Imaging Sciences (Radiology)

Publications

Recent Works

Tong Zhu, Xiaoxu Liu, John R Serafini; Patrick R Connelly, Jianhui Zhong. “Measurement Uncertainty of DTI Metrics in Human Brains (Part I): An Optimized Wild Bootstrap Method”. Submitted (2007).

Tong Zhu, Xiaoxu Liu, John R Serafini; Patrick R Connelly, Jianhui Zhong. “Measurement Uncertainty of DTI Metrics in Human Brains (Part II): Optimization of Clinical DTI Protocols with Wild Bootstrapping Analysis on Human Data”. Submitted (2007).

T. Gu, S. D. Kennedy, Z. Chen, J. Zhong. “Functional MRI at 3T using intermolecular double quantum coherence (iDQC) with spin-echo or gradient-echo acquisitions.” Submitted (2007)

Jeffrey J Bazarian, Jianhui Zhong, Brian Blyth, Tong Zhu, Voyko Kavcic, Derick Peterson, “Diffusion Tensor Imaging Detects Clinically Important Axonal Damage after Mild Traumatic Brain Injury.” In press, J. NeuroTrauma, (2007)

C. K. Wong, S.D. Kennedy, W. E Kwok, J Zhong. “Theoretical studies of iDQC signals in multiple spin-echo sequence with finite refocusing pulse duration.” J. Magn. Reson. 185:247–258 (2007)

Zhu XQ, Chen S, Chen Z, Cai SH, Zhong JH. Simultaneous acquisition and effective separation of different orders of intermolecular multiple-quantum signals. Chemical Physics Letters, 438:308–314 (2007)

Schifitto, G., Peterson, D.R., Zhong, J., Ni, H., Cruttenden, K., Gaugh, M., Gendelman, H.E., Boska, M. and H. Gelbard. “Valproic acid adjunctive therapy for HIV-associated cognitive impairment. A first report”. Neurology. 66(6):919-21 (2006)

Reports on Applications of fMRI in Tumors and Normal Brains

V. Kavcic, J. H. Zhong, T. Yoshiura, R.W. Doty. “Prefrontal cortex, laterality, and memory: encoding versus retrieval.” Acta Neurobiol Exp, 63:337-350, (2003)

D. Shibata, W.E. Kwok, J. H. Zhong, D. Shrier, Y. Numaguchi. "Functional MRI of vision in the deaf." 8:598-604. Acad. Radiol. (2001).

J. Zhong, W.E. Kwok, P. Okunieff. "FMRI for Monitoring Dynamic Changes in Brain Oxygenation / Blood Flow: Potential Application for Tumor Response to Carbogen Treatment," In press, Oxygen Transport to Tissue XXII, Proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissue. (Dunn, J.F. and H.M. Swartz eds), Pabst Science Publishers. Lengerich. (2000).

Hirotada Fujii, Xiaomin Wan, Jianhui Zhong, Lawence J. Berliner, and Kohki Yoshikawa, “In Vivo Imaging of Spin-Trapped Nitric Oxide in Rats With Septic Shock: MRI Spin Trapping”, Magn. Reson. Med. 42:235 (1999)

Takashi Yoshiura, Jianhui Zhong, Dean K. Shibata, Wingchi E. Kwok, David A. Shrier, Yuji Numaguchi, "Functional MRI Study of Auditory and Visual Oddball Tasks." NeuroReport, 10, 1683-1688 (1999).

Reports on MRI Techniques for Brain Diffusion Tensor Imaging (DTI)

Tong Zhu, Xiaoxu Liu, John R Serafini; Patrick R Connelly, Jianhui Zhong. “Measurement Uncertainty of DTI Metrics in Human Brains (Part I): An Optimized Wild Bootstrap Method”. Submitted (2007).

Tong Zhu, Xiaoxu Liu, John R Serafini; Patrick R Connelly, Jianhui Zhong. “Measurement Uncertainty of DTI Metrics in Human Brains (Part II): Optimization of Clinical DTI Protocols with Wild Bootstrapping Analysis on Human Data”. Submitted (2007).

