Welcome to the Takimoto Lab
The main focus of our research is to reveal molecular mechanism of parainfluenza and influenza virus infection, replication, and assembly and host-virus interactions. We analyze structures and functions of viral proteins as well as interactions between viral and cellular proteins to reveal the mechanism of virus growth and to identify the factors that restrict host range of the viruses. Our study will unveil the process of viral replication and assembly, which are essential for developing antiviral agents.
Current Research Projects
- Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures.J Virol. 89, 8042-9. (2015 Aug 01).
- Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses.J Virol. 89, 6442-52. (2015 Jun 01).
- Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.FEBS Lett. 589, 1278-82. (2015 May 08).