Principal Investigator

Jeffrey J. Hayes, Ph.D. University of Rochester work Box 712 601 Elmwood Ave Rochester NY 14642 office: MC 3-6710 p (585) 273-4887 f (585) 275-6007

Research Projects

  • Interactions of the Core Histone Tail Domains

    Interactions of the Core Histone Tail Domains

    We are interested elucidating the mechanisms by which the core histone tail domains define the structural and functional state of nucleosomes and the chromatin fiber. To this end we prepare well-defined model chromatin complexes and chemically and spectroscopically probe structure and interactions in solution. More info...

  • Chromatin Structure Affects the Activity of DNA-Modifying Enzymes

    Chromatin Structure Affects the Activity of DNA-Modifying Enzymes

    We are investigating how chromatin structure effects the activity of DNA-modifying enzymes involved in DNA replication and base-excision repair (BER). Specifically, we have found that two enzymes involved in these processes, human DNA ligase I and FEN1, are able to operate surprisingly efficiently on nucleosome substrates. More info...

  • Mechanisms of ATP-dependent Chromatin Remodeling Complexes

    Mechanisms of ATP-dependent Chromatin Remodeling Complexes

    We have been investigating the mechanisms by which chromatin remodeling complexes use the energy of ATP hydrolysis to alter structure and accessibility in nucleosomes. Working with our collaborators has allowed us to investigate several aspects of the hSWI/SNF complex. More info...