Welcome to the Benoit Lab
Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design ‘smart’ materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.
Current Research Projects
- Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.Chem Commun (Camb). 51, 11260-3. (2015 Jun 30).
- Emulating native periosteum cell population and subsequent paracrine factor production to promote tissue engineered periosteum-mediated allograft healing.Biomaterials. 52, 426-40. (2015 Jun 01).
- Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications.Tissue Eng Part A. 21, 1733-51. (2015 Jun 01).