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Principal Investigator

Maiken Nedergaard, M.D., DMSc University of Rochester work Box 645 601 Elmwood Ave Rochester NY 14642 office: KMRB 1-9915B p 585-273-2868 f 585-276-2298 nedergaard@urmc.rochester.edu

Recent Publications

The following list was auto-generated 1 week ago.

• 1. Ren Z
  2. Chen X
  3. Yang J
  4. Kress BT
  5. Tong J
  6. Liu H
  7. Takano T
  8. Zhao Y
  9. Nedergaard M
  (2013 Jun 25). Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter. Neuroscience. 241, 89-99.
• 1. Yang L
  2. Kress BT
  3. Weber HJ
  4. Thiyagarajan M
  5. Wang B
  6. Deane R
  7. Benveniste H
  8. Iliff JJ
  9. Nedergaard M
  (2013 May 01). Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med. 11, 107.
• 1. Thrane AS
  2. Takano T
  3. Rangroo Thrane V
  4. Wang F
  5. Peng W
  6. Ottersen OP
  7. Nedergaard M
  8. Nagelhus EA
  (2013 Apr 24). In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. J Cereb Blood Flow Metab. In press.
• 1. Goldman N
  2. Chandler-Militello D
  3. Langevin HM
  4. Nedergaard M
  5. Takano T
  (2013 Apr 01). Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. Cell Calcium. 53, 297-301.
• 1. Han X
  2. Chen M
  3. Wang F
  4. Windrem M
  5. Wang S
  6. Shanz S
  7. Xu Q
  8. Oberheim NA
  9. Bekar L
  10. Betstadt S
  11. Silva AJ
  12. Takano T
  13. Goldman SA
  14. Nedergaard M
  (2013 Mar 07). Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell. 12, 342-53.
• 1. Langevin H
  2. Fujita T
  3. Bouffard N
  4. Takano T
  5. Koptiuch C
  6. Badger G
  7. Nedergaard M
  (2013 Mar 04). Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling. J Cell Physiol. In press.
• 1. Iliff JJ
  2. Lee H
  3. Yu M
  4. Feng T
  5. Logan J
  6. Nedergaard M
  7. Benveniste H
  (2013 Mar 01). Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 123, 1299-309.
• 1. Ren Z
  2. Iliff JJ
  3. Yang L
  4. Yang J
  5. Chen X
  6. Chen MJ
  7. Giese RN
  8. Wang B
  9. Shi X
  10. Nedergaard M
  (2013 Feb 27). 'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation. J Cereb Blood Flow Metab. In press.
• 1. Langevin HM
  2. Nedergaard M
  3. Howe A
  (2013 Feb 26). Cellular control of connective tissue matrix tension. J Cell Biochem. In press.
• 1. Iliff JJ
  2. Nedergaard M
  (2013 Feb 01). A link between glial Ca2+ signaling and hypoxia in aging? J Cereb Blood Flow Metab. 33, 170.
• 1. Sun W
  2. McConnell E
  3. Pare JF
  4. Xu Q
  5. Chen M
  6. Peng W
  7. Lovatt D
  8. Han X
  9. Smith Y
  10. Nedergaard M
  (2013 Jan 11). Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science. 339, 197-200.
• 1. Wang M
  2. Iliff JJ
  3. Liao Y
  4. Chen MJ
  5. Shinseki MS
  6. Venkataraman A
  7. Cheung J
  8. Wang W
  9. Nedergaard M
  (2012 Dec 12). Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. J Neurosci. 32, 17948-60.
• 1. Bennett MV
  2. Garré JM
  3. Orellana JA
  4. Bukauskas FF
  5. Nedergaard M
  6. Sáez JC
  (2012 Dec 03). Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res. 1487, 3-15.
• 1. Cotrina ML
  2. Nedergaard M
  (2012 Dec 03). Brain connexins in demyelinating diseases: therapeutic potential of glial targets. Brain Res. 1487, 61-8.
• 1. Takano T
  2. Chen X
  3. Luo F
  4. Fujita T
  5. Ren Z
  6. Goldman N
  7. Zhao Y
  8. Markman JD
  9. Nedergaard M
  (2012 Dec 01). Traditional acupuncture triggers a local increase in adenosine in human subjects. J Pain. 13, 1215-23.
