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Principal Investigator

Edward M. Schwarz, Ph.D. University of Rochester work Box 665 Rochester NY p 585-275-3063 edward_schwarz@urmc.rochester.edu

Recent Publications

The following list was auto-generated 6 days ago.

• 1. Green JM
  2. Hallab NJ
  3. Liao YS
  4. Narayan V
  5. Schwarz EM
  6. Xie C
  (2013 May 01). Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. Curr Rheumatol Rep. 15, 325.
• 1. Dhillon RS
  2. Xie C
  3. Tyler W
  4. Calvi LM
  5. Awad HA
  6. Zuscik MJ
  7. O'Keefe RJ
  8. Schwarz EM
  (2013 Mar 01). PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. J Bone Miner Res. 28, 586-97.
• 1. Inzana JA
  2. Maher JR
  3. Takahata M
  4. Schwarz EM
  5. Berger AJ
  6. Awad HA
  (2013 Feb 22). Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis. J Biomech. 46, 723-30.
• 1. Juneja SC
  2. Schwarz EM
  3. O'Keefe RJ
  4. Awad HA
  (2013 Jan 01). Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis. Connect Tissue Res. 54, 218-26.
• 1. Li J
  2. Ju Y
  3. Bouta EM
  4. Xing L
  5. Wood RW
  6. Kuzin I
  7. Bottaro A
  8. Ritchlin CT
  9. Schwarz EM
  (2013 Jan 01). Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow. Arthritis Rheum. 65, 130-8.
• 1. Takahata M
  2. Maher JR
  3. Juneja SC
  4. Inzana J
  5. Xing L
  6. Schwarz EM
  7. Berger AJ
  8. Awad HA
  (2012 Nov 01). Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. Arthritis Rheum. 64, 3649-59.
• 1. Dhillon RS
  2. Schwarz EM
  3. Maloney MD
  (2012 Aug 08). Platelet-rich plasma therapy - future or trend? Arthritis Res Ther. 14, 219.
• 1. Wang M
  2. Tang D
  3. Shu B
  4. Wang B
  5. Jin H
  6. Hao S
  7. Dresser KA
  8. Shen J
  9. Im HJ
  10. Sampson ER
  11. Rubery PT
  12. Zuscik MJ
  13. Schwarz EM
  14. O'Keefe RJ
  15. Wang Y
  16. Chen D
  (2012 Aug 01). Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum. 64, 2611-23.
• 1. Moshkani S
  2. Kuzin II
  3. Adewale F
  4. Jansson J
  5. Sanz I
  6. Schwarz EM
  7. Bottaro A
  (2012 Jun 15). CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential. J Immunol. 188, 5944-53.
• 1. Ju Y
  2. Rahimi H
  3. Li J
  4. Wood RW
  5. Xing L
  6. Schwarz EM
  (2012 Jun 01). Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive inflammatory arthritis in mice. Arthritis Rheum. 64, 2048-50.
• 1. Dong Z
  2. Wu Y
  3. Wang Q
  4. Xie C
  5. Ren Y
  6. Clark RL
  (2012 Apr 01). Reinforcement of electrospun membranes using nanoscale Al2O3 whiskers for improved tissue scaffolds. J Biomed Mater Res A. 100, 903-10.
• 1. Takahata M
  2. Awad HA
  3. O'Keefe RJ
  4. Bukata SV
  5. Schwarz EM
  (2012 Mar 01). Endogenous tissue engineering: PTH therapy for skeletal repair. Cell Tissue Res. 347, 545-52.
• 1. Xie C
  2. Schwarz EM
  3. Sampson ER
  4. Dhillon RS
  5. Li D
  6. O'Keefe RJ
  7. Tyler W
  (2012 Feb 01). Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression. J Orthop Res. 30, 325-33.
• 1. Farhat YM
  2. Al-Maliki AA
  3. Chen T
  4. Juneja SC
  5. Schwarz EM
  6. O'Keefe RJ
  7. Awad HA
  (2012 Jan 01). Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing. PLoS One. 7, e51411.
• 1. Loiselle AE
  2. Frisch BJ
  3. Wolenski M
  4. Jacobson JA
  5. Calvi LM
  6. Schwarz EM
  7. Awad HA
  8. O'Keefe RJ
  (2012 Jan 01). Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury. PLoS One. 7, e40602.
• 1. Chiu YH
  2. Mensah KA
  3. Schwarz EM
  4. Ju Y
  5. Takahata M
  6. Feng C
  7. McMahon LA
  8. Hicks DG
  9. Panepento B
  10. Keng PC
  11. Ritchlin CT
  (2012 Jan 01). Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res. 27, 79-92.
• 1. Takahata M
  2. Schwarz EM
  3. Chen T
  4. O'Keefe RJ
  5. Awad HA
  (2012 Jan 01). Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction. J Bone Miner Res. 27, 26-37.
