Dr. Hayes is also the Principal Investigator of the William A. Bernhard Memorial Lab. Please visit the lab site to learn more about the physics & chemistry of DNA damage produced by ionizing radiation.
The protein-DNA assemblies that comprise chromatin serve to compact and store eukaryotic DNA in a systematic and orderly manner, and are involved in the regulation of nuclear processes such as transcription. Currently, research in the lab covers four areas related to chromatin structure and function.
- A distinct switch in interactions of the histone H4 tail domain upon salt-dependent folding of nucleosome arrays. J Biol Chem. 289, 27342-51. (2014 Sep 26).
- Intra- and inter-nucleosome interactions of the core histone tail domains in higher-order chromatin structure. Chromosoma. 123, 3-13. (2014 Mar 01).
- Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin. J Cell Biol. 203, 57-71. (2013 Oct 14).