• 1. Enger R
  2. Gundersen GA
  3. Haj-Yasein NN
  4. Eilert-Olsen M
  5. Thoren AE
  6. Vindedal GF
  7. Petersen PH
  8. Skare Ø
  9. Nedergaard M
  10. Ottersen OP
  11. Nagelhus EA
  (2012 Dec 01). Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse. Glia. 60, 2018-26.
• 1. Bekar LK
  2. Wei HS
  3. Nedergaard M
  (2012 Dec 01). The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. J Cereb Blood Flow Metab. 32, 2135-45.
• 1. Thrane AS
  2. Rangroo Thrane V
  3. Zeppenfeld D
  4. Lou N
  5. Xu Q
  6. Nagelhus EA
  7. Nedergaard M
  (2012 Nov 13). General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc Natl Acad Sci U S A. 109, 18974-9.
• 1. Chen MJ
  2. Kress B
  3. Han X
  4. Moll K
  5. Peng W
  6. Ji RR
  7. Nedergaard M
  (2012 Nov 01). Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia. 60, 1660-70.
• 1. O'Donnell J
  2. Zeppenfeld D
  3. McConnell E
  4. Pena S
  5. Nedergaard M
  (2012 Nov 01). Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem Res. 37, 2496-512.
• 1. Goldman SA
  2. Nedergaard M
  3. Windrem MS
  (2012 Oct 26). Glial progenitor cell-based treatment and modeling of neurological disease. Science. 338, 491-5.
• 1. Rangroo Thrane V
  2. Thrane AS
  3. Chang J
  4. Chanag J
  5. Alleluia V
  6. Nagelhus EA
  7. Nedergaard M
  (2012 Sep 18). Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy. Neuroscience. 220, 247-55.
• 1. Iliff JJ
  2. Wang M
  3. Liao Y
  4. Plogg BA
  5. Peng W
  6. Gundersen GA
  7. Benveniste H
  8. Vates GE
  9. Deane R
  10. Goldman SA
  11. Nagelhus EA
  12. Nedergaard M
  (2012 Aug 15). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 4, 147ra111.
• 1. Nedergaard M
  2. Verkhratsky A
  (2012 Jul 01). Artifact versus reality--how astrocytes contribute to synaptic events. Glia. 60, 1013-23.
• 1. Wang F
  2. Xu Q
  3. Wang W
  4. Takano T
  5. Nedergaard M
  (2012 May 15). Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake. Proc Natl Acad Sci U S A. 109, 7911-6.
• 1. Lovatt D
  2. Xu Q
  3. Liu W
  4. Takano T
  5. Smith NA
  6. Schnermann J
  7. Tieu K
  8. Nedergaard M
  (2012 Apr 17). Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci U S A. 109, 6265-70.
• 1. Messing A
  2. Brenner M
  3. Feany MB
  4. Nedergaard M
  5. Goldman JE
  (2012 Apr 11). Alexander disease. J Neurosci. 32, 5017-23.
• 1. Wang F
  2. Smith NA
  3. Xu Q
  4. Fujita T
  5. Baba A
  6. Matsuda T
  7. Takano T
  8. Bekar L
  9. Nedergaard M
  (2012 Apr 03). Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. Sci Signal. 5, ra26.
• 1. Nedergaard MK
  2. Hedegaard CJ
  3. Poulsen HS
  (2012 Apr 01). Targeting the epidermal growth factor receptor in solid tumor malignancies. BioDrugs. 26, 83-99.
• 1. Huang C
  2. Han X
  3. Li X
  4. Lam E
  5. Peng W
  6. Lou N
  7. Torres A
  8. Yang M
  9. Garre JM
  10. Tian GF
  11. Bennett MV
  12. Nedergaard M
  13. Takano T
  (2012 Mar 07). Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 32, 3333-8.
• 1. Torres A
  2. Wang F
  3. Xu Q
  4. Fujita T
  5. Dobrowolski R
  6. Willecke K
  7. Takano T
  8. Nedergaard M
  (2012 Jan 24). Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia. Sci Signal. 5, ra8.
• 1. Verkhratsky A
  2. Sofroniew MV
  3. Messing A
  4. deLanerolle NC
  5. Rempe D
  6. Rodríguez JJ
  7. Nedergaard M
  (2012 Jan 01). Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro. 4, .
• 1. Oberheim NA
  2. Goldman SA
  3. Nedergaard M
  (2012 Jan 01). Heterogeneity of astrocytic form and function. Methods Mol Biol. 814, 23-45.
