Principal Investigator

David Topham, Ph.D. University of Rochester work Box 609 601 Elmwood Ave Rochester NY 14642 office: KMRB 3-9631 p 585-273-1403 f 585-273-2452

Innate immunity to influenza

Natural Killer Cell response to influenza

Recently, the lab has begun investigating the role of Natural Killer (NK) cells in primary and secondary influenza infections. Contrary to present dogma, we find that NK cells are a major part of the cellular immune response throughout the acute phase of primary infection, not just the first few days, and are more rapidly invoked by secondary infection. In addition to antiviral functions, the NK cells critically participate in repair of the lung epithelium to maintain barrier function.

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