend a 2000 molecule screen of the Spectrum library.
Pricing for this screen would be approximately $1000 - Large scale Screen of Chembridge library. 5000-20,000 compounds
Pricing for 20,000 compounds would be approximately $3000-$4000
Price includes cherry picking and hit validation in dose-response assays. - Chemi-informatics. The facility provides the computational capacity (Sybyl) to survey libraries for structural variants of initial hits for purchase and analysis.
Pricing ranges from $250-500
Equipment Rental
Equipment can also be used on a time basis for limited projects depending on availability with close supervision by the facility director.
Equipment |
Pricing/ hr |
|---|---|
Janus Robot |
$60.00 |
Envision Plate Reader |
$20.00 |
FlexDrop Liquid dispenser |
$20.00 |
Consumables and Reagents
Users will be responsible for the costs of consumables and reagents required to conduct the screen. Major consumable costs can include assay plates, pipette tips and assay reagents.
Service Request
Download and complete the request form. Once completed, return the form to Alan Smrcka.