October 23, 2013
Bethany Winans Receives Young Investigator Award
September 30, 2013
Paige Lawrence Receives New R01 Grant from NIEHS
Dr. Paige Lawrence, professor in the departments of Environmental Medicine and Microbiology & Immunology has received a new R01 grant from the National Institutes for Environmental Health Sciences (NIEHS), entitled Transgenerational exposures as modifiers of host defense against infection.
Along with UR Collaborators Steve Gill, Ph.D. and Sally Thurston, Ph.D., this project will explore exposure to pollutants can cause transgenerational changes in biological processes and contribute to disease. Since very little of this research has focused on transgenerational epigenetic inheritance of changes in immune function, the proposed research will direct address this deficit, and will study how a family of common pollutants perturbs the development and function of the immune system across generations.
The objective of this project is to define key parameters involved in transgenerational inheritance of alterations in the function of the mammalian immune system that occur as a result of environmental exposure. The immune system is fundamentally important to public and individual health, and even slight modifications in its function can have a profoundly negative impact on health and disease. For instance, influenza virus infections pose significant global health threats, infecting over 1 billion people annually. Evidence points to prenatal and early life exposure to pollutants as overlooked contributors to poorer clinical outcomes following influenza and other respiratory infections.
August 3, 2011
How exposure to chemicals and other environmental factors from the earliest months of life – even before we are born – affect our long-term health is the subject of a new five-year study by a scientist at the University of Rochester Medical Center.
B. Paige Lawrence, Ph.D., associate professor of Environmental Medicine and of Microbiology and Immunology, has been awarded $1.75 million by the National Institutes of Health to study how early exposure to factors in the environment affect our immune system.
- Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection. Am J Physiol Lung Cell Mol Physiol. 308, L76-85. (2015 Jan 01).
- Sex-specific enhanced behavioral toxicity induced by maternal exposure to a mixture of low dose endocrine-disrupting chemicals. Neurotoxicology. 45, 121-30. (2014 Dec 01).
- Effects of developmental activation of the AhR on CD4+ T-cell responses to influenza virus infection in adult mice. Environ Health Perspect. 122, 1201-8. (2014 Nov 01).