Hongyan Ni, Voyko Kavcic, Tong Zhu, Sven Ekholm, Jianhui Zhong, “Effects of Number of Diffusion Gradient Directions on Derived DTI Indices in Human Brain.” Am J. Neuro Rad. AJNR 27:1776–81 (2006)

Akio Hiwatashi, Jianhui Zhong, Sven Ekholm, Per-Lennart Westesson. “Fractional Anisotropy was higher in Heschl's gyrus than in superior temporal gyrus in normal subjects.” Acad Radiol. 13(1):73-6 (2006)

J. H. Zhong, H. Ni, T. Zhu, S. Ekholm, V. Kavcic. “MR Diffusion Tensor Imaging (DTI) and Neuropsychological Testing for Neuronal Connectivity in Alzheimer’s Disease (AD) Patients.” Proceeding of SPIE Medical Imaging, 5369:238-249 (2004).

S. D. Kennedy, J. H. Zhong, “Diffusion measurements Free of Motion Artifacts Using Intermolecular Dopole-Dipole Interactions.” Magn. Reson. Med. 52:1-6 (2004)

Toshio Moritani, David A. Shrier, Yuji Numaguchi, Chihiro Takahashi, Takanori Yano, PhD, Kanji Nakai, Jianhui Zhong, Henry Z. Wang, Dean K. Shibata, Susan M. Naselli, “Diffusion-weighted Echo-planar MR Imaging of CNS Involvement in Systemic Lupus Erythematosus”. Acad. Radiol. 8:741-753 (2001)

G. Lin, Z. Chen, J. H. Zhong, D. Lin, X. Liao, “A novel propagator approach for NMR signal attenuation due to anisotropic diffusion under various magnetic field gradients”. Chem Phy. Lett. 335:249-256 (2001)

Chen Z, Kwok E, Zhong J. "Optimized gradient pulse design for fast diffusion-weighted MR imaging on a clinical Scanner." Radiology, 123(P):502 (1999).

List of Papers on Developing Intermolecular Multiple-quantum Coherences (iMQC) for New Applications in MRI

C. K. Wong, S.D. Kennedy, W. E Kwok, J. H. Zhong. “Theoretical studies of iDQC signals in multiple spin-echo sequence with finite refocusing pulse duration.” J. Magn. Reson. 185:247–258 (2007)

Zhu XQ, Chen S, Chen Z, Cai SH, Zhong JH. Simultaneous acquisition and effective separation of different orders of intermolecular multiple-quantum signals. Chemical Physics Letters, 438:308–314 (2007)

Xiaoqin Zhu, Zhong Chen, Shuhui Cai, Jianhui Zhong. “Formation and identification of pure intermolecular zero-quantum coherence signal in liquid NMR”. Chemical Physics Letters 421:171–178 (2006)

B. Zheng, Z. Chen, J. H. Zhong. “iDQC MRI Weighted by Longitudinal Relaxation in the Rotating Frame”. Mag. Reson. Med. 56:327-333(2006)

Z. Chen, X. Q. Zhu, B. W. Zheng, S. H. Cai, J. H. Zhong “Double-quantum-filtered intermolecular single-quantum coherences in nuclear magnetic resonance spectroscopy and imaging.” Chemical Physics Letter 429:611–616 (2006)

C. Cai, Z. Chen, S. Cai, J. Zhong. “A simulation algorithm based on Bloch equations and product operator matrix: application to dipolar and scalar couplings.” J. Magn. Reson. 172:242–253 (2005)

X. Q. Zhu, C. B. Cai, Z. Chen, J. Zhong. “Multiplet patterns of inter-molecular double quantum-coherences from dipolar and scalar couplings in solution nuclear magnetic resonance.” Chin Phys, 14:516-523 (2005).

