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Principal Investigator

Fred Hagen, Ph.D. University of Rochester work Box 712 601 Elmwood Ave Rochester NY 14642 office: KMRB G-9828 p 585-275-0336 f 585-276-0190 fred_hagen@urmc.rochester.edu

Recent Publications

The following list was auto-generated 1 week ago.

• 1. Miralem T
  2. Lerner-Marmarosh N
  3. Gibbs PE
  4. Tudor C
  5. Hagen FK
  6. Maines MD
  (2012 Jul 13). The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cδ activity: the peptides are inhibitors or substrate for the protein kinase C. J Biol Chem. 287, 24698-712.
• 1. Wangler NJ
  2. Santos KL
  3. Schadock I
  4. Hagen FK
  5. Escher E
  6. Bader M
  7. Speth RC
  8. Karamyan VT
  (2012 Jan 02). Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site. J Biol Chem. 287, 114-22.
• 1. Hagen FK
  (2012 Jan 01). Proteoglycan: site mapping and site-directed mutagenesis. Methods Mol Biol. 836, 23-34.
• 1. Marimuthu S
  2. Chivukula RS
  3. Alfonso LF
  4. Moridani M
  5. Hagen FK
  6. Bhat GJ
  (2011 Nov 01). Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets. Int J Oncol. 39, 1273-83.
• 1. Griffiths AE
  2. Wang W
  3. Hagen FK
  4. Fay PJ
  (2011 Aug 01). Use of affinity-directed liquid chromatography-mass spectrometry to map the epitopes of a factor VIII inhibitor antibody fraction. J Thromb Haemost. 9, 1534-40.
• 1. Nasim S
  2. Pei S
  3. Hagen FK
  4. Jordan CT
  5. Crooks PA
  (2011 Feb 15). Melampomagnolide B: a new antileukemic sesquiterpene. Bioorg Med Chem. 19, 1515-9.
• 1. Ambatipudi KS
  2. Hagen FK
  3. Delahunty CM
  4. Han X
  5. Shafi R
  6. Hryhorenko J
  7. Gregoire S
  8. Marquis RE
  9. Melvin JE
  10. Koo H
  11. Yates JR
  (2010 Dec 03). Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface. J Proteome Res. 9, 6605-14.
• 1. Ambatipudi KS
  2. Lu B
  3. Hagen FK
  4. Melvin JE
  5. Yates JR
  (2009 Nov 01). Quantitative analysis of age specific variation in the abundance of human female parotid salivary proteins. J Proteome Res. 8, 5093-102.
• 1. Gonzalez-Begne M
  2. Lu B
  3. Han X
  4. Hagen FK
  5. Hand AR
  6. Melvin JE
  7. Yates JR
  (2009 Mar 01). Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res. 8, 1304-14.
• 1. Denny P
  2. Hagen FK
  3. Hardt M
  4. Liao L
  5. Yan W
  6. Arellanno M
  7. Bassilian S
  8. Bedi GS
  9. Boontheung P
  10. Cociorva D
  11. Delahunty CM
  12. Denny T
  13. Dunsmore J
  14. Faull KF
  15. Gilligan J
  16. Gonzalez-Begne M
  17. Halgand F
  18. Hall SC
  19. Han X
  20. Henson B
  21. Hewel J
  22. Hu S
  23. Jeffrey S
  24. Jiang J
  25. Loo JA
  26. Ogorzalek Loo RR
  27. Malamud D
  28. Melvin JE
  29. Miroshnychenko O
  30. Navazesh M
  31. Niles R
  32. Park SK
  33. Prakobphol A
  34. Ramachandran P
  35. Richert M
  36. Robinson S
  37. Sondej M
  38. Souda P
  39. Sullivan MA
  40. Takashima J
  41. Than S
  42. Wang J
  43. Whitelegge JP
  44. Witkowska HE
  45. Wolinsky L
  46. Xie Y
  47. Xu T
  48. Yu W
  49. Ytterberg J
  50. Wong DT
  51. Yates JR
  52. Fisher SJ
  (2008 May 01). The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 7, 1994-2006.
• 1. Tenno M
  2. Ohtsubo K
  3. Hagen FK
  4. Ditto D
  5. Zarbock A
  6. Schaerli P
  7. von Andrian UH
  8. Ley K
  9. Le D
  10. Tabak LA
  11. Marth JD
  (2007 Dec 01). Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol. 27, 8783-96.
• 1. Wang H
  2. Julenius K
  3. Hryhorenko J
  4. Hagen FK
  (2007 May 11). Systematic Analysis of proteoglycan modification sites in Caenorhabditis elegans by scanning mutagenesis. J Biol Chem. 282, 14586-97.
• 1. Wang H
  2. Spang A
  3. Sullivan MA
  4. Hryhorenko J
  5. Hagen FK
  (2005 Sep 01). The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Mol Biol Cell. 16, 4202-13.
• 1. Wojczyk BS
  2. Stwora-Wojczyk MM
  3. Hagen FK
  4. Striepen B
  5. Hang HC
  6. Bertozzi CR
  7. Roos DS
  8. Spitalnik SL
  (2003 Oct 01). cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol Biochem Parasitol. 131, 93-107.
• 1. Ten Hagen KG
  2. Bedi GS
  3. Tetaert D
  4. Kingsley PD
  5. Hagen FK
  6. Balys MM
  7. Beres TM
  8. Degand P
  9. Tabak LA
