Honors & News
February 16, 2012
Scientists have taken a remarkably detailed look at the initial steps that occur in the body when type 1 diabetes mellitus first develops in a child or young adult. The analysis comes from a team of researchers and physicians at the University of Rochester Medical Center who have expertise both in the laboratory and in treating patients. The team studied children from ages 8 to 18 within 48 hours of their diagnosis with type 1 diabetes, an autoimmune disease where the body's immune system attacks the cells in the pancreas that make insulin.
The trend is noticeable to pediatrician Nicholas Jospe, M.D., chief of Pediatric Endocrinology at Golisano Children's Hospital of the University of Rochester Medical Center, and his colleagues nationwide. His group now sees about 90 new cases of type 1 diabetes per year, compared to approximately 25 annually 20 years ago.
Every day, at the eastern end of the medical center, Jospe counsels families and children coping with the condition. At the same time, in a labyrinth of laboratories situated nearly half a mile to the west under the same roof, immunologists like Deborah J. Fowell, Ph.D., use an array of high-tech equipment to interrogate the likes of T-cells and macrophages for answers about the workings of the immune system.
May 11, 2009
Earlier this month, the University of Rochester Medical Center again became one of only nine institutions nationwide to receive a new wave of National Institutes of Health dollars designed to pave inroads into unraveling – and treating – autoimmune diseases.
In 2003, a similar endeavor to establish nine
Autoimmunity Centers of Excellence(or ACEs) – which would supercharge research into conditions like lupus, diabetes (type 1), multiple sclerosis and some types of arthritis – also targeted URMC. Together with Duke University and the University of California, San Francisco, Rochester's is among only three of the original ACEs to be refunded, receiving at least $5 million over the next five years, and possibly more if supplementary money is awarded for additional trials.
Historically, URMC has been a powerful player in the field of immunology, with researchers knee-deep in deciphering the inner workings of the immune system, and in hot pursuit of new ways to manufacture vaccines. But according to Ignacio Sanz, M.D., chief of the division of Allergy/Immunology & Rheumatology at URMC, and also principal investigator for URMC's ACE, it's also possible the broad-reaching nature of the proposed projects was a key factor in the Rochester center's renewal.
Our studies will focus on fundamental questions – namely, how immune cells, like B and T cells, are mis-regulated, confusing the body into attacking its own tissues,Sanz said.
What we learn is likely to illuminate research across the whole spectrum of similar diseases.
February 6, 2009
Bolstered by a five-year, $1.9 million research grant from the National Institutes of Health, Jennifer Anolik, M.D., Ph.D., assistant professor of Medicine and of Pathology and Laboratory Medicine, plans to probe why certain targeted therapies prove effective for some lupus patients, but not others.
Working with Anolik on the study are Jane Liesveld, M.D., professor of Medicine and professor at the James P. Wilmot Cancer Center; Deborah Fowell, Ph.D., associate professor of Microbiology and Immunology; and Frances Lund, Ph.D., professor of Medicine in the Division of Allergy/Immunology and Rheumatology.
- Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med. 209, 1349-62. (2012 Jul 02).
- Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells. J Immunol. 188, 947-51. (2012 Feb 01).