B. Zheng, Z. Chen, S. Cai, J. Zhong, C. Ye. “Theoretical formalism and experimental verification of lineshapes of NMR intermolecular multiple-quantum coherences spectra.” J. Chem. Phys., 123:74317 (2005)

C. Cai, Z. Chen, S. Cai, X. Zhu, J. Zhong. “Finite difference simulation of diffusion behaviors under inter- and intra-molecular multiple-quantum coherences in liquid NMR”. Chem. Phys. Lett. 407:438-443 (2005).

C. Cai, Z. Chen, S. Cai, X. Zhu, J. Zhong. “Propagator formalism and computer simulation of restricted behavior of inter-molecular multiple-quantum coherences”. Physica B-Condensed Matter. 366:127-137 (2005).

X.Q. Zhu, Chen Z, Cai SH, Zhong JH. Selection of intra- or inter-molecular multiple-quantum coherences in NMR of highly polarized solution. Physica B, 362(1-4): 286-294 (2005).

X. Q. Zhu, Z. Chen, C. B. Cai, J. Zhong. “Selection of intra- or inter-molecular multiple-quantum-coherences in NMR of highly polarized solution.” Physica B, 286-294 (2005).

B. Zheng, Chen Z, Kennedy SK, Zhong J. “Investigation of Intermolecular Double-Quantum Off-resonance Longitudinal Relaxation in the Tilted Rotating Frame.” J. Chem. Phys. 123:74317 (2005)

C. Cai, S. Cai, Z. Chen, J. Zhong. “Numerical Simulations and Experimental Verification of High-Resolution NMR in Inhomogeneous Fields.” Submit to J. Magn. Reson. (2005)

T. Hou, Z. Chen, D.W. Hwang, J.H. Zhong and L.P. Hwang. “Intermolecular Double-Quantum Coherence MR Microimaging of Pig Tail with Unique Image Contrast.” Magn. Reson. Imaging 22:543-550 (2004)

J. Zhong, Z. Chen, S. D. Kennedy. “Properties and Applications of Intermolecular Dipole-Dipole Interactions in Biomedical NMR”. Recent Res. Devel. Chem. Phys. 5:23-55 (2004)

Z. Chen, ZW. Chen, J. Zhong, “High Resolution NMR Spectra in Inhomogeneous Fields via IDEAL (Intermolecular Dipolar interaction Enhanced All Lines) Method.” J. Am. Chem. Soc, 126:446-448 (2004)

S. D. Kennedy, J. Zhong, “Diffusion measurements Free of Motion Artifacts Using Intermolecular Dopole-Dipole Interactions.” Magn. Reson. Med. 52:1-6 (2004)

Z. Chen, Z-W Chen, D. W. Hwang, L-P Hwang. “Separation and characterization of different signals from intermolecular three-spin orders in solution NMR.” J. Magn. Reson, 171:244-252 (2004)

Q. L. Lin, S.H. Cai, Z. Chen, C.B. Cai. “Theoretical expression and computer simulation of diffusion behaviors in multiple-quantum coherence NMR.” Chin. J Chem Phys, 17:155-160 (2004).

X.Q. Zhu, S. Chen, Z. Chen , J. Zhong. “Intra- and inter-molecular multiple-quantum coherences in liquid nuclear magnetic resonance.” Recent Research Developments in Chemical Physics, 5:423-435 (2004).

J. Zhong, Z. Chen, E. Kwok, S. K. Kennedy, Z. G. You. “Optimization of BOLD sensitivity in MR imaging using intermolecular double-quantum coherence (iDQC)”. J. Magn. Reson. Med. 16:733-740 (2002)

Z. Chen, J. Zhong. “Observations and characterization of intermolecular homonuclear single-quantum coherences in liquid NMR.” J. Chem. Phys. 117:8426-35 (2002)

J. Zhong, Z. Chen, E. Kwok. “MR Imaging with Intermolecular Multiple-quantum Coherences (iMQCs): Fundamental Questions and Potentials”. BOPUXUE ZAZHI (Chinese Journal of Magnetic Resonance) 19:94-95 (2002)

J. Zhong, Z. Chen, E. Kwok, “fMRI of auditory stimulation with intermolecular double-quantum coherences at 1.5T.” Magn. Reson. Med. 45:356-364 (2001)

