Principal Investigator

Thomas A. Gasiewicz, Ph.D. University of Rochester work Box EHSC 601 Elmwood Ave Rochester NY 14642 office: MC 4-5702 p 585-275-7723

Research Projects

The laboratory has two primary areas of ongoing research, both of which focus on the aryl hydrocarbon receptor’s role in human disease. The AhR receptor belongs to a family of transcription factors that are involved in regulating tissue development and cellular differentiation. While the true physiological function of the AhR receptor is not known, activation of AhR by environmental toxins such as dioxins and polycyclic aromatic hydrocarbons (PAH) leads to several adverse effects in humans including cancer.

  • Role of AhR in Hematopoiesis and Hematopoietic Disease

    Role of AhR in Hematopoiesis and Hematopoietic Disease

    Our laboratory has demonstrated that persistent activation of AhR by dioxin results in altered numbers and functions of hematopoietic stem cells (HSCs) in mouse bone marrow. Combined with data showing that a lack of AhR function also results in altered HSC characteristics and hematopoietic diseases (such as leukemia), our findings strongly suggest that a normal role for AhR may be to regulate HSC’s. The lab is currently studying this connection as well as how changing AhR regulation and function leads to hematopoietic diseases. More info...

  • Interactions of EGCG and Hsp90 in Oncogenesis

    Interactions of EGCG and Hsp90 in Oncogenesis

    Several epidemiological studies and clinical trials have shown the effectiveness of green tea (GT) extract for the prevention of UV-induced skin injuries, oxidative DNA damage, as well as prostate cancer. Epigallocatechin-3-gallate (EGCG), a major antioxidant in GT, has been suggested to target several biomedically relevant molecules and disease-related cellular processes. However, the precise molecular and cellular mechanisms by which EGCG acts to modulate tumor growth have yet to be determined. More info...