Cells undergoing apoptosis can release soluble cues (
find-mesignals) that promote the recruitment of phagocytes in the initial stages of apoptotic cell clearance. Triphosphate nucleotides (ATP and UTP), acting via P2Y receptors on phagocytes, were recently identified as such a
find-mecue. More info...
Mammalian ELMO proteins (ELMO1-3, Engulfment and Motility) are a family of evolutionarily conserved cytoplasmic adaptor proteins that function in concert with Dock proteins to promote the activation of the small GTPase Rac, a critical regulator of actin polymerization, cell shape and motility. More info...