Principal Investigator

Sanjay Maggirwar, Ph.D. University of Rochester work Box 672 601 Elmwood Ave Rochester NY 14642 office: MRBX 2-11134 p 585-273-2276

Contact

Maggirwar Lab University of Rochester work Rochester NY p 585-273-2276 f 585-273-9573

Affiliations

Welcome to the Maggirwar Lab

Research Focus - Platelets, HIV and Inflammation

Despite the use of antiretroviral therapies, a majority of HIV infected individuals still develop HIV-associated neurocognitive disorders (HAND), indicating that host inflammatory mediators, in addition to viral proteins, may be contributing to these disorders. Our lab is interested in determining the mechanisms by which host factors are contributing to these disorders, with a large focus on alterations to the blood brain barrier (BBB) during infection that allow infiltration of the CNS by activated leukocytes. Specifically, we are focusing on the dysregulation of signaling events within platelets, leading to pro-inflammatory complications, as well as other cell types that are involved in regulation of the BBB such as pericytes, astrocytes, and endothelial cells that make up the neurovascular unit.

ExposuretoHIV1
Astrocyte

Recent Publications