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Principal Investigator

Mark E. Dumont, Ph.D. University of Rochester work Box 712 601 Elmwood Ave Rochester NY 14642 office: MC 3-6536 p 585-275-2466 f 585-275-6007 Mark_Dumont@urmc.rochester.edu

Recent Publications

The following list was auto-generated 2 days ago.

• 1. Pryor EE
  2. Horanyi PS
  3. Clark KM
  4. Fedoriw N
  5. Connelly SM
  6. Koszelak-Rosenblum M
  7. Zhu G
  8. Malkowski MG
  9. Wiener MC
  10. Dumont ME
  (2013 Mar 29). Structure of the integral membrane protein CAAX protease Ste24p. Science. 339, 1600-4.
• 1. Pieper U
  2. Schlessinger A
  3. Kloppmann E
  4. Chang GA
  5. Chou JJ
  6. Dumont ME
  7. Fox BG
  8. Fromme P
  9. Hendrickson WA
  10. Malkowski MG
  11. Rees DC
  12. Stokes DL
  13. Stowell MH
  14. Wiener MC
  15. Rost B
  16. Stroud RM
  17. Stevens RC
  18. Sali A
  (2013 Feb 01). Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol. 20, 135-8.
• 1. Mathew E
  2. Ding FX
  3. Naider F
  4. Dumont ME
  (2013 Jan 01). Functional fusions of T4 lysozyme in the third intracellular loop of a G protein-coupled receptor identified by a random screening approach in yeast. Protein Eng Des Sel. 26, 59-71.
• 1. Gehret AU
  2. Connelly SM
  3. Dumont ME
  (2012 Oct 01). Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors. Eukaryot Cell. 11, 1276-88.
• 1. Lesoine JF
  2. Venkataraman PA
  3. Maloney PC
  4. Dumont ME
  5. Novotny L
  (2012 Jun 13). Nanochannel-based single molecule recycling. Nano Lett. 12, 3273-8.
• 1. Taslimi A
  2. Mathew E
  3. Celić A
  4. Wessel S
  5. Dumont ME
  (2012 May 18). Identifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2p. J Mol Biol. 418, 367-78.
• 1. Kang DC
  2. Venkataraman PA
  3. Dumont ME
  4. Maloney PC
  (2011 Oct 04). Oligomeric state of the oxalate transporter, OxlT. Biochemistry. 50, 8445-53.
• 1. Mathew E
  2. Bajaj A
  3. Connelly SM
  4. Sargsyan H
  5. Ding FX
  6. Hajduczok AG
  7. Naider F
  8. Dumont ME
  (2011 Jun 17). Differential interactions of fluorescent agonists and antagonists with the yeast G protein coupled receptor Ste2p. J Mol Biol. 409, 513-28.
• 1. Clark KM
  2. Fedoriw N
  3. Robinson K
  4. Connelly SM
  5. Randles J
  6. Malkowski MG
  7. DeTitta GT
  8. Dumont ME
  (2010 Jun 01). Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography. Protein Expr Purif. 71, 207-23.
• 1. Shi S
  2. Notenboom S
  3. Dumont ME
  4. Ballatori N
  (2010 Jan 01). Identification of human gene products containing Pro-Pro-x-Tyr (PY) motifs that enhance glutathione and endocytotic marker uptake in yeast. Cell Physiol Biochem. 25, 293-306.
• 1. Chloupková M
  2. Pickert A
  3. Lee JY
  4. Souza S
  5. Trinh YT
  6. Connelly SM
  7. Dumont ME
  8. Dean M
  9. Urbatsch IL
  (2007 Jul 10). Expression of 25 human ABC transporters in the yeast Pichia pastoris and characterization of the purified ABCC3 ATPase activity. Biochemistry. 46, 7992-8003.
• 1. Bajaj A
  2. Connelly SM
  3. Gehret AU
  4. Naider F
  5. Dumont ME
  (2007 Jun 01). Role of extracellular charged amino acids in the yeast alpha-factor receptor. Biochim Biophys Acta. 1773, 707-17.
