Honors & News
April 15, 2015
Elliott Lab Awarded Grant To Study The Role Of Efferocytosis In Resolving Inflammation
The transition of the immune response from inflammation to resolution is critical for the restoration of tissue function following injury or infection. Most inflamed tissues contain large numbers of dead and dying cells, and the phagocytic clearance of these cells (a process termed "efferocytosis") by tissue-resident macrophages plays an important but poorly understood role in driving pro-resolution immune responses. CD73, the main adenosine-generating ecto-enzyme on leukocytes, exerts a wide range of immunomodulatory effects, but its role in efferocytosis is not known. The laboratory of Michael R. Elliott has been awarded a five-year grant from the National Institutes of Health to study the molecular mechanisms and physiologic importance of the CD73 pathway in mediating efferocytosis-dependent immune suppression in inflamed tissues (R01AI114554). Identifying the molecular pathways that link cell clearance to inflammation could contribute to the development of novel therapeutic strategies to affect beneficial immune responses in a wide range of inflammation-related disorders.
February 6, 2015
Taylor Moon Appointed to Position on the HIV Replication and Pathogenesis Traning Grant
May 13, 2014
Patrick Murphy Receives Trainee Abstract Award at 2014 AAI Meeting
Graduate student, Patrick Murphy received the Trainee Abstract Award at the 2014 AAI Immunology Conference for his work,
Apoptotic cells suppress TNF production by tissue resident macrophages through a CD73-dependent mechanism.
Patrick is currently working on Purinergic regulation of macrophage inflammatory responses in Dr. Rusty Elliott's lab. The Elliott lab is focused on understanding the signaling pathways that regulate how phagocytes locate and engulf apoptotic cells and how this process impacts the immune system in normal and disease states.
October 21, 2013
CVBI Students Receive Young Investigator Award at NYIC
The Kim lab Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research, and the Elliott lab understand the signaling pathways that regulate how phagocytes locate and engulf apoptotic cells and how this process impacts the immune system in normal and disease states.
August 15, 2013
Tara Capece and Patrick Murphy Appointed to Immunology Training Grant
December 7, 2012
Michael R. Elliott, Ph.D. was recently announced as a recipient of a Creative and Novel Ideas in HIV Research (CNIHR) research grant at the XIX International AIDS Conference in Washington D.C. The CNIHR program is jointly sponsored by the National Institutes of Health (NIH), the NIH-supported Centers for AIDS Research (CFARs) and the International AIDS Society (IAS) with the aim to promote innovative research and novel ideas from early stage investigators whose primary focus has previously been in fields of scientific inquiry other than HIV. Dr. Elliott will work with Stephen Dewhurst, Ph.D. to complete a research project, entitled
Apoptotic cell clearance signaling and HIV-associated inflammation.An interview with Dr. Elliott describing this project can be viewed below:
- Essential role of Elmo1 in Dock2-dependent lymphocyte migration.J Immunol. 192, 6062-70. (2014 Jun 15).
- Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein.Nature. 477, 220-4. (2011 Sep 08).