Principal Investigator

Toru Takimoto, D.V.M., Ph.D. University of Rochester work Box 672 601 Elmwood Ave Rochester NY 14642 p (585) 273-2856 f (585) 273-9573

Research Projects

  • Functional analysis of influenza virus PA-X in host shutoff

    Functional analysis of influenza virus PA-X in host shutoff

    Influenza virus infection causes global inhibition of host protein synthesis in infected cells. This host shutoff is thought to allow viruses to escape from the host antiviral response, which restricts virus replication and spread. Although the mechanism of host shutoff is unclear, a novel viral protein expressed by ribosomal frameshifting, PA-X, was found to play a major role in influenza virus-induced host shutoff. More info...

  • Molecular Mechanism of Paramyxovirus Assembly

    Molecular Mechanism of Paramyxovirus Assembly

    Sendai virus (SeV) is a pneumotropic murine pathogen in the Paramyxoviridae family, which includes many clinically important human pathogens. It is an enveloped negative-strand RNA virus and encodes 6 major structural proteins: two glycoproteins (HN and F), the matrix (M) protein, the nucleoprotein (NP), and the phosphoprotein (P) and large (L) proteins, which make up the polymerase complex. More info...

  • Role of Influenza Polymerase in Host Adaptation

    Role of Influenza Polymerase in Host Adaptation

    Influenza A viruses are negative-sense, single-stranded, segmented RNA viruses that infect a wide range of hosts, including humans and many avian species. One mechanism for the instigation of a pandemic is direct infection of humans with an avian virus that contains mutations allowing it to easily infect and spread among humans. More info...