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Rustchenko-Bulgac Lab

URMC / Labs / Rustchenko-Bulgac Lab / Projects

 

Research Projects

Sorbose-utilizing Mutants Monosomic for Ch5

Sorbose-utilizing Mutants Monosomic for Ch5Detailed studies of sorbose-utilizing mutants monosomic for Ch5 provided an understanding of some aspects of the mechanism of regulation as based on diminution of chromosome copy number. Ch5 monosomy and re-duplication occur at high frequencies with a high degree of fidelity, which fulfills a requirement for regulatory systems.

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Tolerance to drugs from echinocandin class: caspofungin, anidulafungin and micafungin

Tolerance to drugs from echinocandin classOur studies of the control of resistance to sorbose have provided a foundation on which to understand how this organism responds to antifungal drugs. When we generated mutants on medium supplemented with fluconazole, a major anticandidal drug from azole class of drugs, we found that these mutants are adapted to fluconazole due to alteration of copy number of a specific chromosome.

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