Viscoelasticity in Connective Tissues
Confocal micrograph of articular cartilage under dynamic shear loading. The black stripes are photobleached lines used as markers to track time-dependent tissue deformation.
Mechanics plays a key role in the onset, progression and treatment of several diseases that affect cartilage, tendon, cornea, sclera and other connective tissues. The Buckley lab is interested in evaluating pathology-associated mechanical changes in these tissues and using our findings to develop novel diagnostic tools and therapeutic strategies. We characterize the viscoelastic (i.e., rate- and time-dependent) mechanical response of connective tissues in vivo and in viable explants across multiple length scales using image-guided mechanical testing methods. Our current focus is on diseases of the musculoskeletal system (e.g., osteoarthritis and tendinopathy) and diseases of the eye (e.g., keratoconus and glaucoma) with significant public health impacts.
Current Research Projects
- Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage. J Orthop Res. In press. (2015 Mar 13).
- Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet. 47, 164-71. (2015 Feb 01).
- The location- and depth-dependent mechanical response of the human cornea under shear loading. Invest Ophthalmol Vis Sci. 55, 7919-24. (2014 Dec 01).