J. Zhong, Z. Chen, E. Kwok, “Enhanced sensitivity to molecular diffusion with intermolecular multiple-quantum coherences: implications and potential applications.” Magn. Reson. Imag. 19:33-39(2001)

Z. Chen, J. Zhong. “Unconventional diffusion behaviors of intermolecular multiple-quantum coherences in nuclear magnetic resonance”. J. Chem. Phys. 114:5642-53 (2001)

Z. Chen, Z.W. Chen, J. Zhong, “Quantitative characterization of intermolecular dipolar interactions of two-component systems in solution NMR." J. Chem Phys. 115:10769-79(2001)

Z. Chen, S. Zheng, J. Zhong, “Optimal RF flip angles for intermolecular multiple-quantum coherences of different orders with the CRAZED pulse sequence”. Chem Phy. Lett. 347:143-148 (2001)

J. Zhong, Z. Chen, E. Kwok, “In vivo intermolecular double-quantum imaging on a clinical 1.5T MR scanner.” Magn. Reson. Med. 43:335-341(2000)

J. Zhong, Z. Chen, E. wok, "New image contrast mechanisms in intermolecular double-quantum coherence human MR imaging." J. Magn. Reson. Imag 12:311-320 (2000).

Z. Chen, S.D. Kennedy, J. Zhong. "Quantitation of intermolecular dipolar effects in NMR spectroscopy and imaging based on demagnetizing field theory." Mag. Reson. Materials Phys. Bio. Med. 11:122-128 (2000)

Z. Chen, S. D. Kennedy, J. Zhong. “Theoretical and experimental confirmation of intermolecular dipolar effects under time-averaged magnetic filed gradients”, Chem. Phys. Lett., 313, 217 (1999)

Selected Previous Works

Torsten Rohlfing, Calvin R. Maurer, Jr., Walter G. O’Dell, Jianhui Zhong. “Modeling Liver Motion and Deformation During the Respiratory Cycle Using Intensity-Based Nonrigid Registration of Gated MR Images”. Med. Phys. 31:427-433 (2004)

WE. Kwok, SM. Totterman, J. H. Zhong, “Interleaved water and fat dual-echo spin echo imaging with intrinsic chemical-shift elimination”. J. Magn. Reson. Imag. 13:318-323 (2001)

Shuichi Higano, Jianhui Zhong, David A. Shrier, Dean K. Shibata, Yukinori Takase, Henry Wang, and Yuji Numaguchi. "Diffusion Anisotropy of the Internal Capsule and the Corona Radiata in Association with Stroke and Tumors as Measured by Diffusion-weighted MR Imaging". AJNR Am J Neuroradiol 22: 456-463 (2001).

W.E. Kwok, S.M. Totterman, J. H. Zhong. “Three-dimensional interleaved water and fat image acquisition with chemical-shift correction.” Magn. Reson. Med. 44, 322 (2000)

M. D. Does, J. Zhong, and J. C. Gore, "In-Vivo Measurement of ADC change due to Intravascular Susceptibility Variation," Magn. Reson. Med. 41, 236-240 (1999)

J. Zhong, R. P. Richard, R.K. Fulbright, J. C. Gore. "Quantitation of Intravascular and Extravascular Contributions to BOLD Effects Induced by Alteration in Oxygenation or Intravascular Contrast Agents." Magn. Reson. Med., 40, 526 (1998)

J-H. Gao, J. Zhong, and P. Fox, "Functional MRI", in Stroke: Pathophysiology, Diagnosis and Management, 3rd edition, edited by H.J.M. Barnett, J. P. Mohr, B. M. Stein and F. M. Yatsu, Churchill Livingstone International, 1998

J. Zhong, O.A.C. Petroff, J. C. Gore, J.W. Prichard. "Reversible, reproducible reduction of brain water apparent diffusion coefficient by cortical electroshocks," Magn. Reson. Med., 37,1, (1997)

