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Principal Investigator

Mahin Maines, Ph.D. University of Rochester work Box 712 601 Elmwood Ave Rochester NY 14642 office: MC 5-8834 p 585-275-5383 f 585-275-6007 mahin_maines@urmc.rochester.edu

Recent Publications

The following list was auto-generated 2 weeks ago.

• 1. Miralem T
  2. Lerner-Marmarosh N
  3. Gibbs PE
  4. Tudor C
  5. Hagen FK
  6. Maines MD
  (2012 Jul 13). The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cδ activity: the peptides are inhibitors or substrate for the protein kinase C. J Biol Chem. 287, 24698-712.
• 1. Gibbs PE
  2. Miralem T
  3. Lerner-Marmarosh N
  4. Tudor C
  5. Maines MD
  (2012 Jan 06). Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS). J Biol Chem. 287, 1066-79.
• 1. Kapitulnik J
  2. Maines MD
  (2012 Jan 01). The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity, and cytoprotection. Front Pharmacol. 3, 136.
• 1. Gibbs PE
  2. Tudor C
  3. Maines MD
  (2012 Jan 01). Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C. Front Pharmacol. 3, 31.
• 1. Ding B
  2. Gibbs PE
  3. Brookes PS
  4. Maines MD
  (2011 Jan 01). The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction. FASEB J. 25, 301-13.
• 1. Maines MD
  (2010 Dec 01). Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings. Curr Drug Targets. 11, 1586-94.
• 1. Gibbs PE
  2. Miralem T
  3. Maines MD
  (2010 Sep 01). Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB. FASEB J. 24, 3239-54.
• 1. Miralem T
  2. Gibbs PE
  3. Revert F
  4. Saus J
  5. Maines MD
  (2010 Apr 23). Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression. J Biol Chem. 285, 12551-8.
• 1. Terrab A
  2. Ortiz MA
  3. Talavera M
  4. Ariza MJ
  5. Moriana Mdel C
  6. García-Castaño JL
  7. Tremetsberger K
  8. Stuessy TF
  9. Baeza CM
  10. Urtubey E
  11. Ruas Cde F
  12. Casimiro-Soriguer R
  13. Balao F
  14. Gibbs PE
  15. Talavera S
  (2009 Oct 01). AFLP and breeding system studies indicate vicariance origin for scattered populations and enigmatic low fecundity in the Moroccan endemic Hypochaeris angustifolia (Asteraceae), sister taxon to all of the South American Hypochaeris species. Mol Phylogenet Evol. 53, 13-22.
• 1. Kapitulnik J
  2. Maines MD
  (2009 Mar 01). Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin. Trends Pharmacol Sci. 30, 129-37.
• 1. Tudor C
  2. Lerner-Marmarosh N
  3. Engelborghs Y
  4. Gibbs PE
  5. Maines MD
  (2008 Aug 01). Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin. Biochem J. 413, 405-16.
• 1. Ortiz MA
  2. Tremetsberger K
  3. Terrab A
  4. Stuessy TF
  5. García-Castaño JL
  6. Urtubey E
  7. Baeza CM
  8. Ruas CF
  9. Gibbs PE
  10. Talavera S
  (2008 Aug 01). Phylogeography of the invasive weed Hypochaeris radicata (Asteraceae): from Moroccan origin to worldwide introduced populations. Mol Ecol. 17, 3654-67.
• 1. Lerner-Marmarosh N
  2. Miralem T
  3. Gibbs PE
  4. Maines MD
  (2008 May 13). Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc Natl Acad Sci U S A. 105, 6870-5.
• 1. Maines MD
  (2007 Dec 01). Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways. Antioxid Redox Signal. 9, 2187-95.
• 1. Gibbs PE
  2. Maines MD
  (2007 Dec 01). Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase. Int J Cancer. 121, 2567-74.
• 1. Lerner-Marmarosh N
  2. Miralem T
  3. Gibbs PE
  4. Maines MD
  (2007 Dec 01). Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB J. 21, 3949-62.
• 1. Maines MD
  2. Miralem T
  3. Lerner-Marmarosh N
  4. Shen J
  5. Gibbs PE
  (2007 Mar 16). Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. J Biol Chem. 282, 8110-22.
• 1. Zhang H
  2. Gibbs PE
  3. Lawrence CW
  (2006 Aug 01). The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigen. Genetics. 173, 1983-9.
• 1. Calabrese V
  2. Butterfield DA
  3. Scapagnini G
  4. Stella AM
  5. Maines MD
  (2006 May 08). Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity. Antioxid Redox Signal. 8, 444-77.
• 1. Calabrese V
  2. Maines MD
  (2006 May 08). Antiaging medicine: antioxidants and aging. Antioxid Redox Signal. 8, 362-4.
• 1. Ewing JF
  2. Maines MD
  (2006 Apr 01). Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response. J Neural Transm. 113, 439-54.
