Principal Investigator

Jacques Robert, Ph.D. University of Rochester work Box 672 Rochester NY

Research Projects

  • Evolution of Activation-Induced Deaminase (AID)

    Evolution of Activation-Induced Deaminase (AID)

    In collaboration with Andrea Bottaro (Dept. of Medicine -Allergy/Immunology Unit), we have recently begun to study the structural and functional conservation of AID in Xenopus. Activation-induced deaminase (AID) is an activated B cell-specific cytidine deaminase enzyme required for both immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM). More info...

  • Evolution of Leukocyte Fc and Natural Killer Cell Receptors

    Evolution of Leukocyte Fc and Natural Killer Cell Receptors

    The families of leukocyte Fc receptors (FcR) and killer cell immunoglobulin-like receptors (KIRs) are important groups of surface molecules participating in adaptive and innate immunity whose phylogenetic history and relatedness is unknown. Our recent studies suggesting a role of NK cells and CD8 NK/T cells in Xenopus anti-tumor responses stimulated by hsps, make it important to learn more about the NK cell receptors that signal activation and inhibition of killing in this species. More info...

  • Evolution of hsp/hsp Receptor Interactions

    Evolution of hsp/hsp Receptor Interactions

    CD91, the endocytic receptor for a2-macroglobulin (a2-M), in mammals mediates the internalization of certain hsps and the cross-presentation of peptides they chaperone by antigen presenting cells. The phylogenetic conservation of the immunologically active CD91 ligands, a2-M and hsps, is consistent with the idea of an ancestral system of immune surveillance. More info...

  • Heat Shock Proteins and Tumor Immunity

    Heat Shock Proteins and Tumor Immunity

    We are investigating the postulated dual role of some heat shock proteins (hsps) as components of an ancestral system of immune surveillance involved in antigen presentation (adaptive immunity) as well as in danger signaling (innate immunity). Our Xenopus model allows us to study the immunological properties of hsps in the presence (adult) or absence (tadpole) of MHC class I presentation. More info...

  • Immune Responses to Emerging Ranaviral Diseases

    Immune Responses to Emerging Ranaviral Diseases

    Although rapid progress has been made in identifying genes involved in innate (NK-receptor genes) and adaptive (TCR and MHC genes) immunity, very little is known about the roles and relative importance of innate and adaptive anti-viral immunity in ectothermic vertebrates. More info...