Signal Transduction; Membrane Protein Structure, Yeast Molecular Biology
Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.
- Identification of Destabilizing and Stabilizing Mutations of Ste2p, a G Protein-Coupled Receptor in Saccharomyces cerevisiae. Biochemistry. In press. (2015 Feb 24).
- Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors. Biochim Biophys Acta. 1838, 15-33. (2014 Jan 01).
- Guided reconstitution of membrane protein fragments. Biopolymers. 102, 16-29. (2014 Jan 01).