• 1. Maines MD
  (2005 Dec 16). The heme oxygenase system: update 2005. Antioxid Redox Signal. 7, 1761-6.
• 1. Maines MD
  2. Gibbs PE
  (2005 Dec 09). 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events. Biochem Biophys Res Commun. 338, 568-77.
• 1. Maines MD
  (2005 Dec 01). New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda). 20, 382-9.
• 1. Lerner-Marmarosh N
  2. Shen J
  3. Torno MD
  4. Kravets A
  5. Hu Z
  6. Maines MD
  (2005 May 17). Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc Natl Acad Sci U S A. 102, 7109-14.
• 1. Miralem T
  2. Hu Z
  3. Torno MD
  4. Lelli KM
  5. Maines MD
  (2005 Apr 29). Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. J Biol Chem. 280, 17084-92.
• 1. Maines MD
  (2004 Oct 01). The heme oxygenase system: past, present, and future. Antioxid Redox Signal. 6, 797-801.
• 1. Kravets A
  2. Hu Z
  3. Miralem T
  4. Torno MD
  5. Maines MD
  (2004 May 07). Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1. J Biol Chem. 279, 19916-23.
• 1. Mayer RD
  2. Wang X
  3. Maines MD
  (2003 Jul 01). Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase. J Pharmacol Exp Ther. 306, 43-50.
• 1. Wang X
  2. Hauptmann N
  3. Taylor E
  4. Foreman M
  5. Khawli LA
  6. Maines MD
  (2003 Feb 07). Neotrofin increases heme oxygenase-1 selectively in neurons. Brain Res. 962, 1-14.
• 1. Maines MD
  (2003 Jan 01). Bile pigments: newcomers to the cell signaling arena. Toxicol Sci. 71, 9-10.
• 1. Whitby FG
  2. Phillips JD
  3. Hill CP
  4. McCoubrey W
  5. Maines MD
  (2002 Jun 21). Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. J Mol Biol. 319, 1199-210.
• 1. Ahmad Z
  2. Salim M
  3. Maines MD
  (2002 Mar 15). Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress. J Biol Chem. 277, 9226-32.
• 1. Maines MD
  (2002 Jan 01). Heme oxygenase 1 transgenic mice as a model to study neuroprotection. Methods Enzymol. 353, 374-88.
• 1. Huang TJ
  2. McCoubrey WK
  3. Maines MD
  (2001 Aug 01). Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs. Antioxid Redox Signal. 3, 685-96.
• 1. Maines MD
  (2001 May 01). Overview of heme degradation pathway. Curr Protoc Toxicol. Chapter 9, Unit 9.1.
• 1. Salim M
  2. Brown-Kipphut BA
  3. Maines MD
  (2001 Apr 06). Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation. J Biol Chem. 276, 10929-34.
• 1. Maines MD
  2. Ewing JF
  3. Huang TJ
  4. Panahian N
  (2001 Mar 01). Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1. J Pharmacol Exp Ther. 296, 1091-7.
• 1. Maines MD
  2. Panahian N
  (2001 Jan 01). The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Adv Exp Med Biol. 502, 249-72.
• 1. Panahian N
  2. Maines MD
  (2001 Jan 01). Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms? J Neurochem. 76, 539-54.
• 1. Panahian N
  2. Maines MD
  (2000 Nov 01). Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion. Brain Res Brain Res Protoc. 6, 53-70.
• 1. Chen K
  2. Gunter K
  3. Maines MD
  (2000 Jul 01). Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem. 75, 304-13.
• 1. Chen K
  2. Maines MD
  (2000 May 01). Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cell Mol Biol (Noisy-le-grand). 46, 609-17.
• 1. Maines MD
  (2000 May 01). The heme oxygenase system and its functions in the brain. Cell Mol Biol (Noisy-le-grand). 46, 573-85.
• 1. Liu N
  2. Wang X
  3. McCoubrey WK
  4. Maines MD
  (2000 Jan 04). Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression. Gene. 241, 175-83.
• 1. Panahian N
  2. Huang T
  3. Maines MD
  (1999 Dec 11). Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia. Brain Res. 850, 1-13.
• 1. Maines MD
  2. Raju VS
  3. Panahian N
  (1999 Nov 01). Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury. J Pharmacol Exp Ther. 291, 911-9.
• 1. Maines MD
  2. Mayer RD
  3. Erturk E
  4. Huang TJ
  5. Disantagnese A
  (1999 Oct 01). The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity. J Urol. 162, 1467-72.
• 1. Ding Y
  2. McCoubrey WK
  3. Maines MD
  (1999 Sep 01). Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO? Eur J Biochem. 264, 854-61.
• 1. Panahian N
  2. Yoshiura M
  3. Maines MD
  (1999 Mar 01). Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem. 72, 1187-203.