Welcome to the Benoit Lab
Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design ‘smart’ materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
Current Research Projects
- Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels. J Biomed Opt. 20, 051024. (2015 May 01).
- Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential: Winner of the Society for Biomaterials Student Award in the Undergraduate Category, Charlotte, NC, April 15 to 18, 2015. J Biomed Mater Res A. 103, 1291-302. (2015 Apr 01).
- pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence. ACS Nano. In press. (2015 Feb 13).