Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.
Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
Minsoo Kim, Ph.D. Receives 2015 School of Medicine and Dentistry Trainee Academic Mentoring Award in Basic Science
Minsoo Kim to serve as member of the Atherosclerosis and Inflammation of the Cardiovascular Systems Study Section, Center for Scientific Review
- TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.J Cell Biol. 209, 143-62. (2015 Apr 13).
- Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.Blood. 124, 3515-23. (2014 Dec 04).
- Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.Neurobiol Aging. 35, 1286-92. (2014 Jun 01).