Reactions that Lead to the Formation of Radicals that are Trapped in DNA
Radical trapping and reactions are being measured in a series of DNA crystals, testing our working model. Imbedded in the model are a number of specific hypotheses, such as:
- holes are initially trapped on sugar and guanine in a ratio of ˜1:3, and
- while most (~70%) of the electrons are initially trapped by reversible proton transfer to one-electron reduced cytosine, there is an important fraction (˜20%) that are trapped by irreversible proton transfer to the C5-C6 bond of reduced cytosine and thymine.