Principal Investigator

Elena P. Rustchenko-Bulgac, Ph.D. University of Rochester work Box 712 601 Elmwood Ave Rochester NY 14642 office: MC 6-8818 p (585) 275-6710 f (585) 271-2683

Contact

Rustchenko-Bulgac Lab University of Rochester work MC 6-8818 601 Elmwood Ave Rochester NY 14642 p (585) 275-6710 f (585) 275-6007

Affiliation

Chromosome Instability

Mammary Fat pad

Candida albicans

Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.

We made the remarkable discovery that C. albicans evolved an unusual mechanism of survival in adverse environments that cause lethality or inhibit growth. Using four different environments, we demonstrated that this naturally diploid microbe survived in a specific environment by altering a specific chromosome. Alterations included loss and gain of the entire chromosomes or loss and gain of the large portions of chromosomes. For example, survival on the medium containing the toxic sugar L-sorbose involved predominantly the formation of monosomy of chromosome 5 (Ch5).

Recent Publications

    1. Yada K
    2. Nogami K
    3. Takeyama M
    4. Ogiwara K
    5. Wakabayashi H
    6. Shima M
    (2015 Aug 17). Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.J Thromb Haemost.
    1. Taniguchi Y
    2. Takahashi Y
    3. Toba T
    4. Yamada S
    5. Yokoi K
    6. Kobayashi S
    7. Okajima S
    8. Shimane A
    9. Kawai H
    10. Yasaka Y
    11. Smanio P
    12. Oliveira MA
    13. Machado L
    14. Cestari P
    15. Medeiros E
    16. Fukuzawa S
    17. Okino S
    18. Ikeda A
    19. Maekawa J
    20. Ichikawa S
    21. Kuroiwa N
    22. Yamanaka K
    23. Igarashi A
    24. Inagaki M
    25. Patel K
    26. Mahan M
    27. Ananthasubramaniam K
    28. Mouden M
    29. Yokota S
    30. Ottervanger JP
    31. Knollema S
    32. Timmer JR
    33. Jager PL
    34. Padron K
    35. Peix A
    36. Cabrera LO
    37. Pena Bofill V
    38. Valera D
    39. Rodriguez Nande L
    40. Carrillo Hernandez R
    41. Mena Esnard E
    42. Fernandez Columbie Y
    43. Bertella E
    44. Baggiano A
    45. Mushtaq S
    46. Segurini C
    47. Loguercio M
    48. Conte E
    49. Beltrama V
    50. Petulla' M
    51. Andreini D
    52. Pontone G
    53. Guzic Salobir B
    54. Dolenc Novak M
    55. Jug B
    56. Kacjan B
    57. Novak Z
    58. Vrtovec M
    59. Mushtaq S
    60. Pontone G
    61. Bertella E
    62. Conte E
    63. Segurini C
    64. Volpato V
    65. Baggiano A
    66. Formenti A
    67. Pepi M
    68. Andreini D
    69. Ajanovic R
    70. Husic-Selimovic A
    71. Zujovic-Ajanovic A
    72. Mlynarski R
    73. Mlynarska A
    74. Golba K
    75. Sosnowski M
    76. Ameta D
    77. Goyal M
    78. Kumar D
    79. Chandra S
    80. Sethi R
    81. Puri A
    82. Dwivedi SK
    83. Narain VS
    84. Saran RK
    85. Nekolla S
    86. Rischpler C
    87. Nicolosi S
    88. Langwieser N
    89. Dirschinger R
    90. Laugwitz KL
    91. Schwaiger M
    92. Goral JL
    93. Napoli J
    94. Forcada PJ
    95. Zucchiatti NE
    96. Damico AC
    97. Damico AE
    98. Olivieri DB
    99. Lavorato MA
    100. Dubesarsky EA
    101. Montana OR
    102. Salgado C
    103. Jimenez-Heffernan A
    104. Ramos-Font C
    105. Lopez-Martin J
    106. Sanchez De Mora E
    107. Lopez-Aguilar R
    108. Manovel A
    109. Martinez AB
    110. Rivera F
    111. Soriano E
    112. Maroz-Vadalazhskaya N
    113. Trisvetova E
    114. Vrublevskaya O
    115. Abazid R
    116. Kattea M
