Principal Investigator

Edward Brown III , Ph.D. University of Rochester work Box 270168 601 Elmwood Ave Rochester NY 14642 office: MC 5-7224A p 585-273-5918 f 585-273-4746 Edward_Brown@urmc.rochester.edu

Recent Publications

The following list was auto-generated 3 days ago.

1. Perry SW
2. Burke RM
3. Brown EB
(2012 Jan 19). Two-Photon and Second Harmonic Microscopy in Clinical and Translational Cancer Research. Ann Biomed Eng. In press.
1. Bouta EM
2. Wood RW
3. Perry SW
4. Brown EB
5. Ritchlin CT
6. Xing L
7. Schwarz EM
(2011 Dec 01). Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes. Ann N Y Acad Sci. 1240, 47-52.
1. Madden KS
2. Szpunar MJ
3. Brown EB
(2011 Dec 01). β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines. Breast Cancer Res Treat. 130, 747-58.
1. Sullivan KD
2. Brown EB
(2011 May 01). Multiphoton fluorescence recovery after photobleaching in bounded systems. Phys Rev E Stat Nonlin Soft Matter Phys. 83, 051916.
1. Perry SW
2. Norman JP
3. Barbieri J
4. Brown EB
5. Gelbard HA
(2011 Feb 01). Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. Biotechniques. 50, 98-115.
1. Kozai TD
2. Marzullo TC
3. Hooi F
4. Langhals NB
5. Majewska AK
6. Brown EB
7. Kipke DR
(2010 Aug 01). Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping. J Neural Eng. 7, 046011.
1. Han X
2. Brown E
(2010 May 10). Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective. Opt Express. 18, 10538-50.
1. Li J
2. Sullivan K
3. Brown EB
4. Anthamatten M
(2010 Feb 08). Thermally activated diffusion in reversibly associating polymers. Soft Matter. 6, 235-238.
1. Sullivan KD
2. Brown EB
(2010 Jan 01). Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching. J Vis Exp. In press.
1. Chauhan VP
2. Lanning RM
3. Diop-Frimpong B
4. Mok W
5. Brown EB
6. Padera TP
7. Boucher Y
8. Jain RK
(2009 Jul 08). Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophys J. 97, 330-6.
1. Sullivan KD
2. Sipprell WH
3. Brown EB
4. Brown EB
(2009 Jun 17). Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo. Biophys J. 96, 5082-94.
1. Han X
2. Burke RM
3. Zettel ML
4. Tang P
5. Brown EB
(2008 Feb 04). Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma. Opt Express. 16, 1846-59.
1. Schmidt H
2. Arendt O
3. Brown EB
4. Schwaller B
5. Eilers J
(2007 Feb 01). Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones. J Neurochem. 100, 727-35.
1. Tyrrell JA
2. Mahadevan V
3. Tong RT
4. Brown EB
5. Jain RK
6. Roysam B
(2005 Nov 01). A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy. Microvasc Res. 70, 165-78.
1. Stroh M
2. Zimmer JP
3. Duda DG
4. Levchenko TS
5. Cohen KS
6. Brown EB
7. Scadden DT
8. Torchilin VP
9. Bawendi MG
10. Fukumura D
11. Jain RK
(2005 Jun 01). Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med. 11, 678-82.
1. Duda DG
2. Fukumura D
3. Munn LL
4. Booth MF
5. Brown EB
6. Huang P
7. Seed B
8. Jain RK
(2004 Sep 01). Differential transplantability of tumor-associated stromal cells. Cancer Res. 64, 5920-4.
1. Brown EB
2. Boucher Y
3. Nasser S
4. Jain RK
(2004 May 01). Measurement of macromolecular diffusion coefficients in human tumors. Microvasc Res. 67, 231-6.
1. Garkavtsev I
2. Kozin SV
3. Chernova O
4. Xu L
5. Winkler F
6. Brown E
7. Barnett GH
8. Jain RK
(2004 Mar 18). The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 428, 328-32.
1. Alexandrakis G
2. Brown EB
3. Tong RT
4. McKee TD
5. Campbell RB
6. Boucher Y
7. Jain RK
(2004 Feb 01). Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nat Med. 10, 203-7.
1. Znati CA
2. Rosenstein M
3. McKee TD
4. Brown E
5. Turner D
6. Bloomer WD
7. Watkins S
8. Jain RK
9. Boucher Y
(2003 Nov 15). Irradiation reduces interstitial fluid transport and increases the collagen content in tumors. Clin Cancer Res. 9, 5508-13.
1. Abdul-Karim MA
2. Al-Kofahi K
3. Brown EB
4. Jain RK
5. Roysam B
(2003 Sep 01). Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series. Microvasc Res. 66, 113-25.
1. Brown E
2. McKee T
3. diTomaso E
4. Pluen A
5. Seed B
6. Boucher Y
7. Jain RK
(2003 Jun 01). Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med. 9, 796-800.
1. Schmidt H
2. Brown EB
3. Schwaller B
4. Eilers J
(2003 Apr 01). Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching. Biophys J. 84, 2599-608.
1. Wei X
2. Henke VG
3. Strübing C
4. Brown EB
5. Clapham DE
(2003 Feb 01). Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J. 84, 1317-27.
1. Campbell RB
2. Fukumura D
3. Brown EB
4. Mazzola LM
5. Izumi Y
6. Jain RK
7. Torchilin VP
8. Munn LL
(2002 Dec 01). Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 62, 6831-6.
1. Migliorini C
2. Qian Y
3. Chen H
4. Brown EB
5. Jain RK
6. Munn LL
(2002 Oct 01). Red blood cells augment leukocyte rolling in a virtual blood vessel. Biophys J. 83, 1834-41.
1. Ramanujan S
2. Pluen A
3. McKee TD
4. Brown EB
5. Boucher Y
6. Jain RK
(2002 Sep 01). Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J. 83, 1650-60.
1. Padera TP
2. Kadambi A
3. di Tomaso E
4. Carreira CM
5. Brown EB
6. Boucher Y
7. Choi NC
8. Mathisen D
9. Wain J
10. Mark EJ
11. Munn LL
12. Jain RK
(2002 Jun 07). Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 296, 1883-6.
1. Brown EB
2. Campbell RB
3. Tsuzuki Y
4. Xu L
5. Carmeliet P
6. Fukumura D
7. Jain RK
(2001 Jul 01). In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med. 7, 864-8.
1. Pluen A
2. Boucher Y
3. Ramanujan S
4. McKee TD
5. Gohongi T
6. di Tomaso E
7. Brown EB
8. Izumi Y
9. Campbell RB
10. Berk DA
11. Jain RK
(2001 Apr 10). Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 98, 4628-33.
1. Majewska A
2. Brown E
3. Ross J
4. Yuste R
(2000 Mar 01). Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization. J Neurosci. 20, 1722-34.
1. Brown EB
2. Shear JB
3. Adams SR
4. Tsien RY
5. Webb WW
(1999 Jan 01). Photolysis of caged calcium in femtoliter volumes using two-photon excitation. Biophys J. 76, 489-99.
1. Brown EB
2. Webb WW
(1998 Jan 01). Two-photon activation of caged calcium with submicron, submillisecond resolution. Methods Enzymol. 291, 356-80.
1. Shear JB
2. Brown EB
3. Webb WW
(1996 May 15). Multiphoton-excited fluorescence of fluorogen-labeled neurotransmitters. Anal Chem. 68, 1778-83.