Principal Investigator

Michael R. Elliott, Ph.D. University of Rochester work Box 609 601 Elmwood Ave Rochester NY 14642 office: KMRB 3-9625 p (585) 273-4793

Research Projects

  • Role of Find-Me Signals in Cell Clearance and Immunity

    Role of Find-Me Signals in Cell Clearance and Immunity

    Cells undergoing apoptosis can release soluble cues (find-me signals) that promote the recruitment of phagocytes in the initial stages of apoptotic cell clearance. Triphosphate nucleotides (ATP and UTP), acting via P2Y receptors on phagocytes, were recently identified as such a find-me cue. More info...

  • Regulation of leukocyte motility by ELMO family proteins

    Regulation of leukocyte motility by ELMO family proteins

    Mammalian ELMO proteins (ELMO1-3, Engulfment and Motility) are a family of evolutionarily conserved cytoplasmic adaptor proteins that function in concert with Dock proteins to promote the activation of the small GTPase Rac, a critical regulator of actin polymerization, cell shape and motility. More info...