David
Topham, Ph.D.
University of Rochester
work
Box 609
601 Elmwood Ave
Rochester
NY
14642
office: KMRB 3-9631
p
585-273-1403
f
585-273-2452
David_Topham@urmc.rochester.edu
Innate immunity to influenza
Recently, the lab has begun investigating the role of Natural Killer (NK) cells in primary and secondary influenza infections. Contrary to present dogma, we find that NK cells are a major part of the cellular immune response throughout the acute phase of primary infection, not just the first few days, and are more rapidly invoked by secondary infection. In addition to antiviral functions, the NK cells critically participate in repair of the lung epithelium to maintain barrier function.
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