Principal Investigator

Irfan Rahman, Ph.D. University of Rochester work Box 850 601 Elmwood Ave Rochester NY 14642 office: MRBX 3-11106 p (585) 275-6911

Contact

Irfan Rahman Lab University of Rochester work MRBX 3-11001 601 Elmwood Ave Rochester NY 14642 p (585) 273-2843

Affiliations

Welcome to the Rahman Lab

My laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation and DNA methylation), involvement of anti-inflammatory and anti-aging proteins sirtuins, HDACs, DNA damage/repair, and cellular senescence in chronic lung inflammatory diseases including COPD. Recent research includes in understanding the role of sirtuins/HDACs in aging and accelerated decline in lung function, cellular senescence, and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in the pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants (tobacco smoke, e-cigarettes, oxidants/aldehydes), identifying molecular targets, and the potential benefit of therapeutic interventions in airways disease.

Current Research Projects

New Book

Inflammation, Advancing Age and Nutrition, 1st Edition

Purchase at the Elsevier Store

Recent Publications