    117. Saqqah H
    118. Sayed S
    119. Smettei O
    120. Winther S
    121. Svensson M
    122. Birn H
    123. Jorgensen HS
    124. Botker HE
    125. Ivarsen P
    126. Bottcher M
    127. Maaniitty T
    128. Stenstrom I
    129. Saraste A
    130. Pikkarainen E
    131. Uusitalo V
    132. Ukkonen H
    133. Kajander S
    134. Bax J
    135. Knuuti J
    136. Choi TY
    137. Park HB
    138. Lee CH
    139. Lee JH
    140. Seo YS
    141. Cho YH
    142. Hwang ES
    143. Cho DK
    144. Sanchez Enrique C
    145. Ferrera C
    146. Olmos C
    147. Jimenez-Ballve A
    148. Perez-Castejon MJ
    149. Fernandez C
    150. Vivas D
    151. Vilacosta I
    152. Nagamachi S
    153. Onizuka H
    154. Nishii R
    155. Mizutani Y
    156. Kitamura K
    157. Lo Presti M
    158. Polizzi V
    159. Pino PG
    160. Luzi G
    161. Bellavia D
    162. Fiorilli R
    163. Madeo A
    164. Malouf J
    165. Buffa V
    166. Musumeci F
    167. Rosales S
    168. Puente A
    169. Zafrir N
    170. Shochat T
    171. Mats A
    172. Solodky A
    173. Kornowski R
    174. Lorber A
    175. Boemio A
    176. Pellegrino T
    177. Paolillo S
    178. Piscopo V
    179. Carotenuto R
    180. Russo B
    181. Pellegrino S
    182. De Matteis G
    183. Perrone-Filardi P
    184. Cuocolo A
    185. Piscopo V
    186. Pellegrino T
    187. Boemio A
    188. Carotenuto R
    189. Russo B
    190. Pellegrino S
    191. De Matteis G
    192. Petretta M
    193. Cuocolo A
    194. Amirov N
    195. Ibatullin M
    196. Sadykov A A
    197. Saifullina G
    198. Ruano R
    199. Diego Dominguez M
    200. Rodriguez Gabella T
    201. Diego Nieto A
    202. Diaz Gonzalez LG
    203. Garcia-Talavera JR
    204. Sanchez Fernandez PL
    205. Leen AC
    206. Al Younis I
    207. Zandbergen-Harlaar S
    208. Verberne HJ
    209. Gimelli A
    210. Veltman CE
    211. Wolterbeek R
    212. Bax JJ
    213. Scholte A
    214. Mooney D
    215. Rosenblatt JA
    216. Dunn TL
    217. Vasaiwala SC
    218. Okuda K
    219. Nakajima K
    220. Nystrom K
    221. Edenbrandt L
    222. Matsuo S
    223. Wakabayashi H
    224. Hashimoto M
    225. Kinuya S
    226. Iric-Cupic V
    227. Milanov S
    228. Davidovic G
    229. Zdravkovic V
    230. Ashikaga K
    231. Yoneyama K
    232. Akashi Y
    233. Shugushev Z
    234. Maximkin D
    235. Chepurnoy A
    236. Volkova O
    237. Baranovich V
    238. Faibushevich A
    239. El Tahlawi M
    240. Elmurr A
    241. Alzubaidi S
    242. Sakrana A
    243. Gouda M
    244. El Tahlawi R
    245. Sellem A
    246. Melki S
    247. Elajmi W
    248. Hammami H
    249. Okano M
    250. Kato T
    251. Kimura M
    252. Funasako M
    253. Nakane E
    254. Miyamoto S
    255. Izumi T
    256. Haruna T
    257. Inoko M
    258. Massardo T
    259. Swett E
    260. Fernandez R
    261. Vera V
    262. Zhindon J
    263. Fernandez R
    264. Swett E
    265. Vera V
    266. Zhindon JP
    267. Alay R
    268. Massardo T
    269. Ohshima S
    270. Nishio M
    271. Kojima A
    272. Tamai S
    273. Kobayashi T
    274. Murohara T
    275. Burrell S
    276. Van Rosendael A
    277. Van Den Hoogen I
    278. De Graaf MA
    279. Roelofs J
    280. Kroft LJ
    281. Bax JJ
    282. Scholte AJ
    283. Rjabceva I
    284. Krumina G
    285. Kalvelis A
    286. Chanakhchyan F
    287. Vakhromeeva M
    288. Kankiya E
    289. Koppes J
    290. Knol R
    291. Wondergem M
    292. Van Der Ploeg T
