Research Projects

  • Activated Protein C in Sepsis

    Activated Protein C in Sepsis

    Sepsis, also known as systemic inflammatory response syndrome (SIRS) by infection, is a serious medical condition caused by inflammatory response which leads to secretion of pro- and anti-inflammatory cytokines, activation and migration of leukocytes, activation of coagulation and inhibition of fibrinolysis, and increased apoptosis. More info...

  • Mac-1 (CD11b/CD18) in neutrophil migration

    Mac-1 (CD11b/CD18) in neutrophil migration

    Neutrophils play key roles in the host defense network against pathogens by virtue of their abilities to phagocytose microorganisms and to produce oxygen free radicals and proteolytic enzymes. Extravasation of neutrophils from the blood stream proceeds through three coordinated steps: rolling and tethering, firm adhesion, and transmigration. The first step depends on the selectin molecules expressed on both neutrophils and endothelial cells (EC). More info...

  • T lymphocyte migration; live-cell imaging by a novel fluorescence-based technique

    T lymphocyte migration; live-cell imaging by a novel fluorescence-based technique

    A number of fundamental physiological processes are dependent on cell surface integrins including embryogenesis, development, inflammation, immune responsiveness, wound healing, and regulation of cell growth and differentiation. The role of integrins in the immune system is particularly complex as these molecules regulate many aspects of the immune response. This is so because unlike cells within solid tissues, circulating leukocytes relocate during the course of immune reactions and in so doing dynamically adhere and de-adhere to cells of the vasculature and to other immune cells, as well to components of the extracellular matrix. A subset of integrins (LFA-1 (CD11a/CD18), VLA-4 (α4β1), and α4β7)) are expressed on T lymphocytes and play a major role in regulating recirculation and tissue specific homing. More info...