• 1. White MA
  2. Clark KM
  3. Grayhack EJ
  4. Dumont ME
  (2007 Jan 19). Characteristics affecting expression and solubilization of yeast membrane proteins. J Mol Biol. 365, 621-36.
• 1. Wang Z
  2. Stalcup LD
  3. Harvey BJ
  4. Weber J
  5. Chloupkova M
  6. Dumont ME
  7. Dean M
  8. Urbatsch IL
  (2006 Aug 15). Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8. Biochemistry. 45, 9929-39.
• 1. Gehret AU
  2. Bajaj A
  3. Naider F
  4. Dumont ME
  (2006 Jul 28). Oligomerization of the yeast alpha-factor receptor: implications for dominant negative effects of mutant receptors. J Biol Chem. 281, 20698-714.
• 1. Gelperin DM
  2. White MA
  3. Wilkinson ML
  4. Kon Y
  5. Kung LA
  6. Wise KJ
  7. Lopez-Hoyo N
  8. Jiang L
  9. Piccirillo S
  10. Yu H
  11. Gerstein M
  12. Dumont ME
  13. Phizicky EM
  14. Snyder M
  15. Grayhack EJ
  (2005 Dec 01). Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev. 19, 2816-26.
• 1. Bajaj A
  2. Celić A
  3. Ding FX
  4. Naider F
  5. Becker JM
  6. Dumont ME
  (2004 Oct 26). A fluorescent alpha-factor analogue exhibits multiple steps on binding to its G protein coupled receptor in yeast. Biochemistry. 43, 13564-78.
• 1. Alexandrov A
  2. Vignali M
  3. LaCount DJ
  4. Quartley E
  5. de Vries C
  6. De Rosa D
  7. Babulski J
  8. Mitchell SF
  9. Schoenfeld LW
  10. Fields S
  11. Hol WG
  12. Dumont ME
  13. Phizicky EM
  14. Grayhack EJ
  (2004 Sep 01). A facile method for high-throughput co-expression of protein pairs. Mol Cell Proteomics. 3, 934-8.
• 1. Roginskaya M
  2. Connelly SM
  3. Kim KS
  4. Patel D
  5. Dumont ME
  (2004 Mar 01). Effects of mutations in the N terminal region of the yeast G protein alpha-subunit Gpa1p on signaling by pheromone receptors. Mol Genet Genomics. 271, 237-48.
• 1. Celić A
  2. Connelly SM
  3. Martin NP
  4. Dumont ME
  (2004 Jan 01). Intensive mutational analysis of G protein-coupled receptors in yeast. Methods Mol Biol. 237, 105-20.
• 1. Celić A
  2. Martin NP
  3. Son CD
  4. Becker JM
  5. Naider F
  6. Dumont ME
  (2003 Mar 18). Sequences in the intracellular loops of the yeast pheromone receptor Ste2p required for G protein activation. Biochemistry. 42, 3004-17.
• 1. Martin NP
  2. Celić A
  3. Dumont ME
  (2002 Apr 12). Mutagenic mapping of helical structures in the transmembrane segments of the yeast alpha-factor receptor. J Mol Biol. 317, 765-88.
• 1. Erlenbach I
  2. Kostenis E
  3. Schmidt C
  4. Serradeil-Le Gal C
  5. Raufaste D
  6. Dumont ME
  7. Pausch MH
  8. Wess J
  (2001 Aug 03). Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis. J Biol Chem. 276, 29382-92.
• 1. Sommers CM
  2. Martin NP
  3. Akal-Strader A
  4. Becker JM
  5. Naider F
  6. Dumont ME
  (2000 Jun 13). A limited spectrum of mutations causes constitutive activation of the yeast alpha-factor receptor. Biochemistry. 39, 6898-909.
• 1. Leavitt LM
  2. Macaluso CR
  3. Kim KS
  4. Martin NP
  5. Dumont ME
  (1999 Jul 01). Dominant negative mutations in the alpha-factor receptor, a G protein-coupled receptor encoded by the STE2 gene of the yeast Saccharomyces cerevisiae. Mol Gen Genet. 261, 917-32.
