Welcome to the Benoit Lab
Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design ‘smart’ materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
Current Research Projects
- Temporally Tunable, Enzymatically Responsive Delivery of Proangiogenic Peptides from Poly(ethylene glycol) Hydrogels.Adv Healthc Mater. (2015 Jul 07).
- Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model.Biomed Opt Express. 6, 2695-712. (2015 Jul 01).
- Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.Chem Commun (Camb). 51, 11260-3. (2015 Jun 30).