Principal Investigator

Minsoo Kim, Ph.D. University of Rochester work Rochester NY p (585) 276-3917

Contact

Minsoo Kim Lab University of Rochester work KMRB 3-9858 601 Elmwood Ave Rochester NY 14642 p (585) 273-1435

Affiliations

Inflammation Research

Live FRET image (VLA-4 activation) on TIRFM

Total integrin LFA-1 (red) and active LFA-1 (green) staining on human T cell

Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.

Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.