    293. Van Der Zant FM
    294. Lazarenko SV
    295. Bruin VS
    296. Pan XB
    297. Declerck JM
    298. Van Der Zant FM
    299. Knol RJ
    300. Juarez-Orozco LE
    301. Alexanderson E
    302. Slart R
    303. Tio RA
    304. Dierckx RA
    305. Zeebregts CJ
    306. Boersma HH
    307. Hillege HL
    308. Martinez-Aguilar MM
    309. Jordan-Rios A
    310. Christensen TE
    311. Ahtarovski KA
    312. Bang LE
    313. Holmvang L
    314. Soeholm H
    315. Ghotbi AA
    316. Andersson H
    317. Ihlemann N
    318. Kjaer A
    319. Hasbak P
    320. Gulya M
    321. Lishmanov YB
    322. Zavadovskii KW
    323. Lebedev DI
    324. Stahle M
    325. Hellberg S
    326. Liljenback H
    327. Virta J
    328. Metsala O
    329. Yla-Herttuala S
    330. Saukko P
    331. Knuuti J
    332. Saraste A
    333. Roivainen A
    334. Thackeray JT
    335. Wang Y
    336. Bankstahl JP
    337. Wollert KC
    338. Bengel FM
    339. Saushkina YU
    340. Evtushenko V
    341. Minin S
    342. Efimova I
    343. Evtushenko A
    344. Smishlyaev K
    345. Lishmanov YU
    346. Maslov L
    347. Okuda K
    348. Nakajima K
    349. Kirihara Y
    350. Sugino S
    351. Matsuo S
    352. Taki J
    353. Hashimoto M
    354. Kinuya S
    355. Ahmadian A
    356. Berman J
    357. Govender P
    358. Ruberg F
    359. Miller E
    360. Piriou N
    361. Pallardy A
    362. Valette F
    363. Cahouch Z
    364. Mathieu C
    365. Warin-Fresse K
    366. Gueffet JP
    367. Serfaty JM
    368. Trochu JN
    369. Kraeber-Bodere F
    370. Van Dijk JD
    371. Mouden M
    372. Ottervanger JP
    373. Van Dalen JA
    374. Jager PL
    375. Zafrir N
    376. Ofrk H
    377. Vaturi M
    378. Shochat T
    379. Hassid Y
    380. Belzer D
    381. Sagie A
    382. Kornowski R
    383. Kaminek M
    384. Metelkova I
    385. Budikova M
    386. Koranda P
    387. Henzlova L
    388. Sovova E
    389. Kincl V
    390. Drozdova A
    391. Jordan M
    392. Shahid F
    393. Teoh YP
    394. Thamen R
    395. Hara N
    396. Onoguchi M
    397. Hojyo O
    398. Kawaguchi Y
    399. Murai M
    400. Udaka F
    401. Matsuzawa Y
    402. Bulugahapitiya DS
    403. Avison M
    404. Martin J
    405. Liu YH
    406. Wu J
    407. Liu C
    408. Sinusas A
    409. Daou D
    410. Sabbah R
    411. Bouladhour H
    412. Coaguila C
    413. Aguade-Bruix S
    414. Pizzi MN
    415. Romero-Farina G
    416. Candell-Riera J
    417. Castell-Conesa J
    418. Patchett N
    419. Sverdlov A
    420. Miller E
    421. Daou D
    422. Sabbah R
    423. Bouladhour H
    424. Coaguila C
    425. Smettei O
    426. Abazid R
    427. Boulaamayl El Fatemi S
    428. Sallam L
    429. Snipelisky D
    430. Park J
    431. Ray J
    432. Shapiro BS
    433. Kostkiewicz M
    434. Szot W
    435. Holcman K
    436. Lesniak-Sobelga A
    437. Podolec P
    438. Clerc OF
    439. Possner M
    440. Liga R
    441. Vontobel J
    442. Mikulicic F
    443. Graeni C
    444. Benz DC
    445. Herzog BA
    446. Gaemperli O
    447. Kaufmann PA
    (2015 May 01). Poster Session 1: Sunday 3 May 2015, 08:30-18:00Room: Poster Area.Eur Heart J Cardiovasc Imaging. 16 Suppl 1, i11-i28.
    1. Leong L
    2. Sim D
    3. Patel C
    4. Tran K
    5. Liu P
    6. Ho E
    7. Thompson T
    8. Kretschmer PJ
    9. Wakabayashi H
    10. Fay PJ
    11. Murphy JE
    (2015 Jan 08). Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models.Blood. 125, 392-8.