• 1. Martin NP
  2. Leavitt LM
  3. Sommers CM
  4. Dumont ME
  (1999 Jan 12). Assembly of G protein-coupled receptors from fragments: identification of functional receptors with discontinuities in each of the loops connecting transmembrane segments. Biochemistry. 38, 682-95.
• 1. Rebbeor JF
  2. Connolly GC
  3. Dumont ME
  4. Ballatori N
  (1998 Dec 11). ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins. J Biol Chem. 273, 33449-54.
• 1. Rebbeor JF
  2. Connolly GC
  3. Dumont ME
  4. Ballatori N
  (1998 Sep 15). ATP-dependent transport of reduced glutathione in yeast secretory vesicles. Biochem J. 334 ( Pt 3), 723-9.
• 1. Pollock WB
  2. Rosell FI
  3. Twitchett MB
  4. Dumont ME
  5. Mauk AG
  (1998 Apr 28). Bacterial expression of a mitochondrial cytochrome c. Trimethylation of lys72 in yeast iso-1-cytochrome c and the alkaline conformational transition. Biochemistry. 37, 6124-31.
• 1. Sommers CM
  2. Dumont ME
  (1997 Feb 28). Genetic interactions among the transmembrane segments of the G protein coupled receptor encoded by the yeast STE2 gene. J Mol Biol. 266, 559-75.
• 1. Wang X
  2. Dumont ME
  3. Sherman F
  (1996 Mar 22). Sequence requirements for mitochondrial import of yeast cytochrome c. J Biol Chem. 271, 6594-604.
• 1. Dumont ME
  2. Corin AF
  3. Campbell GA
  (1994 Jun 14). Noncovalent binding of heme induces a compact apocytochrome c structure. Biochemistry. 33, 7368-78.
• 1. Dumont ME
  2. Schlichter JB
  3. Cardillo TS
  4. Hayes MK
  5. Bethlendy G
  6. Sherman F
  (1993 Oct 01). CYC2 encodes a factor involved in mitochondrial import of yeast cytochrome c. Mol Cell Biol. 13, 6442-51.
• 1. Dumont ME
  2. Cardillo TS
  3. Hayes MK
  4. Sherman F
  (1991 Nov 01). Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol. 11, 5487-96.
• 1. Dumont ME
  2. Sherman F
  3. Thomas DY
  (1989 Jan 01). Protein targeting and protein secretion. Genome. 31, 1109-10.
• 1. Dumont ME
  2. Ernst JF
  3. Sherman F
  (1988 Nov 05). Coupling of heme attachment to import of cytochrome c into yeast mitochondria. Studies with heme lyase-deficient mitochondria and altered apocytochromes c. J Biol Chem. 263, 15928-37.
• 1. Dumont ME
  2. Richards FM
  (1988 Feb 05). The pH-dependent conformational change of diphtheria toxin. J Biol Chem. 263, 2087-97.
• 1. Dumont ME
  2. Dei-Cas E
  3. Maurois P
  4. Slomianny C
  5. Prensier G
  6. Houcke-Lecomte M
  7. Vernes A
  8. Camus D
  (1988 Jan 01). [Histopathology of the liver and kidney during malaria: relation to malaria-induced dyslipoproteinemia]. Ann Parasitol Hum Comp. 63, 171-83.
• 1. Dumont ME
  2. Ernst JF
  3. Hampsey DM
  4. Sherman F
  (1987 Jan 01). Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. EMBO J. 6, 235-41.
• 1. Dumont ME
  2. Trewhella J
  3. Engelman DM
  4. Richards FM
  (1985 Jan 01). Stability of transmembrane regions in bacteriorhodopsin studied by progressive proteolysis. J Membr Biol. 88, 233-47.
• 1. Dumont ME
  2. Richards FM
  (1984 Apr 10). Insertion of apocytochrome c into lipid vesicles. J Biol Chem. 259, 4147-56.