A. W. Anderson, J. Zhong, O. A. C. Petroff, A. Szafer, B. R. Ransom, J. W. Prichard and J. C. Gore. "Effects of Osmotically Driven Cell Volume Changes on Diffusion Weighted Imaging of the Rat Optic Nerve," Magn. Reson. Med., 35:162-167 (1996)

R. P. Kennan, J. Zhong, and J. C. Gore. "Effects of magnetic susceptibility variations on the apparent diffusion measured by NMR," in Diffusion and Perfusion: Magnetic Resonance Imaging, edited by D. Le Bihan, Raven Press, (1995)

J. Zhong, O.A.C. Petroff, J.W. Prichard, and J.C. Gore. "Barbiturate-reversible reduction of water diffusion coefficient in flurothyl-induced status epilepticus in rats." Magn. Reson. Med. 33, 253 (1995)

A. Szafer, J. Zhong, and J.C. Gore, "Theoretical Model for Water Diffusion in Tissues", Magn. Reson. Med. 33, 697 (1995)

J.W. Prichard, J. Zhong, O. A. C. Petroff, and J. C. Gore. "Diffusion-Weighted NMR Imaging Changes Caused by Electrical Activation of the Brain." NMR in Biomed. 8, 359-364 (1995)

A. Szafer, J. Zhong, A. W. Anderson, J. C. Gore. "Diffusion-Weighted Imaging in Tissue: Theoretical Models." NMR Biomed., 8, 280 (1995)

R.P. Kennan, J. Gao, J. Zhong, and J.C. Gore. "A General Model of Microcirculatory Blood Flow Effects in Gradient Sensitized MRI." Med. Phys., 21, 539-545 (1994)

Ada Cheung, J. H. Zhong, J. C. Gore, and C. B. Cuono, "Localized in Vivo 31P NMR Spectroscopy of Skin Flap Metabolism", Magn. Reson. Med. 32, 572 (1994)

R.P Kennan, J. Gao, J. H. Zhong, and J.C. Gore, "A General Model of Microcirculatory Blood Flow Effects in Gradient Sensitized MRI", Med. Phys., 21, 539 (1994)

R. P. Kennan, J. H. Zhong, and J.C. Gore, "Susceptibility Contrast Mechanisms in Tissues", Magn. Reson. Med. 31, 9 (1994).

J. H. Zhong, R. P. Kennan, M. Schaub, and J.C. Gore, "Measurements of Transient Contrast Enhancement by Localized Water NMR Spectroscopy", J. Magn. Reson. Series B. 104, 111 (1994)

J. H. Zhong, O. A. C. Petroff, J. W. Prichard, and J. C. Gore, "Changes in Water Diffusion and Relaxation Properties of Rat Cerebrum During Status Epilepticus", Magn. Reson. Med. 30, 241, (1993)

J. H. Zhong and J.C. Gore, "Studies of Restricted Diffusion in Heterogeneous Media Containing Variations in Susceptibility", Magn. Reson. Med., 19, 276 (1991).

J. H. Zhong, R. P. Kennan, and J. C. Gore, "Effects of Susceptibility Variations on NMR Measurements of Diffusion", J. Magn. Reson., 95, 267 (1991).

R. P. Kennan, J. H. Zhong, and J.C. Gore, "On the Relative Importance of Paramagnetic Relaxation and Diffusion Mediated Susceptibility Losses in Tissues", Magn. Reson. Med., 22, 197 (1991)

J. H. Zhong, J.C. Gore and I.M. Armitage, "Quantitative Studies of Hydrodynamic Effects and Cross Relaxation in Protein Solutions and Tissues with Proton and Deuteron Longitudinal Relaxation Times", Magn. Reson. Med., 13, 192 (1990).

J. H. Zhong, J.C. Gore, and I.M. Armitage, "Relative Contributions of Chemical Exchange and Other Relaxation Mechanisms in Protein Solutions and Tissues", Magn. Reson. Med., 11, 295 (1989).

Contact

Jianhui Zhong
University of Rochester
601 Elmwood Ave.
Rochester, NY 14642