• 1. Fujita T
  2. Williams EK
  3. Jensen TK
  4. Smith NA
  5. Takano T
  6. Tieu K
  7. Nedergaard M
  (2012 Jan 01). Cultured astrocytes do not release adenosine during hypoxic conditions. J Cereb Blood Flow Metab. 32, e1-7.
• 1. Christensen DJ
  2. Nedergaard M
  (2011 Sep 01). Two-photon in vivo imaging of cells. Pediatr Nephrol. 26, 1483-9.
• 1. Thrane AS
  2. Rappold PM
  3. Fujita T
  4. Torres A
  5. Bekar LK
  6. Takano T
  7. Peng W
  8. Wang F
  9. Rangroo Thrane V
  10. Enger R
  11. Haj-Yasein NN
  12. Skare Ø
  13. Holen T
  14. Klungland A
  15. Ottersen OP
  16. Nedergaard M
  17. Nagelhus EA
  (2011 Jan 11). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 108, 846-51.
• 1. Kasischke KA
  2. Lambert EM
  3. Panepento B
  4. Sun A
  5. Gelbard HA
  6. Burgess RW
  7. Foster TH
  8. Nedergaard M
  (2011 Jan 01). Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J Cereb Blood Flow Metab. 31, 68-81.
• 1. Hertz L
  2. Lovatt D
  3. Goldman SA
  4. Nedergaard M
  (2010 Nov 01). Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochem Int. 57, 411-20.
• 1. Kimelberg HK
  2. Nedergaard M
  (2010 Oct 01). Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics. 7, 338-53.
• 1. Rempe DA
  2. Nedergaard M
  (2010 Oct 01). Targeting glia for treatment of neurological disease. Neurotherapeutics. 7, 335-7.
• 1. Kang J
  2. Kang N
  3. Yu Y
  4. Zhang J
  5. Petersen N
  6. Tian GF
  7. Nedergaard M
  (2010 Sep 15). Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons. Neuroscience. 169, 1601-9.
• 1. Vates GE
  2. Takano T
  3. Zlokovic B
  4. Nedergaard M
  (2010 Sep 01). Pericyte constriction after stroke: the jury is still out. Nat Med. 16, 959; author reply 960.
• 1. Goldman N
  2. Chen M
  3. Fujita T
  4. Xu Q
  5. Peng W
  6. Liu W
  7. Jensen TK
  8. Pei Y
  9. Wang F
  10. Han X
  11. Chen JF
  12. Schnermann J
  13. Takano T
  14. Bekar L
  15. Tieu K
  16. Nedergaard M
  (2010 Jul 01). Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 13, 883-8.
• 1. Zhang S
  2. Li B
  3. Lovatt D
  4. Xu J
  5. Song D
  6. Goldman SA
  7. Nedergaard M
  8. Hertz L
  9. Peng L
  (2010 May 01). 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol. 6, 113-25.
• 1. Nedergaard M
  2. Verkhratsky A
  (2010 Feb 01). Calcium dyshomeostasis and pathological calcium signalling in neurological diseases. Cell Calcium. 47, 101-2.
• 1. Nedergaard M
  2. Rodríguez JJ
  3. Verkhratsky A
  (2010 Feb 01). Glial calcium and diseases of the nervous system. Cell Calcium. 47, 140-9.
• 1. Rempe DA
  2. Takano T
  3. Nedergaard M
  (2009 Oct 01). TR(I)Pping towards treatment for ischemia. Nat Neurosci. 12, 1215-6.
• 1. Peng W
  2. Cotrina ML
  3. Han X
  4. Yu H
  5. Bekar L
  6. Blum L
  7. Takano T
  8. Tian GF
  9. Goldman SA
  10. Nedergaard M
  (2009 Jul 28). Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U S A. 106, 12489-93.
• 1. Cotrina ML
  2. Nedergaard M
  (2009 Jun 01). Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal. 5, 223-32.
• 1. Oberheim NA
  2. Takano T
  3. Han X
  4. He W
  5. Lin JH
  6. Wang F
  7. Xu Q
  8. Wyatt JD
  9. Pilcher W
  10. Ojemann JG
  11. Ransom BR
  12. Goldman SA
  13. Nedergaard M
  (2009 Mar 11). Uniquely hominid features of adult human astrocytes. J Neurosci. 29, 3276-87.