Principal Investigator

Mark Raymond Buckley, Ph.D. University of Rochester work Box 270168 Rochester NY 14627-0168 office: Goergen Hall 317 p (585) 276-4195

Contact

Buckley Lab University of Rochester work Goergen Hall 321 Rochester NY 14627-0168

Affiliations

The Buckley lab is currently accepting applications for graduate students interested in viscoelasticity in connective tissues. For more information, please contact Professor Buckley.

Viscoelasticity in Connective Tissues

Confocal micrograph of articular cartilage under dynamic shear loading. The black stripes are photobleached lines used as markers to track time-dependent tissue deformation.

Tendon, ligament, cartilage and many other soft biological tissues serve predominantly mechanical functions. However, unlike steel, concrete and other elastic solids, these structurally complex materials exhibit a history- and time-dependent response to loading (i.e., viscoelasticity) that must be characterized in order to predict in vivo deformations and understand loss of mechanical function in the pathological state. Our lab is interested in evaluating changes in soft tissue viscoelastic properties across multiple length scales during processes including exercise, aging, injury and disease and identifying the specific biological and structural factors responsible for these alterations. To characterize viscoelasticity at the tissue, matrix and cellular levels, we combine simultaneous high-speed microscopy, force measurement and control of deformation on live tissue explants. Using our findings, we seek to devise strategies for assessing the efficacy of treatments or diagnosing damage based on viscoelastic measurements.

Recent Publications

    1. Griffin DJ
    2. Vicari J
    3. Buckley MR
    4. Silverberg JL
    5. Cohen I
    6. Bonassar LJ
    (2014 Dec 01). Effects of enzymatic treatments on the depth-dependent viscoelastic shear properties of articular cartilage. J Orthop Res. 32, 1652-7.
    1. Perry JR
    2. Day F
    3. Elks CE
    4. Sulem P
    5. Thompson DJ
    6. Ferreira T
    7. He C
    8. Chasman DI
    9. Esko T
    10. Thorleifsson G
    11. Albrecht E
    12. Ang WQ
    13. Corre T
    14. Cousminer DL
    15. Feenstra B
    16. Franceschini N
    17. Ganna A
    18. Johnson AD
    19. Kjellqvist S
    20. Lunetta KL
    21. McMahon G
    22. Nolte IM
    23. Paternoster L
    24. Porcu E
    25. Smith AV
    26. Stolk L
    27. Teumer A
    28. Tšernikova N
    29. Tikkanen E
    30. Ulivi S
    31. Wagner EK
    32. Amin N
    33. Bierut LJ
    34. Byrne EM
    35. Hottenga JJ
    36. Koller DL
    37. Mangino M
    38. Pers TH
    39. Yerges-Armstrong LM
    40. Hua Zhao J
    41. Andrulis IL
    42. Anton-Culver H
    43. Atsma F
    44. Bandinelli S
    45. Beckmann MW
    46. Benitez J
    47. Blomqvist C
    48. Bojesen SE
    49. Bolla MK
    50. Bonanni B
    51. Brauch H
    52. Brenner H
    53. Buring JE
    54. Chang-Claude J
    55. Chanock S
    56. Chen J
    57. Chenevix-Trench G
    58. Collée JM
    59. Couch FJ
    60. Couper D
    61. Coviello AD
    62. Cox A
    63. Czene K
    64. D'adamo AP
    65. Davey Smith G
    66. De Vivo I
    67. Demerath EW
    68. Dennis J
    69. Devilee P
    70. Dieffenbach AK
    71. Dunning AM
    72. Eiriksdottir G
    73. Eriksson JG
    74. Fasching PA
    75. Ferrucci L
    76. Flesch-Janys D
    77. Flyger H
    78. Foroud T
    79. Franke L
    80. Garcia ME
    81. García-Closas M
    82. Geller F
    83. de Geus EE
    84. Giles GG
    85. Gudbjartsson DF
    86. Gudnason V
    87. Guénel P
    88. Guo S
    89. Hall P
    90. Hamann U
    91. Haring R
    92. Hartman CA
    93. Heath AC
    94. Hofman A
    95. Hooning MJ
    96. Hopper JL
    97. Hu FB
    98. Hunter DJ
    99. Karasik D
    100. Kiel DP
    101. Knight JA
    102. Kosma VM
    103. Kutalik Z
    104. Lai S
    105. Lambrechts D
    106. Lindblom A
    107. Mägi R
    108. Magnusson PK
    109. Mannermaa A
    110. Martin NG
    111. Masson G
    112. McArdle PF
    113. McArdle WL
    114. Melbye M
    115. Michailidou K
    116. Mihailov E
    117. Milani L
    118. Milne RL
    119. Nevanlinna H
    120. Neven P
    121. Nohr EA
    122. Oldehinkel AJ
    123. Oostra BA
    124. Palotie A
    125. Peacock M
    126. Pedersen NL
    127. Peterlongo P
    128. Peto J
    129. Pharoah PD
    130. Postma DS
    131. Pouta A
    132. Pylkäs K
    133. Radice P
    134. Ring S
    135. Rivadeneira F
    136. Robino A
    137. Rose LM
    138. Rudolph A
    139. Salomaa V
    140. Sanna S
    141. Schlessinger D
    142. Schmidt MK
    143. Southey MC
    144. Sovio U
    145. Stampfer MJ
    146. Stöckl D
    147. Storniolo AM
    148. Timpson NJ
    149. Tyrer J
    150. Visser JA
    151. Vollenweider P
    152. Völzke H
    153. Waeber G
    154. Waldenberger M
    155. Wallaschofski H
    156. Wang Q
    157. Willemsen G
    158. Winqvist R
    159. Wolffenbuttel BH
    160. Wright MJ
    161. Australian Ovarian Cancer Study
    162. GENICA Network
    163. kConFab
    164. LifeLines Cohort Study
    165. InterAct Consortium
    166. Early Growth Genetics (EGG) Consortium
    167. Boomsma DI
    168. Econs MJ
    169. Khaw KT
    170. Loos RJ
    171. McCarthy MI
    172. Montgomery GW
    173. Rice JP
    174. Streeten EA
    175. Thorsteinsdottir U
    176. van Duijn CM
    177. Alizadeh BZ
    178. Bergmann S
    179. Boerwinkle E
    180. Boyd HA
    181. Crisponi L
    182. Gasparini P
    183. Gieger C
    184. Harris TB
    185. Ingelsson E
    186. Järvelin MR
    187. Kraft P
    188. Lawlor D
    189. Metspalu A
    190. Pennell CE
    191. Ridker PM
    192. Snieder H
    193. Sørensen TI
    194. Spector TD
    195. Strachan DP
    196. Uitterlinden AG
    197. Wareham NJ
    198. Widen E
    199. Zygmunt M
    200. Murray A
    201. Easton DF
    202. Stefansson K
    203. Murabito JM
    204. Ong KK
    (2014 Oct 02). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature. 514, 92-7.
    1. Freedman BR
    2. Sarver JJ
    3. Buckley MR
    4. Voleti PB
    5. Soslowsky LJ
    (2014 Jun 27). Biomechanical and structural response of healing Achilles tendon to fatigue loading following acute injury. J Biomech. 47, 2028-34.