Principal Investigator

James L. McGrath, Ph.D. University of Rochester work Box 270168 Rochester NY 14627-0168 office: Goergen Hall 306 p 585-273-5489 f 585-273-4746

Wound Healing

Simulation of the wound region. The computer model incorporates the dynamics of division, spreading and semi-persistent crawling that we measure for real cells. The small animation on the previous page is a zoomed in view of a simulated culture growing to confluence.

Through a combination of computer modeling and experimentation we are working toward a comprehensive understanding of monolayer sheet migration. Progress in this area could lead to strategies for the re-endothelialization of small diameter vascular grafts. These images show experimental and simulated wound healing 0, 12, and 24 hours after initial wounding.

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