Yeast Molecular Biology & Genetics
The Sherman Lab has been investigating various broad aspects of gene expression in yeast, as means to determine processes operating in eukaryotic cells. By using iso-1-cytochrome c as a model system, general principles have been uncovered, including those involved in transcription, translation, co-translational and post-translational modification, mitochondrial import, heme attachment, enzymatic functions and protein degradation. Currently, efforts have been directed toward understanding the relationships between protein structure, protein modifications and degradation in vivo, and in uncovering new degradation systems in mitochondria.
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 109, 12449-54. (2012 Jul 31).
- N(α)-Acetylation of yeast ribosomal proteins and its effect on protein synthesis. J Proteomics. 74, 431-41. (2011 Apr 01).
- Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding. J Amino Acids. 2011, 843206. (2011 Jan 01).