Principal Investigators

Charles J. Duffy, M.D., Ph.D. University of Rochester work Box 673 601 Elmwood Ave Rochester NY 14642 office: MC 6-8535 p 585-273-1696
William K. Page, Ph.D. University of Rochester work Box 673 601 Elmwood Ave Rochester NY 14642 office: MC 6-7530 p 585-273-2418

Research Projects

  • Encoding Path and Place

    Encoding Path and Place

    We recorded neuronal activity in monkey medial superior temporal (MST) cortex during movement on a motorized sled. Most neurons showed a preferred heading direction, but some responded only when that heading was part of a particular path. More info...

  • Influence of Attention on Neuronal Responses

    Influence of Attention on Neuronal Responses

    Optic flow selectively activates neurons in medial superior temporal (MST) cortex. We find that many MST neurons yield larger and more selective responses when the optic flow guides a subsequent eye movement. Smaller, less selective responses are seen when optic flow is preceded by a flashed precue that guides eye movements. More info...

  • Navigation in Alzheimer's Disease

    Navigation in Alzheimer's Disease

    Our findings in monkey cortical neurophysiology led us to consider the potential role of disordered optic flow analysis in human visuospatial disorientation. The visuospatial disorientation of Alzheimer's disease (AD) has several relevant features: patients get lost despite their recognizing landmarks, describing the route, recognizing familiar landmarks, and showing relative preservation of other capacities. More info...

  • Neuronal Integration of Visual Cues

    Neuronal Integration of Visual Cues

    Combined object motion and optic flow evoke a wide variety of response interactions with landmark and animate objects creating comparable effects. When baseline activity is subtracted, response interactions are distributed around simple additivity with a substantial number of sub-additive and super-additive responses. More info...

  • Neuronal Mechanisms of Distracted Driving

    Neuronal Mechanisms of Distracted Driving

    We presented naturalistic combinations of virtual self-movement stimuli while recording neuronal activity in monkey cerebral cortex. The monkeys used a joystick to steer their simulated heading direction guided by either object motion or optic flow. More info...

  • Optic Flow Evoked Potentials

    Optic Flow Evoked Potentials

    We developed an approach to using radial optic flow stimuli to elicit visual motion evoked potentials. Subjetcs view a random pattern of stationary dots and after a few hundred milliseconds, the dots move to create a radial pattern of optic flow. We record the responses to optic flow onset and compare the N200 response amplitudes across subject groups. More info...

  • Receptive Field Dynamics

    Receptive Field Dynamics

    Optic flow informs moving observers about their heading direction. Neurons in monkey medial superior temporal (MST) cortex show heading selective responses to optic flow and planar direction selective responses to patches of local motion. More info...

  • Sensory Interactions and Population Encoding

    Sensory Interactions and Population Encoding

    Dorsal medial superior temporal cortex (MSTd)’s population response encodes heading direction from optic flow seen during fixation or pursuit. Vestibular responses in these neurons might enhance heading representation during self-movement in light or provide an alternative basis for heading representation during self-movement in darkness. More info...