  (2001 May 18). Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. J Biol Chem. 276, 17395-404.
• 1. Hagen FK
  2. Layden M
  3. Nehrke K
  4. Gentile K
  5. Berbach K
  6. Tsao CC
  7. Forsythe M
  (2001). Mucin-type O-Glycosylation in C. elegans is initiated by a family of glycosyltransferases. TIGG. 131, 463-479.
• 1. Ten Hagen KG
  2. Tetaert D
  3. Hagen FK
  4. Richet C
  5. Beres TM
  6. Gagnon J
  7. Balys MM
  8. VanWuyckhuyse B
  9. Bedi GS
  10. Degand P
  11. Tabak LA
  (1999 Sep 24). Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity. J Biol Chem. 274, 27867-74.
• 1. Hagen FK
  2. Hazes B
  3. Raffo R
  4. deSa D
  5. Tabak LA
  (1999 Mar 05). Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold. J Biol Chem. 274, 6797-803.
• 1. Ten Hagen KG
  2. Hagen FK
  3. Balys MM
  4. Beres TM
  5. Van Wuyckhuyse B
  6. Tabak LA
  (1998 Oct 16). Cloning and expression of a novel, tissue specifically expressed member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family. J Biol Chem. 273, 27749-54.
• 1. Hagen FK
  2. Nehrke K
  (1998 Apr 03). cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. J Biol Chem. 273, 8268-77.
• 1. Nehrke K
  2. Hagen FK
  3. Tabak LA
  (1998 Apr 01). Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo. Glycobiology. 8, 367-71.
• 1. Nehrke K
  2. Ten Hagen KG
  3. Hagen FK
  4. Tabak LA
  (1997 Dec 01). Charge distribution of flanking amino acids inhibits O-glycosylation of several single-site acceptors in vivo. Glycobiology. 7, 1053-60.
• 1. Wragg S
  2. Hagen FK
  3. Tabak LA
  (1997 Nov 15). Identification of essential histidine residues in UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T1. Biochem J. 328 ( Pt 1), 193-7.
• 1. Hagen FK
  2. Ten Hagen KG
  3. Beres TM
  4. Balys MM
  5. VanWuyckhuyse BC
  6. Tabak LA
  (1997 May 23). cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 272, 13843-8.
• 1. Zara J
  2. Hagen FK
  3. Ten Hagen KG
  4. Van Wuyckhuyse BC
  5. Tabak LA
  (1996 Nov 01). Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3. Biochem Biophys Res Commun. 228, 38-44.
• 1. Brockhausen I
  2. Toki D
  3. Brockhausen J
  4. Peters S
  5. Bielfeldt T
  6. Kleen A
  7. Paulsen H
  8. Meldal M
  9. Hagen F
  10. Tabak LA
  (1996 Oct 01). Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates. Glycoconj J. 13, 849-56.
• 1. Albone EF
  2. Hagen FK
  3. Szpirer C
  4. Tabak LA
  (1996 Oct 01). Molecular cloning and characterization of the gene encoding rat submandibular gland apomucin, Mucsmg. Glycoconj J. 13, 709-16.
• 1. Nehrke K
  2. Hagen FK
  3. Tabak LA
  (1996 Mar 22). Charge distribution of flanking amino acids influences O-glycan acquisition in vivo. J Biol Chem. 271, 7061-5.
• 1. Hennet T
  2. Hagen FK
  3. Tabak LA
  4. Marth JD
  (1995 Dec 19). T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 92, 12070-4.
• 1. Hagen FK
  2. Gregoire CA
  3. Tabak LA
  (1995 Dec 01). Cloning and sequence homology of a rat UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. Glycoconj J. 12, 901-9.
• 1. Wragg S
  2. Hagen FK
  3. Tabak LA
  (1995 Jul 14). Kinetic analysis of a recombinant UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 270, 16947-54.
• 1. Albone EF
  2. Hagen FK
  3. VanWuyckhuyse BC
  4. Tabak LA
  (1994 Jun 17). Molecular cloning of a rat submandibular gland apomucin. J Biol Chem. 269, 16845-52.
• 1. Hagen FK
  2. Van Wuyckhuyse B
  3. Tabak LA
  (1993 Sep 05). Purification, cloning, and expression of a bovine UDP-GalNAc: polypeptide N-acetyl-galactosaminyltransferase. J Biol Chem. 268, 18960-5.
• 1. O'Connell BC
  2. Hagen FK
  3. Tabak LA
  (1992 Dec 15). The influence of flanking sequence on the O-glycosylation of threonine in vitro. J Biol Chem. 267, 25010-8.
• 1. Aiken JM
  2. Miller FD
  3. Hagen F
  4. McKenzie DI
  5. Krawetz SA
  6. van de Sande JH
  7. Rattner JB
  8. Dixon GH
  (1985 Oct 22). Tandem repeats of a specific alternating purine-pyrimidine DNA sequence adjacent to protamine genes in the rainbow trout that can exist in the Z form. Biochemistry. 24, 6268-76.
• 1. Hagen FK
  2. Zarling DA
  3. Jovin TM
  (1985 Mar 01). Electron microscopy of SV40 DNA cross-linked by anti-Z DNA IgG. EMBO J. 4, 837-44.