• 1. Bouta EM
  2. Wood RW
  3. Perry SW
  4. Brown EB
  5. Ritchlin CT
  6. Xing L
  7. Schwarz EM
  (2011 Dec 01). Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes. Ann N Y Acad Sci. 1240, 47-52.
• 1. Sampson ER
  2. Hilton MJ
  3. Tian Y
  4. Chen D
  5. Schwarz EM
  6. Mooney RA
  7. Bukata SV
  8. O'Keefe RJ
  9. Awad H
  10. Puzas JE
  11. Rosier RN
  12. Zuscik MJ
  (2011 Sep 21). Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med. 3, 101ra93.
• 1. Papuga MO
  2. Kwok E
  3. You Z
  4. Rubery PT
  5. Dougherty PE
  6. Pryhuber G
  7. Beck CA
  8. Hilton MJ
  9. Awad HA
  10. Schwarz EM
  (2011 Sep 01). TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. J Orthop Res. 29, 1367-74.
• 1. Sampson ER
  2. Beck CA
  3. Ketz J
  4. Canary KL
  5. Hilton MJ
  6. Awad H
  7. Schwarz EM
  8. Chen D
  9. O'Keefe RJ
  10. Rosier RN
  11. Zuscik MJ
  (2011 Aug 01). Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res. 29, 1145-51.
• 1. Yazici C
  2. Takahata M
  3. Reynolds DG
  4. Xie C
  5. Samulski RJ
  6. Samulski J
  7. Beecham EJ
  8. Gertzman AA
  9. Spilker M
  10. Zhang X
  11. O'Keefe RJ
  12. Awad HA
  13. Schwarz EM
  (2011 Aug 01). Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Mol Ther. 19, 1416-25.
• 1. Dhillon RS
  2. Schwarz EM
  (2011 Jun 01). Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials. J Mater Res. 4, 1117-1131.
• 1. Sampson ER
  2. Martin BA
  3. Morris AE
  4. Xie C
  5. Schwarz EM
  6. O'Keefe RJ
  7. Rosier RN
  (2011 Jun 01). The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model. J Bone Miner Res. 26, 1283-94.
• 1. Varrone JJ
  2. Li D
  3. Daiss JL
  4. Schwarz EM
  (2011 Apr 01). Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections. Bonekey Osteovision. 8, 187-194.
• 1. Sampson ER
  2. Amin V
  3. Schwarz EM
  4. O'Keefe RJ
  5. Rosier RN
  (2011 Apr 01). The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy. J Orthop Res. 29, 623-32.
• 1. Zhang M
  2. Ho HC
  3. Sheu TJ
  4. Breyer MD
  5. Flick LM
  6. Jonason JH
  7. Awad HA
  8. Schwarz EM
  9. O'Keefe RJ
  (2011 Apr 01). EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. J Bone Miner Res. 26, 792-802.
• 1. Reynolds DG
  2. Takahata M
  3. Lerner AL
  4. O'Keefe RJ
  5. Schwarz EM
  6. Awad HA
  (2011 Mar 01). Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model. Bone. 48, 562-70.
• 1. Jacobson JA
  2. Yanoso-Scholl L
  3. Reynolds DG
  4. Dadali T
  5. Bradica G
  6. Bukata S
  7. Puzas EJ
  8. Zuscik MJ
  9. Rosier R
  10. O'Keefe RJ
  11. Schwarz EM
  12. Awad HA
  (2011 Feb 01). Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue Eng Part A. 17, 389-98.
• 1. Li J
  2. Zhou Q
  3. Wood RW
  4. Kuzin I
  5. Bottaro A
  6. Ritchlin CT
  7. Xing L
  8. Schwarz EM
  (2011 Jan 01). CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice. Arthritis Res Ther. 13, R138.
• 1. Bukata SV
  2. Digiovanni BF
  3. Friedman SM
  4. Hoyen H
  5. Kates A
  6. Kates SL
  7. Mears SC
  8. Mendelson DA
  9. Serna FH
  10. Sieber FE
  11. Tyler WK
  (2011 Jan 01). A guide to improving the care of patients with fragility fractures. Geriatr Orthop Surg Rehabil. 2, 5-37.
• 1. Yanoso-Scholl L
  2. Jacobson JA
  3. Bradica G
  4. Lerner AL
  5. O'Keefe RJ
  6. Schwarz EM
  7. Zuscik MJ
  8. Awad HA
  (2010 Dec 01). Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. J Biomed Mater Res A. 95, 717-26.
• 1. Papuga MO
  2. Proulx ST
  3. Kwok E
  4. You Z
  5. Rubery PT
  6. Dougherty PE
  7. Hilton MJ
  8. Awad HA
  9. Schwarz EM
  (2010 Sep 01). Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. J Orthop Res. 28, 1220-8.
