Principal Investigator

Robert A. Bambara, Ph.D. University of Rochester work 601 Elmwood Ave Rochester NY 14642 office: KMRB 2-9649 p (585) 275-3269

Research Projects

  • Human DNA Replication and Repair

    Human DNA Replication and Repair

    We are investigating regulation mechanisms of eukaryotic DNA replication and repair that have evolved to protect information in nuclear DNA. One strand of the DNA genome is made discontinuously, whereby Okazaki fragments about 150 nucleotides long are synthesized and joined.

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  • How HIV-1 Uses Its RNA Structure to Change Itself to Defeat Drug Therapy

    How HIV-1 Uses Its RNA Structure to Change Itself to Defeat Drug Therapy

    The goal of the overall project has been to understand the mechanism of strand transfer in HIV-1. Strand transfer is essential for viral replication and is the basis of recombination that creates viral diversity. Transfer involves a shift of the growing DNA primer from the original donor RNA template to a second acceptor RNA. More info...