• 1. Li TF
  2. Gao L
  3. Sheu TJ
  4. Sampson ER
  5. Flick LM
  6. Konttinen YT
  7. Chen D
  8. Schwarz EM
  9. Zuscik MJ
  10. Jonason JH
  11. O'Keefe RJ
  (2010 Aug 01). Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. Arthritis Rheum. 62, 2359-69.
• 1. Gunnell LM
  2. Jonason JH
  3. Loiselle AE
  4. Kohn A
  5. Schwarz EM
  6. Hilton MJ
  7. O'Keefe RJ
  (2010 Aug 01). TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res. 25, 1784-97.
• 1. Li J
  2. Kuzin I
  3. Moshkani S
  4. Proulx ST
  5. Xing L
  6. Skrombolas D
  7. Dunn R
  8. Sanz I
  9. Schwarz EM
  10. Bottaro A
  (2010 Jun 01). Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy. J Immunol. 184, 6142-50.
• 1. Mensah KA
  2. Mathian A
  3. Ma L
  4. Xing L
  5. Ritchlin CT
  6. Schwarz EM
  (2010 Apr 01). Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis. Arthritis Rheum. 62, 1127-37.
• 1. Mensah KA
  2. Ritchlin CT
  3. Schwarz EM
  (2010 Apr 01). RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens. J Cell Physiol. 223, 76-83.
• 1. Li D
  2. Gromov K
  3. Proulx ST
  4. Xie C
  5. Li J
  6. Crane DP
  7. Søballe K
  8. O'Keefe RJ
  9. Awad HA
  10. Xing L
  11. Schwarz EM
  (2010 Mar 01). Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Ann N Y Acad Sci. 1192, 84-94.
• 1. Chiu YG
  2. Shao T
  3. Feng C
  4. Mensah KA
  5. Thullen M
  6. Schwarz EM
  7. Ritchlin CT
  (2010 Jan 01). CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis. Arthritis Res Ther. 12, R14.
• 1. Schwarz EM
  2. Proulx ST
  3. Ritchlin CT
  4. Boyce BF
  5. Xing L
  (2010 Jan 01). The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis. Adv Exp Med Biol. 658, 1-10.
• 1. Mensah KA
  2. Li J
  3. Schwarz EM
  (2009 Dec 01). The emerging field of osteoimmunology. Immunol Res. 45, 100-13.
• 1. Tyler WK
  2. Healey JH
  3. Morris CD
  4. Boland PJ
  5. O'Donnell RJ
  (2009 Nov 01). Compress periprosthetic fractures: interface stability and ease of revision. Clin Orthop Relat Res. 467, 2800-6.
• 1. Darowish M
  2. Rahman R
  3. Li P
  4. Bukata SV
  5. Gelinas J
  6. Huang W
  7. Flick LM
  8. Schwarz EM
  9. O'Keefe RJ
  (2009 Oct 01). Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation. Bone. 45, 661-8.
• 1. Tsutsumi R
  2. Xie C
  3. Wei X
  4. Zhang M
  5. Zhang X
  6. Flick LM
  7. Schwarz EM
  8. O'Keefe RJ
  (2009 Oct 01). PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis. J Bone Miner Res. 24, 1753-62.
• 1. Guo R
  2. Zhou Q
  3. Proulx ST
  4. Wood R
  5. Ji RC
  6. Ritchlin CT
  7. Pytowski B
  8. Zhu Z
  9. Wang YJ
  10. Schwarz EM
  11. Xing L
  (2009 Sep 01). Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis. Arthritis Rheum. 60, 2666-76.
• 1. Xie C
  2. Liang B
  3. Xue M
  4. Lin AS
  5. Loiselle A
  6. Schwarz EM
  7. Guldberg RE
  8. O'Keefe RJ
  9. Zhang X
  (2009 Aug 01). Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4. Am J Pathol. 175, 772-85.
• 1. Crane DP
  2. Gromov K
  3. Li D
  4. Søballe K
  5. Wahnes C
  6. Büchner H
  7. Hilton MJ
  8. O'Keefe RJ
  9. Murray CK
  10. Schwarz EM
  (2009 Aug 01). Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis. J Orthop Res. 27, 1008-15.
• 1. Loiselle AE
  2. Bragdon GA
  3. Jacobson JA
  4. Hasslund S
  5. Cortes ZE
  6. Schwarz EM
  7. Mitten DJ
  8. Awad HA
  9. O'Keefe RJ
  (2009 Jun 01). Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. J Orthop Res. 27, 833-40.
• 1. Reynolds DG
  2. Shaikh S
  3. Papuga MO
  4. Lerner AL
  5. O'Keefe RJ
  6. Schwarz EM
  7. Awad HA
  (2009 May 01). muCT-based measurement of cortical bone graft-to-host union. J Bone Miner Res. 24, 899-907.